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Sci Rep ; 7(1): 12571, 2017 10 03.
Article in English | MEDLINE | ID: mdl-28974740

ABSTRACT

Anserine/carnosine supplementation improves cerebral blood flow and verbal episodic memory in elderly people, as we previously reported. Anserine's buffering activity is superior to that of carnosine at neutral pH. In human sera, carnosine but not anserine is rapidly cleaved by carnosinase, limiting its effectiveness. This study examined the effects of anserine on AßPPswe/PSEN1dE9 Alzheimer's disease (AD) model mice over 18-months old, an age at which these mice exhibit detectable memory deficits. We found that 8 weeks of anserine treatment completely recovered the memory deficits, improved pericyte coverage on endothelial cells in the brain, and diminished chronic glial neuroinflammatory reactions in these mice. These results suggest that anserine (beta-alanyl-3-methyl-L-histidine) supplementation improved memory functions in AD-model mice by exerting a protective effect on the neurovascular units, which are composed of endothelial cells, pericytes, and supporting glial cells.


Subject(s)
Alzheimer Disease/drug therapy , Anserine/administration & dosage , Presenilin-1/genetics , Spatial Memory/drug effects , Aging/drug effects , Aging/pathology , Alzheimer Disease/pathology , Amyloid beta-Peptides/genetics , Animals , Brain/drug effects , Brain/pathology , Dipeptidases/genetics , Disease Models, Animal , Endothelial Cells/drug effects , Humans , Mice , Neuroglia/drug effects , Neuroglia/pathology , Pericytes/drug effects
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