Subject(s)
Breast Diseases , Breast , Skin , Aged , Breast/metabolism , Breast/pathology , Breast Diseases/metabolism , Breast Diseases/pathology , Female , Humans , Keratosis/metabolism , Keratosis/pathology , Skin/metabolism , Skin/pathologyABSTRACT
The association of syringocystadenoma papilliferum (SCAP) with verrucous carcinoma (VC) of the skin in the same lesion is a rare, but well-documented event. Although human papillomaviruses (HPV) have been proposed to have an etiologic role in the development of the verrucous proliferations associated with SCAP, most of the immunohistochemical and molecular studies have failed to show the presence of their genomic material in these lesions. We report a series of four cases of SCAP associated with VC in anogenital lesions. In two of the cases, we demonstrated the presence of the BRAF V600E mutation by polymerase chain reaction and immunohistochemistry, both in the glandular and in the squamous component. No HPV-related histopathologic changes were found, nor could the presence of viral DNA be showed.
Subject(s)
Carcinoma, Verrucous , Mutation, Missense , Neoplasms, Second Primary , Proto-Oncogene Proteins B-raf , Sweat Gland Neoplasms , Tubular Sweat Gland Adenomas , Aged , Aged, 80 and over , Amino Acid Substitution , Carcinoma, Verrucous/genetics , Carcinoma, Verrucous/metabolism , Carcinoma, Verrucous/pathology , Humans , Male , Middle Aged , Neoplasms, Second Primary/genetics , Neoplasms, Second Primary/metabolism , Neoplasms, Second Primary/pathology , Proto-Oncogene Proteins B-raf/genetics , Proto-Oncogene Proteins B-raf/metabolism , Sweat Gland Neoplasms/genetics , Sweat Gland Neoplasms/metabolism , Sweat Gland Neoplasms/pathology , Tubular Sweat Gland Adenomas/genetics , Tubular Sweat Gland Adenomas/metabolism , Tubular Sweat Gland Adenomas/pathologyABSTRACT
The presence of CD30 cells in cutaneous lymphomas has come to prominence in recent years as a potential diagnostic and therapeutic marker. In primary cutaneous marginal zone B-cell lymphomas, the presence of large CD30 cells with Hodgkin-like features and their significance have not yet been studied. Here we describe the main clinical, histologic, immunophenotypic, and molecular characteristics of 13 cases of primary cutaneous marginal zone lymphomas featuring >10% of CD30 large cells, and analyze their relationship with histologic and clinical progression of the disease and with other morphologic and immunophenotypic features. We report 10 male and 3 female patients, 4 with early-local disease and 8 with locoregional advanced disease without extracutaneous involvement but with a high relapse rate of 69%. We describe an association between a high level of CD30 expression and disease progression, with increased clinical recurrence in cases with >15% of CD30 cells. We also discuss the differential diagnosis with other cutaneous and systemic lymphomas, especially Hodgkin lymphoma.
Subject(s)
Ki-1 Antigen/biosynthesis , Lymphoma, B-Cell, Marginal Zone/pathology , Skin Neoplasms/pathology , Adult , Aged , Aged, 80 and over , Biomarkers, Tumor/analysis , Female , Humans , Ki-1 Antigen/analysis , Male , Middle AgedABSTRACT
We describe a series of 9 patients with Epstein-Barr virus (EBV)-positive mucocutaneous lymphoproliferative lesions that broadens the concept of EBV-positive mucocutaneous ulcer. We report 5 female and 4 male patients, with an average age of 74 years (range, 55 to 87 y), 2 of whom were HIV-positive. The lesions were located in the oropharynx, skin, and rectal and/or genital mucosa. Histopathologically, 6 cases showed a polymorphic pattern and 3 had a monomorphic and diffuse one, with angiotropism in 4 cases (2 each with the polymorphic and monomorphic patterns). Three of the cases expressed PDL1. In addition to its presence in the neoplastic lymphoid cells, EBV was also detected in adjacent epithelial cells in an oropharyngeal lesion. All cases responded to local therapy or adapted systemic chemotherapy in selected cases. This series extends the spectrum of this disorder to include some HIV-positive cases, patients with multiple lesions confined to a single anatomic area, lesions with an angiocentric pattern, and some cases with monomorphous large-cell cytology. We discuss the differential clinicopathologic diagnosis of this disorder and that of classic EBV large B-cell lymphoma.
Subject(s)
Epstein-Barr Virus Infections/complications , Mucous Membrane/virology , Oral Ulcer/virology , Skin Ulcer/virology , Aged , Aged, 80 and over , Epstein-Barr Virus Infections/pathology , Female , Humans , Male , Middle Aged , Mucous Membrane/pathology , Oral Ulcer/pathology , Skin Ulcer/pathologyABSTRACT
BACKGROUND: Mammary Paget disease and extramammary Paget disease (EMPD) have different prognoses. Because they are indistinguishable on histopathological grounds, they must be distinguished on a topographical basis. OBJECTIVE: To study cases of Paget disease of the breast, which show similarities to EMPD. METHODS: Cases were selected by 2 different approaches: (1) those with an exceptionally good evolution and no evidence of subjacent tumor and (2) those expressing MUC5AC. RESULTS: Five cases were collected. All cases showed an indolent behavior with a known long clinical history in 2 cases (9 and 25 years, respectively) and a long follow-up in all cases but one (4-8 years). In all cases but one, surgery was performed, and no parenchymal tumor was found (either intraductal or infiltrating). All cases expressed cytokeratin 7 and MUC5AC without expression of MUC2, S100, or p40. LIMITATIONS: The short number of cases is a limitation of this study. In addition, case 5 is recent, so we have a very short follow-up. CONCLUSIONS: Some cases of mammary Paget disease behave like EMPD with slow progression and with no underlying associated tumor. Immunoexpression of MUC5AC might be a clue to identify them.
Subject(s)
Breast Neoplasms/pathology , Paget Disease, Extramammary/pathology , Paget's Disease, Mammary/pathology , Aged , Aged, 80 and over , Biomarkers, Tumor/analysis , Biopsy , Breast Neoplasms/chemistry , Breast Neoplasms/surgery , Diagnosis, Differential , Disease Progression , Female , Humans , Immunohistochemistry , Middle Aged , Mucin 5AC/analysis , Paget Disease, Extramammary/chemistry , Paget Disease, Extramammary/surgery , Paget's Disease, Mammary/chemistry , Paget's Disease, Mammary/surgery , Predictive Value of Tests , PrognosisABSTRACT
INTRODUCTION: Cutaneous regeneration, fractional laser, medical device, cellular proliferation cutaneous changes linked to photoaging are currently treated with physical treatments, such as fractional laser, which may induce epidermal alteration. OBJECTIVE: To determine the efficacy and safety of a regenerative serum (Matricium® , Laboratoire Bioderma, France) after laser procedure. METHODS: Prospective, double-blind, controlled, and randomized study in subjects with photoaged skin. The regenerative serum of treatment was used after a fractional laser session twice daily for 2 months on 1 side of the face and the placebo on the other side. The main variable to determine efficacy was the improvement of clinical signs and histological and immunological results. RESULTS: A superior quality of epidermal regeneration on the treated side compared to the placebo side was observed. Likewise, a superior and faster clinical improvement on static wrinkles was observed on the hemiface on which the regenerative serum was used. After 60 days, the investigator and the subjects observed a moderate to significant improvement of the skin on the treated side and a mild to moderate improvement on the placebo side. Histological examinations showed a superior thickness of epidermis and higher cellular proliferation rate (Ki67 markers) as well as a superior thickness of dermis with higher increase in elastin density with the regenerative serum compared to placebo. CONCLUSION: The use of the regenerative serum after fractional laser on the face accelerated and improved the cutaneous regeneration on both the clinical and histological level and maximized the benefits of the laser procedure.
Subject(s)
Epidermis/physiology , Hyaluronic Acid/pharmacology , Laser Therapy , Lasers, Solid-State/therapeutic use , Regeneration/drug effects , Skin Aging/drug effects , Aged , Double-Blind Method , Epidermis/drug effects , Epidermis/radiation effects , Face , Female , Humans , Middle Aged , Prospective Studies , Regeneration/radiation effects , Rejuvenation , Skin Aging/pathology , Skin Aging/radiation effectsABSTRACT
Pilomatrix carcinoma is a rare malignant tumor that originates from hair matrix cells. It is not usually considered in a differential diagnosis owing to its low incidence. We present a case of this uncommon entity and review the literature.
Subject(s)
Facial Neoplasms/diagnosis , Hair Diseases/diagnosis , Skin Neoplasms/diagnosis , Aged, 80 and over , Biopsy , Diagnosis, Differential , Humans , MaleABSTRACT
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