ABSTRACT
Crude extracts of Haplopappus sonorensis (A. Gray) S.F. Blake (Asteraceae), showed activity against Mycobacterium tuberculosis H(37)Rv. By assay-guided fractionation, 5-hydroxy-3,7,4'-trimethoxyflavone (1). 5,7-dihydroxy-3,4'-dimethoxyflavone (2). and 5,4'-dihydroxy-3,7-dimethoxyflavone (3). were identified as the antimycobacterial principles. Compound 2 was the most active compound.
Subject(s)
Antitubercular Agents/pharmacology , Flavonoids/pharmacology , Haplopappus , Mycobacterium tuberculosis/drug effects , Phytotherapy , Plant Extracts/pharmacology , Humans , Microbial Sensitivity Tests , Tumor Cells, Cultured/drug effectsABSTRACT
The minimum inhibitory concentrations (MIC) of carnosol and of the ethanolic extract from the aerial part of Lepechinia hastata were determined against Streptococcus pyogenes, Bacillus subtilis, Staphylococcus aureus, S. epidermidis, S. aureus (2), S. aureus "A", and S. aureus "B", (strains "A" and "B" are resistant to penicillin and ampicillin), Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, Salmonella typhimurium, Proteus vulgaris, and Pseudomonas aeruginosa and Candida albicans. Carnosol and the ethanol extract showed activity against gram (+) bacteria, but no activity against the yeast and the gram (-) bacteria.
ABSTRACT
The ethanolic extracts of 72 plants belonging to 35 different families, and used in traditional medicine in Baja California Sur (México), were tested for antimicrobial activity in vitro using the filter paper disk assay method. Activity against Staphylococcus aureus, Bacillus subtilis, Streptococcus faecalis (Gram-positive microorganisms), Escherichia coli (Gram-negative microorganisms) and Candida albicans (yeast) is discussed.
Subject(s)
Anti-Bacterial Agents , Plants, Medicinal , Anti-Bacterial Agents/isolation & purification , Medicine, Traditional , Mexico , Microbial Sensitivity Tests , Plant Extracts/pharmacologyABSTRACT
Continuing our studies of traditional medicine, as used in rural areas of Baja California Sur, now we wish to report on the medicinal uses of 49 more plants. Some of the more complex recipes of these medicinal plants, are discussed in the present paper. The information presented here was collected in the Municipio of Los Cabos and part of the Municipio of La Paz, B.C.S., Mexico.
