ABSTRACT
We compared a multiplex polymerase chain reaction assay and a shell vial assay for the detection of herpesviruses infection in 13 Cuban patients who had received kidney transplants. Cytomegalovirus and human herpesvirus 6 were detected in these patients.
Subject(s)
Herpesviridae Infections/virology , Herpesviridae , Kidney Transplantation/adverse effects , Postoperative Complications/virology , Adult , Cuba , Female , Humans , Longitudinal Studies , MaleABSTRACT
Infections from herpes virus play a key role in post-transplantation pathology, so it is indispensable to characterize the group of would-be renal transplant recipients. IgG antibody titers were detected by indirect immunofluorescence to Herpes simplex virus, Epstein Barr virus (EBV) and cytomegalovirus (CMV) in 100 patients treated with hemodialysis in the Nephrology Institute. The prevalence of antibodies to cytomegalovirus and to Herpes simplex and Epstein Barr viruses was 100 and 95 respectively. Average geometric titers (AGT) of antibodies to CMV were significantly higher. There was no correlation between AGT and sex, age, time of disease remission, number of blood transfusions and number of transplants.
Subject(s)
Humans , Male , Female , Adult , Antibodies, Viral , Cytomegalovirus , Herpesvirus 4, Human , Renal Dialysis , Simplexvirus , PrevalenceABSTRACT
Las infecciones producidas por herpesvirus desempeñan un papel fundamental en la patología postrasplante lo que hace imprescindible tener caracterizada desde el punto de vista serológico a la población candidata de recibir un injerto renal. Se detectaron títulos de anticuerpos IgG mediante inmunofluorescencia indirecta contra virus herpes simple (VHS), virus Epstein Barr (VEB) y citomegalovirus (CMV), en 100 pacientes sometidos a tratamiento hemodialítico en el Instituto de Nefrología. Se detectó una prevalencia de anticuerpos de 100 por ciento para el CMV y de 95 por ciento para el VHS y el VEB. Los títulos promedios geométricos (TPG) de anticuerpos contra CMV resultaron ser significativamente superiores. No se encontró correlación entre los TPG y el sexo, la edad, el tiempo de evolución de la enfermedad, el número de transfusiones y el número de trasplantes(AU)
