[Variability of short tandem repeats on the human Y chromosome]. / Izmenchivost' korotkikh tandemnykh povtorov Y-khromosomy cheloveka.

Nine rare (biallelic) mutations and six short tandem repeats (STR) mapping to the nonrecombining portion of the Y chromosome were genotyped in 734 males from different geographical regions inhabited by the contemporary Armenian population. The analysis of molecular variance (AMOVA) showed that 48.9% of total STR genetic variation was explained by the differences between the haplogroups isolated based on biallelic polymorphism, whereas only 1.3% of genetic variation could be attributed to the differences between the geographic groups.

[Genetic and ecologic factors of the variability of growth and development rates in postnatal human ontogeny]. / Geneticheskie i ékologicheskie faktory izmenchivosti tempov rosta i razvitiia v postnatal'nom ontogeneze cheloveka.

The contribution of genetic and ecological (high-altitude, urban-rural) factors into variability of the level of somatic development in different stages of pubertal development (7-17 years) of the male ontogeny was studied. It was found, that realization of genetic potential of growth and development in children and adolescents is not substantially influenced by high-altitude locations, but by ecological differences between urban and rural communities, induced by socioeconomic conditions.

[Succession in the morphological organization in human postnatal ontogeny]. / Preemstvennost' morfologicheskoi organizatsii v postnatal'nom ontogeneze cheloveka.

Preserving morphological organization succession in the human postnatal ontogenesis is studied in the growth processes in 7-17 years old boys. Canonical variables are separated by canonical correlation method, which are those maximally correlated morphological structures relating to each other hierarchically: body--head, body trunk--limbs, brain--face. It is shown that morphological organization succession is provided by preserving the stable level of interdependence between morphological structures, which are under relatively independent genetical control. The stability of this interdependence in disturbed only during the "critical phase" of adolescent spurt, which is characterized by maximal rate of morphofunctional development. After this phase initial level of the interdependence is restored.

[Chronogenetic control or the continuity of morphological organization during postnatal ontogenesis of man]. / Khronogeneticheskii kontrol' preemstvennosti morfologicheskoi organizatsii v postnatal'nom ontogeneze cheloveka.

Chronological peculiarities of genetic regulation of growth processes in morphological structures of postcranial skeleton ("body") and cranium ("head") were studied at different phases of peripubertal stage of boys ontogenesis. The component partitioning of the phenotype variance of individual scores of the structures considered revealed relative autonomy of chronogenetic systems controlling morphogenesis in the "body" and the "head". Succession of morphological organization is ensured by the stable level of correlation between morphological structures analysed. Raise in correlation is registered at the "critical" phase (13-14 years) which is connected with the "switching on" genetic programme of growth processes control in the adolescent period of human postnatal ontogenesis.

[Genetic determination of growth processes in the peripubertal period of human ontogeny]. / Geneticheskaia determinatsiia rostovykh protsessov v peripubertatnoi stadii ontogeneza cheloveka.

Chronological peculiarities of genetic determination of three factors of physical development in different phases of peripubertal stage of human ontogenesis were studied. The differences between sexes are explained by the hypothesis of mutual "clearing off" of X-linked genes' effects. This hypothesis is confirmed by the coincident dynamics of two indices--of additive genetic effects in boys and of nonlinear genetic effects in girls. The results point to autonomous nature of genetic determination of head's morphological structures, which is more expressed in boys. The component partitioning of the phenotype variance of the individual scores of linear discriminant functions revealed steady decrease across the peripubertal stage in the level of genetic determination of the variability of children's belonging to the different age periods. In the whole, the results indicate the existence of marked genetic determination of physique's growth and development in a stage under study of human ontogenesis.

[Classification of the peripubertal stage of ontogeny in girls: a multivariate statistical solution]. / Klassifikatsiia peripubertatnogo étapa ontogeneza devochek: mnogomernoe statisticheskoe reshenie.

Using the cluster analysis of objects in the space of physique factors the objective classification of peripubertal stage of ontogenesis in girls has been constructed. The factors were obtained by factor analysis of 26 anthropometric traits from a joint sample of girls aged 7 to 17 years. Four age groups (7-9, 10-11, 12-13, 14-17 years) distinguished by the factors and by the informative criteria of physique in total have been picked out. The diagnostic ability of the linear discriminant functions constructed by the stepwise discriminant analysis averages 80.0%. This level is in the limits determined in resolving problems of classification by using the anthropometric traits.

[Age dynamics of sex differences according to integral indices of habitus in 7 to 17-year-old children]. / Vozrastnaia dinamika polovykh razlichii po integral'nym pokazateliam teloslozheniia u detei 7-17 let.

Using analysis of major components with varimax-rotation, factor analysis of 26 anthropometric parameters has been performed in 1,100 children of both sex at the age of 7-17 years. Three orthogonal components are distinguished, embracing 76.6% of total variance. The first factor--the component of general size; the second and the third factors characterize variability connected with differentional processes. After calculation of individual values of the factors, the main statistical parameters of the body integral indices are defined for all age-sex groups. Convergence of the component values of the total size is observed, when comparing cohorts of boys and girls at the conclusive stages of ontogenesis studied. As for the two other integral parameters, the boys differ from the girls nearly in all age groups; the second factor demonstrates more differences in younger, and the third factor--in older age.

[Multivariate approach to the analysis of the growth processes in the peripuberty period of human ontogeny]. / Mnogomernyi podkhod k analizu rostovykh protsessov v peripubertatnyi period ontogeneza cheloveka.

Factor analysis by principal components with the Warimax rotation has been conducted on 26 anthropometric traits of 2200 children aged 6.75 to 17.25. Mean values of traits have been calculated at half-year intervals within each sex. Two orthogonal components accounting 96.5% of the total variation have been chosen. Individual factor values have been analysed to determine their relationship with age. The classification of objects is constructed by the cluster analysis in the space of factors. Four different morphological types within each sex have been found. The age limits between the revealed clusters differ for both sexes.