ABSTRACT
BACKGROUND: Carpal tunnel syndrome is a debilitating neuropathy affecting millions of individuals. Although there are published reports of familial associations of carpal tunnel syndrome, the molecular mechanisms are unknown. OBJECTIVE: To determine the prevalence and potential role of the chromosome 17 microdeletion associated with hereditary neuropathy with liability to pressure palsies in patients diagnosed as having carpal tunnel syndrome. DESIGN: Prospective study. PATIENTS AND METHODS: Since hereditary neuropathy with liability to pressure palsies may present as carpal tunnel syndrome, we evaluated 50 patients with idiopathic carpal tunnel syndrome for hereditary neuropathy with liability to pressure palsies. RESULTS: No hereditary neuropathy with liability to pressure palsies deletions were detected. CONCLUSION: Molecular genetic testing for hereditary neuropathy with liability to pressure palsies in patients with idiopathic carpal tunnel syndrome is of limited value.
Subject(s)
Carpal Tunnel Syndrome/genetics , Carpal Tunnel Syndrome/physiopathology , Chromosome Deletion , Tangier Disease/genetics , Adult , Aged , Carpal Tunnel Syndrome/epidemiology , Chromosomes, Human, Pair 17 , Female , Humans , Male , Middle Aged , Prevalence , Risk Factors , Tangier Disease/epidemiology , Tangier Disease/physiopathologySubject(s)
Anesthesia , Informed Consent/legislation & jurisprudence , Anesthesia/methods , Humans , Risk Factors , United StatesABSTRACT
The histologic appearance of 14 chicken flexor tendon repair sites with a defect in the tendon sheath was compared with 14 covered by fascia patch grafts. Half the animals (seven with and seven without the patch) were studied 3 weeks after surgery and the other half 8 weeks after surgery. The qualitative microscopic examination showed that the area of healing was better organized with less restrictive-appearing adhesions when the sheath defect was grafted.
Subject(s)
Fascia/transplantation , Tendons/surgery , Animals , Chickens , Fascia/anatomy & histology , Fibroblasts/pathology , Macrophages/pathology , Postoperative Complications , Tendons/pathology , Tissue Adhesions/etiology , Tissue Adhesions/pathology , Wound HealingABSTRACT
Forty-five stemless Proplast-covered silicone rubber trapezium implants were used in 40 patients after trapeziectomy for either osteoarthritis, rheumatoid arthritis, or trauma. Three implants were later removed from two patients because of traumatic dislocations. One implant was removed from a patient after trauma because of persistent pain. Five patients were followed from 40 to 44 months; nine patients were followed from 31 to 39 months; 15 patients were followed from 20 to 29 months; six patients were followed from 14 to 19 months; five patients were followed from 6 to 9 months. The average follow-up time was 24 7/10 months. Before surgery 5% of the patients had continuous spontaneous pain, 35% of the patients had pain with all motion, and 60% of the patients had pain with limited normal daily use. At this time of our report, 65% of the patients are without symptoms, 21% of the patients have slight intermittent pain, and 14% of the patients have pain with strenuous use only. Tripod pinch improved 243% in male patients and 113% in female patients. All patients have good circumduction and metacarpophalangeal (MP) and interphalangeal (IP) joint motion. The stemless feature permits relatively free metacarpal joint motion without great stress being applied to the capsule that is covering the implant.
