Subject(s)
Factor VII Deficiency/blood , Adult , Aged , Antigens/analysis , Child , Factor VII/analysis , Factor VII/genetics , Factor VII/immunology , Factor VII Deficiency/genetics , Female , Humans , Male , Pedigree , Prothrombin TimeSubject(s)
Hemolytic-Uremic Syndrome/drug therapy , Streptokinase/therapeutic use , Adolescent , Adult , Female , HumansSubject(s)
Factor VII Deficiency/genetics , Aged , Factor VII/genetics , Factor VII Deficiency/blood , Female , Humans , Male , Pedigree , Prothrombin TimeABSTRACT
In four healthy subjects with Factor XII levels equal to or below 50% (selected at random from 100 persons) the release of Kallikrein was studied in order to establish the relationship between the above data and those found in four Hageman trait carriers showing levels of Factor XII above the lowest normal limits. It was found that for similar amounts of Hageman activity three of the carriers showed significantly less release of Kallikrein than the control subjects in whom it was normal. The conclusion was reached that the additional determination of the amount of Kallikrein released may be of value in the detection of carriers of the Hageman trait.
Subject(s)
Factor XII Deficiency/blood , Factor XII/analysis , Heterozygote , Kallikreins/blood , Factor XII Deficiency/enzymology , Humans , Kallikreins/antagonists & inhibitorsABSTRACT
This report describes two people in a family with Hageman trait (homozygotes) (Factor XII = 0.06%). In addition eight family members were studied to evaluate the inheritance of this congenital deficiency. A study of the Kallikrein-Kininogen system induced by the fragments of Factor XII was carried out. It is concluded that the inheritance is as described by Veltkamp and that the Kallikrein release from the prekallikreinogen (Fletcher factor) "in vitro" is related to the amount of Factor XII procoagulant protein.
