ABSTRACT
The precision of the existing methods for evaluation of compartmental models may not be warranted if the plasma curve is irregular due to enterohepatic recycling of the substance during its elimination. In this work a new approach is proposed which involves the assessments of rate-constants using combined cross-sectional and time-series data. As (C0-Cpl) means the concentration of the drug in the environmental compartment, the (Formula: see text) equation is valid for the change in the plasma concentration level. Calculating the correlation coefficients (r) for the Cpl and (C0-Cpl) data-pairs from the cross-sectional data, in this case the time-derivatives of these correlation coefficients are equal to the rate constants.
Subject(s)
Enterohepatic Circulation , Pharmaceutical Preparations/blood , Animals , Intestinal Absorption , Kinetics , Mathematics , Pharmaceutical Preparations/metabolism , Stochastic ProcessesABSTRACT
Classical acupuncture concept is based on the vague, undefinable idea of energy. In our contemporary molecular biology, useful energy is considered to be stored in the macroerg phosphate compounds, e.g. in ATP, while (through the citrate cycle) CO2 is exhaled by the living cells of the body. In Hungary, a small and supersensitive CO2 detecting instrument was invented in 1976. Its sensitivity starts at 0.01 millionth of a gram CO2. In this study first the interrelationships between skin respiration, electrical skin resistance and skin temperature at the acupuncture point (AP) and at the adjacent skin area were investigated. The measured characteristics deviate, in spite of the distance of 1-2 centimeters. It is reasonable to suppose that in the maximum 52% the capillary CO2 tension at the AP reflects in the skin respiration data.
Subject(s)
Acupuncture Therapy , Carbon Dioxide/metabolism , Skin/metabolism , Electric Conductivity , Humans , Oxygen Consumption , Skin Physiological Phenomena , Skin TemperatureABSTRACT
The authors measured electrical resistance of skin to define the sensory loss. A significant increase of the skin resistance was observed in the zone of sensory loss, as compared with the skin surfaces of normal innervation. The sensory map, sweating map (ninhydrine test) and the skin resistance map were also compared by the authors. The main advantages of the electrical skin resistance test are that it is a quantitative one, and takes less time than the other methods.
