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1.
Curr Pediatr Rep ; 9(3): 77-82, 2021.
Article in English | MEDLINE | ID: mdl-34258106

ABSTRACT

Purpose of Review: To highlight some achievements made through usage of telecommunication technologies in Mongolia as an example of a developing country with remote areas. Recent Findings: Telemedicine can be implemented not only for remote monitoring, diagnosing, and treating purposes but also can be effectively used for delivering knowledge and consultation services via modern technologies. Summary: Tele-health services can be successfully added to the traditional approach of physicians, especially in the countries with a vast territory with distant areas.

2.
EBioMedicine ; 39: 510-519, 2019 Jan.
Article in English | MEDLINE | ID: mdl-30552064

ABSTRACT

BACKGROUND: In winter in Mongolia, 80% of adults have 25-hydroxyvitamin D (25(OH)D) concentrations <25 nmol/l (<10 ng/ml) and 99% have <50 nmol/l (<20 ng/ml). The vitamin D dose to avert deficiency during pregnancy in this population is unknown. METHODS: We conducted a randomized, controlled, double-blind trial of daily 600, 2000, or 4000 IU vitamin D3 for pregnant women in Mongolia (Clinicaltrials.gov #NCT02395081). We examined 25(OH)D concentrations at baseline (12-16 weeks' gestation), 36-40 weeks' gestation and in umbilical cord blood, using enzyme linked fluorescent assay. Sample size was determined to detect 0.4 standard deviation differences in 25(OH)D concentrations with 80% power. FINDINGS: 119 pregnant women were assigned 600 IU, 121 assigned 2000 IU and 120 assigned 4000 IU from February 2015 through December 2016. Eighty-eight percent of participants took ≥80% of assigned supplements. At baseline, 25(OH)D concentrations were similar across arms; overall mean ±â€¯standard deviation concentration was 19 ±â€¯22 nmol/l; 91% were < 50 nmol/l. At 36-40 weeks, 25(OH)D concentrations increased to 46 ±â€¯21, 70 ±â€¯23, and 81 ±â€¯29 nmol/l for women assigned 600, 2000, and 4000 IU, respectively (p < 0.0001 across arms; p = 0.002 for 2000 vs. 4000 IU). Mean umbilical cord 25(OH)D concentrations differed by study arm (p < 0.0001 across arms; p < 0.0001 for 2000 vs. 4000 IU) and were proportional to maternal concentrations. There were no adverse events, including hypercalcemia, attributable to vitamin D supplementation. INTERPRETATION: Daily supplementation of 4000 IU during pregnancy is safe and achieved higher maternal and neonatal 25(OH)D concentrations than 2000 IU. Daily 600 IU supplements are insufficient to prevent vitamin D deficiency in Mongolia. FUND: Anonymous foundation and Brigham and Women's Hospital.


Subject(s)
Fetal Blood/chemistry , Pregnancy Trimesters/blood , Vitamin D Deficiency/drug therapy , Vitamin D/analogs & derivatives , Adult , Dietary Supplements , Dose-Response Relationship, Drug , Double-Blind Method , Female , Humans , Pregnancy , Pregnancy Trimester, First/blood , Pregnancy Trimester, Third/blood , Treatment Outcome , Vitamin D/administration & dosage , Vitamin D/therapeutic use , Young Adult
3.
Article in English | WPRIM (Western Pacific) | ID: wpr-631211

ABSTRACT

Acute lung injury and acute respiratory distress syndrome among children are clinical entities of multifactorial origin requiring intensive care. Pediatric acute respiratory distress syndrome is a devastating lung condition with high mortality being the end result of a wide variety of inciting events. The purpose of this article is to review recent evidence for the epidemiology, clinical signs, diagnosis and treatment of the acute respiratory distress syndrome in chidlren.

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