ABSTRACT
Postoperative nausea and vomiting are common complications of anaestnesia. This double-blind clinical trial assessed the incidence of nausea and vomiting after cataract surgery with intravenous anaesthesia in 100 patients randomly assigned to preinduction placebo (saline), metoclopramide (10 mg), dexamethasone (8 mg) or the 2 drugs combined. The incidence of nausea in the recovery room was 44% with placebo, 20% with metoclopramide, 16% with dexamethasone and 8% with the combination. The incidence of vomiting was 20%, 4%, 4% and 0% respectively in the 4 groups. Metoclopramide plus dexamethasone combination significantly decreased nausea and vomiting both in the recovery room and 24 hours afterwards and is recommended for high-risk groups, especially in outpatient surgeries.
Subject(s)
Antiemetics/therapeutic use , Dexamethasone/therapeutic use , Metoclopramide/therapeutic use , Postoperative Nausea and Vomiting/prevention & control , Preanesthetic Medication/methods , Premedication/methods , Aged , Analysis of Variance , Cataract Extraction/adverse effects , Chi-Square Distribution , Double-Blind Method , Drug Therapy, Combination , Female , Humans , Incidence , Iran/epidemiology , Male , Middle Aged , Postoperative Nausea and Vomiting/epidemiology , Postoperative Nausea and Vomiting/etiology , Treatment OutcomeABSTRACT
Postoperative nausea and vomiting are common complications of anaesthesia. This double-blind clinical trial assessed the incidence of nausea and vomiting after cataract surgery with intravenous anaesthesia in 100 patients randomly assigned to preinduction placebo [saline], metoclopramide [10 mg], dexamethasone [8 mg] or the 2 drugs combined. The incidence of nausea in the recovery room was 44% with placebo, 20% with metoclopramide, 16% with dexamethasone and 8% with the combination. The incidence of vomiting was 20%, 4%, 4% and 0% respectively in the 4 groups. Metoclopramide plus dexamethasone combination significantly decreased nausea and vomiting both in the recovery room and 24 hours afterwards and is recommended for high-risk groups, especially in outpatient surgeries
