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Org Biomol Chem
; 11(22): 3706-32, 2013 Jun 14.
Article
in English
| MEDLINE
| ID: mdl-23624850
ABSTRACT
We herein report on the pharmacophore determination of the ERK docking domain inhibitor (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione, which has led to the discovery of compounds with greater selectivities for inhibiting the proliferation of melanoma cells containing active ERK signaling.