Night time heart rate predicts next-day pain in fibromyalgia and primary back pain.

Introduction: Primary chronic pain is pain that persists for over 3 months without associated measurable tissue damage. One of the most consistent findings in primary chronic pain is its association with autonomic hyperactivation. Yet whether the autonomic hyperactivation causes the pain or results from it is still unclear. It is also unclear to what extent autonomic hyperactivation is related to experienced pain intensity in different subtypes or primary chronic pain. Objectives: Our first aim was to test lagged relationships between the markers of autonomic activation (heart rate) and pain intensity to determine its directionality. The main question here was whether autonomic biomarkers predict pain intensity or whether pain intensity predicts autonomic biomarkers. The second aim was to test whether this relationship is different between people with primary back pain and people with fibromyalgia. Methods: Sixty-six patients with chronic pain were observed over an average of 81 days. Sleep heart rate and heart rate variability were measured with a wearable sensor, and pain intensity was assessed from daily subjective reports. Results: The results showed a predictive relationship between sleep heart rate and next-day pain intensity (P < 0.05), but not between daily pain intensity and next night heart rate. There was no interaction with the type of chronic pain. Conclusions: These findings suggest that autonomic hyperactivation, whether stress-driven or arising from other causes, precedes increases in primary chronic pain. Moreover, the present results suggest that autonomic hyperactivation is a common mechanism underlying the pain experience in fibromyalgia and chronic back pain.

A Fusion Algorithm Based on a Constant Velocity Model for Improving the Measurement of Saccade Parameters with Electrooculography.

Electrooculography (EOG) serves as a widely employed technique for tracking saccadic eye movements in a diverse array of applications. These encompass the identification of various medical conditions and the development of interfaces facilitating human-computer interaction. Nonetheless, EOG signals are often met with skepticism due to the presence of multiple sources of noise interference. These sources include electroencephalography, electromyography linked to facial and extraocular muscle activity, electrical noise, signal artifacts, skin-electrode drifts, impedance fluctuations over time, and a host of associated challenges. Traditional methods of addressing these issues, such as bandpass filtering, have been frequently utilized to overcome these challenges but have the associated drawback of altering the inherent characteristics of EOG signals, encompassing their shape, magnitude, peak velocity, and duration, all of which are pivotal parameters in research studies. In prior work, several model-based adaptive denoising strategies have been introduced, incorporating mechanical and electrical model-based state estimators. However, these approaches are really complex and rely on brain and neural control models that have difficulty processing EOG signals in real time. In this present investigation, we introduce a real-time denoising method grounded in a constant velocity model, adopting a physics-based model-oriented approach. This approach is underpinned by the assumption that there exists a consistent rate of change in the cornea-retinal potential during saccadic movements. Empirical findings reveal that this approach remarkably preserves EOG saccade signals, resulting in a substantial enhancement of up to 29% in signal preservation during the denoising process when compared to alternative techniques, such as bandpass filters, constant acceleration models, and model-based fusion methods.

Listening to trees in the forest: Attentional set influences how semantic and acoustic factors interact in auditory perception.

Studies of auditory object perception claim that semantic properties dominate acoustic properties in determining identification accuracy. Yet the direction of the semantic effect is mixed, with some studies showing an advantage for detecting incongruent sounds and others reporting a congruent sound advantage. Here we examine the role of the participant's attentional set when identifying auditory objects in naturalistic soundscapes. We varied the acoustic and semantic properties of the sounds orthogonally in two experiments. In Experiment 1 participants tuned their attention broadly to detect any change between two successive soundscapes (e.g., two restaurant soundscapes, with and without a child coughing). In Experiment 2 they tuned attention more narrowly to a probe presented after a soundscape (e.g., a restaurant soundscape with a child coughing, followed by the coughing sound alone). In both experiments, semantic relations between the objects and backgrounds helped to disambiguate objects that blended acoustically with the background. When attending globally (Experiment 1), objects that were acoustically similar yet semantically incongruent tended to be missed (e.g., bouncing basketball on a construction site), as though camouflaged by the gist of the soundscape. When attending locally (Experiment 2), semantically congruent foil objects led to false positive reports under acoustically similar conditions (hammering sounds on a construction site), as though the gist of the soundscape contributed to their plausible inclusion. In summary, although attentional set had a strong influence on the specific kinds of errors made, both results pointed to participants using a semantically congruent high-level schema to report the sounds they heard.

On the Reliability of Wearable Technology: A Tutorial on Measuring Heart Rate and Heart Rate Variability in the Wild.

Wearable sensors are quickly making their way into psychophysiological research, as they allow collecting data outside of a laboratory and for an extended period of time. The present tutorial considers fidelity of physiological measurement with wearable sensors, focusing on reliability. We elaborate on why ensuring reliability for wearables is important and offer statistical tools for assessing wearable reliability for between participants and within-participant designs. The framework offered here is illustrated using several brands of commercially available heart rate sensors. Measurement reliability varied across sensors and, more importantly, across the situations tested, and was highest during sleep. Our hope is that by systematically quantifying measurement reliability, researchers will be able to make informed choices about specific wearable devices and measurement procedures that meet their research goals.

The Attractiveness of Masked Faces Is Influenced by Race and Mask Attitudes.

This study tests the influence of wearing a protective face mask on the perceived attractiveness of the wearer. Participants who identified as White, and who varied in their ideological stance toward mask wearing, rated the attractiveness of facial photographs. The photos varied in baseline attractiveness (low, medium, and high), race (White and Asian), and whether or not the face was wearing a protective mask. Attitudes regarding protective masks were measured after the rating task using a survey to identify participants as either pro- or anti-mask. The results showed that masked individuals of the same race were generally rated as more attractive than unmasked individuals, but that masked individuals of another race were rated as less attractive than unmasked individuals. Moreover, pro-mask participants rated masked individuals as generally more attractive than unmasked individuals, whereas anti-maskers rated masked individuals as less attractive. A control experiment, replicating the procedure but replacing the protective masks with a partially occluding notebook, showed that these effects were mask-specific. These results demonstrate that perceived attractiveness is affected by characteristics of the viewer (attitudes toward protective masks), their relationship to the target (same or different race), and by circumstances external to both (pandemic).

In the hands of the beholder: Wearing a COVID-19 mask is associated with its attractiveness.

Protective facial masks reduce the spread of COVID-19 infection and save lives. Yet a substantial number of people have been resistant to wearing them. Considerable effort has been invested in convincing people to put on a mask, if not for their own sake than for those more vulnerable. Social and cognitive psychologists know that use and liking go both ways: people use what they like, and they like what they use. Here we asked whether positive attitudes towards facial masks were higher in those who had been wearing them longer. We asked participants in a diverse sample (N = 498 from five countries and more than 30 US states) to rate how attractive and emotionally arousing masks and other objects associated with COVID-19 were in comparison to neutral objects, as well as reporting on their mask-wearing habits. To confirm reliability of findings, the experiment was repeated in a subset of participants 8-10 weeks later. The findings show that regular use of protective masks was linked to their positive appraisal, with a higher frequency and a longer history of wearing a mask predicting increased mask attractiveness. These results extended to other COVID-related objects relative to controls. They also provide critical ecological validity for the idea that emotional appraisal of everyday objects is associated with our experience of using them. Practically, they imply that societal measures to encourage mask wearing may have contributed to positive emotional appraisals in those who put them on, whether due to personal choice or societal pressure.

The Ties that Bind: Agnosia, Neglect and Selective Attention to Visual Scale.

PURPOSE OF REVIEW: Historical and contemporary treatments of visual agnosia and neglect regard these disorders as largely unrelated. It is thought that damage to different neural processes leads directly to one or the other condition, yet apperceptive variants of agnosia and object-centered variants of neglect share remarkably similar deficits in the quality of conscious experience. Here we argue for a closer association between "apperceptive" variants of visual agnosia and "object-centered" variants of visual neglect. We introduce a theoretical framework for understanding these conditions based on "scale attention", which refers to selecting boundary and surface information at different levels of the structural hierarchy in the visual array. RECENT FINDINGS: We review work on visual agnosia, the cortical structures and cortico-cortical pathways that underlie visual perception, visuospatial neglect and object-centered neglect, and attention to scale. We highlight direct and indirect pathways involved in these disorders and in attention to scale. The direct pathway involves the posterior vertical segments of the superior longitudinal fasciculus that are positioned to link the established dorsal and ventral attentional centers in the parietal cortex with structures in the inferior occipitotemporal cortex associated with visual apperceptive agnosia. The connections in the right hemisphere appear to be more important for visual conscious experience, whereas those in the left hemisphere appear to be more strongly associated with the planning and execution of visually guided grasps directed at multi-part objects such as tools. In the latter case, semantic and functional information must drive the selection of the appropriate hand posture and grasp points on the object. This view is supported by studies of grasping in patients with agnosia and in patients with neglect that show that the selection of grasp points when picking up a tool involves both scale attention and semantic contributions from inferotemporal cortex. The indirect pathways, which include the inferior fronto-occipital and horizontal components of the superior longitudinal fasciculi, involve the frontal lobe, working memory and the "multiple demands" network, which can shape the content of visual awareness through the maintenance of goal- and task-based abstractions and their influence on scale attention. Recent studies of human cortico-cortical pathways necessitate revisions to long-standing theoretical views on visual perception, visually guided action and their integrations. We highlight findings from a broad sample of seemingly disparate areas of research to support the proposal that attention to scale is necessary for typical conscious visual experience and for goal-directed actions that depend on functional and semantic information. Furthermore, we suggest that vertical pathways between the parietal and occipitotemporal cortex, along with indirect pathways that involve the premotor and prefrontal cortex, facilitate the operations of scale attention.

The Comprehensive Autistic Trait Inventory (CATI): development and validation of a new measure of autistic traits in the general population.

BACKGROUND: Traits and characteristics qualitatively similar to those seen in diagnosed autism spectrum disorder can be found to varying degrees in the general population. To measure these traits and facilitate their use in autism research, several questionnaires have been developed that provide broad measures of autistic traits [e.g. Autism-Spectrum Quotient (AQ), Broad Autism Phenotype Questionnaire (BAPQ)]. However, since their development, our understanding of autism has grown considerably, and it is arguable that existing measures do not provide an ideal representation of the trait dimensions currently associated with autism. Our aim was to create a new measure of autistic traits that reflects our current understanding of autism, the Comprehensive Autism Trait Inventory (CATI). METHODS: In Study 1, 107 pilot items were administered to 1119 individuals in the general population and exploratory factor analysis of responses used to create the 42-item CATI comprising six subscales: Social Interactions, Communication, Social Camouflage, Repetitive Behaviours, Cognitive Rigidity, and Sensory Sensitivity. In Study 2, the CATI was administered to 1068 new individuals and confirmatory factor analysis used to verify the factor structure. The AQ and BAPQ were administered to validate the CATI, and additional autistic participants were recruited to compare the predictive ability of the measures. In Study 3, to validate the CATI subscales, the CATI was administered to 195 new individuals along with existing valid measures qualitatively similar to each CATI subscale. RESULTS: The CATI showed convergent validity at both the total-scale (r ≥ .79) and subscale level (r ≥ .68). The CATI also showed superior internal reliability for total-scale scores (α = .95) relative to the AQ (α = .90) and BAPQ (α = .94), consistently high reliability for subscales (α > .81), greater predictive ability for classifying autism (Youden's Index = .62 vs .56-.59), and demonstrated measurement invariance for sex. LIMITATIONS: Analyses of predictive ability for classifying autism depended upon self-reported diagnosis or identification of autism. The autistic sample was not large enough to test measurement invariance of autism diagnosis. CONCLUSIONS: The CATI is a reliable and economical new measure that provides observations across a wide range of trait dimensions associated with autism, potentially precluding the need to administer multiple measures, and to our knowledge, the CATI is also the first broad measure of autistic traits to have dedicated subscales for social camouflage and sensory sensitivity.

Action coordination during a real-world task: Evidence from children with and without autism spectrum disorder.

"Joint action"-the ability to coordinate actions with others-is critical for achieving individual and interpersonal goals and for our collective success as a species. Joint actions require accurate and rapid inferences about others' goals, intentions, and focus of attention, skills that are thought to be impaired in individuals with autism spectrum disorder (ASD). Research to date has not investigated joint action abilities in individuals with ASD during real-world social interactions. We conducted an experimental study that required children with ASD and typically developing children to move tables by themselves or collaboratively through a maze. This involved developing innovative methodologies for measuring action coordination-a critical component of the joint action process. We found that children with ASD are less likely to benefit from the collaboration of a peer than are typically developing children, and they are less likely to synchronize their steps when moving the table. However, these differences were masked when scaffolded by an adult. There was no evidence that ASD differences were due to gross motor delays in the participants with ASD. We argue that action coordination is a highly adaptive social process that is intrinsic to successful human functioning that manifests as atypical synchronization of mind and body in children with ASD.

Selective attention to real-world objects drives their emotional appraisal.

Attentional manipulations have been shown to influence subsequent evaluations of objects and images. For example, images used as distractors in a visual search task are subsequently rated more negatively than are target images. One powerful manipulation of attention occurs when we plan and execute movements toward objects in our environment. Here, in two experiments, we show that selective attention to real-world objects subsequently improves emotional appraisal of those objects-an effect we term "target appreciation." Participants were presented with abstract images on three-dimensional objects, and were cued to either reach and grasp one of the two objects, or to respond to the cued object with a keyboard. Images presented on target objects were appraised more positively when compared with novel images. In contrast, images associated with obstacles or distractor objects were not appraised differently than novel images, despite the attentional suppression thought to be required to successfully avoid or ignore these objects. We speculate that this automatic appreciation of the objects of selective attention may be adaptive for organisms acting in complex environments.

Reduced perceptual narrowing in synesthesia.

Synesthesia is a neurologic trait in which specific inducers, such as sounds, automatically elicit additional idiosyncratic percepts, such as color (thus "colored hearing"). One explanation for this trait-and the one tested here-is that synesthesia results from unusually weak pruning of cortical synaptic hyperconnectivity during early perceptual development. We tested the prediction from this hypothesis that synesthetes would be superior at making discriminations from nonnative categories that are normally weakened by experience-dependent pruning during a critical period early in development-namely, discrimination among nonnative phonemes (Hindi retroflex /d̪a/ and dental /ɖa/), among chimpanzee faces, and among inverted human faces. Like the superiority of 6-mo-old infants over older infants, the synesthetic groups were significantly better than control groups at making all the nonnative discriminations across five samples and three testing sites. The consistent superiority of the synesthetic groups in making discriminations that are normally eliminated during infancy suggests that residual cortical connectivity in synesthesia supports changes in perception that extend beyond the specific synesthetic percepts, consistent with the incomplete pruning hypothesis.

Neural dynamics of the attentional blink revealed by encoding orientation selectivity during rapid visual presentation.

The human brain is inherently limited in the information it can make consciously accessible. When people monitor a rapid stream of visual items for two targets, they typically fail to see the second target if it occurs within 200-500 ms of the first, a phenomenon called the attentional blink (AB). The neural basis for the AB is poorly understood, partly because conventional neuroimaging techniques cannot resolve visual events displayed close together in time. Here we introduce an approach that characterises the precise effect of the AB on behaviour and neural activity. We employ multivariate encoding analyses to extract feature-selective information carried by randomly-oriented gratings. We show that feature selectivity is enhanced for correctly reported targets and suppressed when the same items are missed, whereas irrelevant distractor items are unaffected. The findings suggest that the AB involves both short- and long-range neural interactions between visual representations competing for access to consciousness.

The Role of Haptic Expectations in Reaching to Grasp: From Pantomime to Natural Grasps and Back Again.

When we reach to pick up an object, our actions are effortlessly informed by the object's spatial information, the position of our limbs, stored knowledge of the object's material properties, and what we want to do with the object. A substantial body of evidence suggests that grasps are under the control of "automatic, unconscious" sensorimotor modules housed in the "dorsal stream" of the posterior parietal cortex. Visual online feedback has a strong effect on the hand's in-flight grasp aperture. Previous work of ours exploited this effect to show that grasps are refractory to cued expectations for visual feedback. Nonetheless, when we reach out to pretend to grasp an object (pantomime grasp), our actions are performed with greater cognitive effort and they engage structures outside of the dorsal stream, including the ventral stream. Here we ask whether our previous finding would extend to cued expectations for haptic feedback. Our method involved a mirror apparatus that allowed participants to see a "virtual" target cylinder as a reflection in the mirror at the start of all trials. On "haptic feedback" trials, participants reached behind the mirror to grasp a size-matched cylinder, spatially coincident with the virtual one. On "no-haptic feedback" trials, participants reached behind the mirror and grasped into "thin air" because no cylinder was present. To manipulate haptic expectation, we organized the haptic conditions into blocked, alternating, and randomized schedules with and without verbal cues about the availability of haptic feedback. Replicating earlier work, we found the strongest haptic effects with the blocked schedules and the weakest effects in the randomized uncued schedule. Crucially, the haptic effects in the cued randomized schedule was intermediate. An analysis of the influence of the upcoming and immediately preceding haptic feedback condition in the cued and uncued random schedules showed that cuing the upcoming haptic condition shifted the haptic influence on grip aperture from the immediately preceding trial to the upcoming trial. These findings indicate that, unlike cues to the availability of visual feedback, participants take advantage of cues to the availability of haptic feedback, flexibly engaging pantomime, and natural modes of grasping to optimize the movement.

Corrigendum: Positive Effects of Nature on Cognitive Performance Across Multiple Experiments: Test Order but Not Affect Modulates the Cognitive Effects.

[This corrects the article DOI: 10.3389/fpsyg.2019.01413.].

Positive Effects of Nature on Cognitive Performance Across Multiple Experiments: Test Order but Not Affect Modulates the Cognitive Effects.

Interactions with natural environments and nature-related stimuli have been found to be beneficial to cognitive performance, in particular on executive cognitive tasks with high demands on directed attention processes. However, results vary across different studies. The aim of the present paper was to evaluate the effects of nature vs. urban environments on cognitive performance across all of our published and new/unpublished studies testing the effects of different interactions with nature vs. urban/built control environments, on an executive-functioning test with high demands on directed attention-the backwards digit span (BDS) task. Specific aims in this study were to: (1) evaluate the effect of nature vs. urban environment interactions on BDS across different exposure types (e.g., real-world vs. artificial environments/stimuli); (2) disentangle the effects of testing order (i.e., effects caused by the order in which experimental conditions are administered) from the effects of the environment interactions, and (3) test the (mediating) role of affective changes on BDS performance. To this end, data from 13 experiments are presented, and pooled data-analyses are performed. Results from the pooled data-analyses (N = 528 participants) showed significant time-by-environment interactions with beneficial effects of nature compared to urban environments on BDS performance. There were also clear interactions with the order in which environment conditions were tested. Specifically, there were practice effects across environment conditions in first sessions. Importantly, after parceling out initial practice effects, the positive effects of nature compared to urban interactions on BDS performance were magnified. Changes in positive or negative affect did not mediate the beneficial effects of nature on BDS performance. These results are discussed in relation to the findings of other studies identified in the literature. Uncontrolled and confounding order effects (i.e., effects due to the order of experimental conditions, rather than the treatment conditions) may explain some of the inconsistent findings across studies in the literature on nature effects on cognitive performance. In all, these results highlight the robustness of the effects of natural environments on cognition, particularly when confounding order effects have been considered, and provide a more nuanced account of when a nature intervention will be most effective.

Superstitious Perception: Comparing Perceptual Prediction by Humans and Neural Networks.

Recent developments in convolutional neural networks (CNNs) have introduced new ways to model the complex processes of human vision. To date, the comparison of human vision and CNNs has focused on internal representations (i.e., receptive fields), with behavioral comparisons left largely unexplored. Here, we probe the influence of cognitive strategy on the similarity between CNN output and human behavior. We gave study participants a superstitious perception task (i.e., we asked them to detect an assigned target in white noise) while asking them to engage in either an active or passive attentional strategy. Previous research has shown that an active attentional strategy tends to engage central executive functions, whereas a passive strategy allows perceptual processes to unfold with limited central control. The results showed that the pattern of human responses in the superstitious perception task depended significantly on task strategy. Specifically, detecting targets superstitiously (i.e., false alarms) was correlated with evidence of a target's presence in the passive condition, but not in the active condition.Human data were compared to the performance of a CNN performing the same task, with the decision criterion of the CNN set to match the false alarm rates observed in the two strategy conditions of the human participants. CNN responses resembled those of human participants in the passive condition more closely than those in the active condition. This observation suggests that the CNN does a better job of mimicking human behavior when central executive functions are not engaged than when they are engaged. This, in turn, has important implications for what human participants are doing in the superstitious perception task. Namely, it implies that superstitious perception may have two important ingredients that are somewhat dissociable. First, there is the ability to detect weak signals in noise that correspond to the target image. This appears to be what participants are doing under passive strategy conditions; they allow externally generated signals to dominate their perceptual experience. Second, there is the ability to ignore the noise in favor of basing responses solely on internally generated signals. This seems to correspond more closely to what participants are doing under active strategy conditions, when attention is controlled by representations in memory. This research emphasizes the importance of modeling the full range of human responsiveness in even a simple noisy detection task.

Visuomotor adaptation in the absence of input from early visual cortex.

Prism adaptation is a time-honored tool for studying how the motor system adapts to sensory perturbations. Past research on the neural substrates of prism adaptation has implicated the posterior parietal cortex (PPC) and the cerebellum, under the assumption that these structures gain their visual input from the dominant retinogeniculate pathway to V1. Here we question whether this pathway is even required for visuomotor adaptation to occur. To investigate this, we examined prism adaptation in 'MC', someone who is blind to static stimuli following bilateral lesions that encompass much of her occipital cortex and the caudal-most areas of ventrotemporal cortex. Remarkably, MC shows evidence of prism adaptation that is similar to healthy control participants. First, when pointing with either the left or the right hand, MC shows spatial realignment; the classical after-effect exhibited by most people when adapting to displacing prisms. Second, MC demonstrates strategic recalibration - a reduction in her pointing error over time - that is similar in magnitude to healthy controls. These findings suggest that the geniculostriate pathway is not necessary for visuomotor adaptation to take place. Alternatively, we suggest that an extrageniculostriate pathway which provides visual inputs to the cerebellum from area MT and the PPC via the dorsolateral pons plays a significant and appreciable role in the guidance of unconscious automatic visuomotor adaptation.