[The heparin prophylaxis of gas exchange disorders in disseminated intravascular blood coagulation]. / Geparinprofilaktika narushenii gazoobmena pri disseminirovannom vnutrisosudistom svertyvanii krovi.

Altogether 35 patients operated on for gastric carcinoma were examined. In the postoperative period, a study was made of alterations in gas exchange function of the lungs parallel with the parameters of the hemostatic system. It has been established that in the early postoperative period, arterial hypoxemia was associated with the maximum tension of the functioning of the hemocoagulation system. Administration of heparin in a dose of 20,000 Units/day for 10 days led to a decrease of the period of arterial hypoxemia and reduction of its intensity. This is related to the blockade of intravascular blood coagulation. The heparin dose administered does not influence the plasma content of antithrombin-III and blood fibrinolytic activity.

[The products of blood coagulation and fibrinolysis and their effect on pulmonary gas-exchange function]. / Produkty gemokoaguliatsii i fibrinoliza i ikh vliianie na gazoobmennuiu funktsiiu legkikh.

The authors' and reported data have demonstrated the effect of hemocoagulation and fibrinolysis products on gas exchange pulmonary function in patients who suffered surgical intervention. The results of examining 20 patients with gastric carcinoma are provided. It has been established that even before operation the patients manifested the chronic pattern of the disseminated intravascular coagulation (DIC) syndrome, whose intensity increased in the postoperative period. The rise in the blood of soluble complexes of fibrin monomer (SCFM) and fibrin degradation products (FDP) formed during intravascular coagulation was established to play an important role in the impairment of gas exchange pulmonary function in the postoperative period in patients with the chronic pattern of the DIC syndrome. A possible mechanism by which SCFM and FDP influence pulmonary gas exchange is reviewed.

[Functional reserves of blood circulation in aged patients]. / Funktsional'nye rezervy krovoobrashcheniia u pozhilykh bol'nykh.

Central hemodynamics (CH) were studied in 43 elderly (72.4 years) patients by means of the Swan-Ganz catheter. Analysis according to three main criteria--the clinical picture and the values of volume blood flow and jamming pressure in the pulmonary artery--disclosed several hemodynamic types. The "hypovolemic" CH variant was prevalent (17), the eukinetic type of CH was encountered in 8, the "hyperkinetic" type--in 7, and the "hypokinetic" type--in 2 patients. Some parameters of the system of oxygen transport were used as additional information. Patients with limited reserves of circulation were set apart. Additional preoperative management for correcting CH disorders was recommended for them. It is concluded that the approach to the appraisal of the condition and reserves of circulation in the elderly must be more scrupulous.