[Cytologic diagnosis of recurrences of epithelial tumors of the bladder]. / Tsitologicheskaia diagnostika retsidivov épitelial'nykh opukholei mochevogo puzyria.

The cytologic method for urinalysis is available, inexpensive, and permits multiple examinations over the course of treatment. Cytologic analyses of the urine in 300 patients with bladder tumors have revealed relapses after the course of treatment in 30 cases, no clinical symptoms being detectable. A trefoil-shaped grouping of cells in cytologic preparations was found to be characteristic of transitional-cell papilloma and therefore fit to serve as a diagnostic sign. Cellular polymorphism is not so manifest in bladder carcinoma relapses, though the cells essentially differ from those of transitional-cell papilloma. Therefore, cytologic analysis of the urine is an effective method for the diagnosis of epithelial tumors of the bladder.

[The pathogenesis of disease and the significance of laboratory testing methods]. / Patogenez bolezni i znachenie laboratornykh metodov issledovaniia.

The general regularities in the development of a disease permit distinguishing the following stages in the pathogenesis: molecular, subcellular, cellular, organic, and body. The significance of the laboratory methods of investigation should be assessed with due consideration for the clinical course, other methods of investigation, and the pathogenesis stage. Only a close cooperation between the laboratory physician and the clinician may yield the wished for results in the diagnosis and treatment of various disease of man.

[Current aspects of cytologic diagnosis]. / Sovremennye aspekty tsitologicheskoi diagnostiki.

Cytologic investigations are among the most informative present-day diagnostic methods. Development of such investigations necessitates improvement of methods for the collection of biological material, studies on radiologic and drug pathomorphosis, on relapses and atypical forms of diseases. Effective realization of the potentialities of the cytologic method calls for close cooperation between the clinicians and cytologists.

[Stroma of epithelial bladder tumors]. / Stroma épitelial'nykh opukholei mochevogo puzyria.

The stroma of 509 epithelial tumors of the urinary bladder was examined. There was found a definite correlation between the stroma status, its histochemical properties and the histological structure of bladder tumor. During growth and malignant transformation the stroma and its histochemical pattern is significantly changed. The process of fibrosis develops with the accumulation of NMPS and decrease of AMPS as well as the reduction of argyrophil fibres characteristic of papilloma and differentiated transitional cell cancer. A predominance of argyrophil fibres with the accumulation of AMPS is typical for undifferentiated cancer which early infiltrates the organ wall and metastasize rapidly and extensively.