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J Periodontal Res ; 51(5): 604-12, 2016 Oct.
Article in English | MEDLINE | ID: mdl-26667347

ABSTRACT

BACKGROUND: We aimed to detect the role of obesity on the healing response to periodontal therapy in terms of serum lipids, C-reactive protein (CRP) and both serum and gingival crevicular fluid adipocytokines. MATERIAL AND METHODS: Thirty patients with periodontitis with (CPO) (n = 15) and without (n = 15) obesity and 15 healthy controls were included. Serum high-density lipoprotein, low-density lipoprotein, triglyceride, CRP levels and levels of adiponectin, interleukin (IL)-6, tumor necrosis factor (TNF)-α and IL-10 were evaluated before and 3 mo after initial periodontal therapy. Clinical periodontal measurements were also recorded at baseline and 3 mo. RESULTS: Periodontal parameters improved significantly in both periodontitis groups with or without obesity (p < 0.05) with no significant difference in terms of gain clinical attachment level (p > 0.05) and change in numbers of sites with probing depth ≥ 4 mm. High-density lipoprotein significantly increased in both groups (p > 0.05). CRP decreased significantly solely in the normal weight group. IL-6, IL-10 and TNF-α levels in gingival crevicular fluid improved significantly based on therapy in both groups (p < 0.05). Only TNF-α decreased significantly in the CPO, while adiponectin and IL-10 in addition to TNF-α improved significantly in the group of patients with periodontitis without obesity. CONCLUSION: Patients with CPO respond to periodontal therapy as well as the non-obese controls. This similar response is accompanied with consistent adipokine levels in gingival crevicular fluid. However, obesity affects the CRP and serum adipocytokine levels in response to therapy.


Subject(s)
Adipokines/analysis , C-Reactive Protein/analysis , Gingival Crevicular Fluid/chemistry , Lipids/blood , Obesity/metabolism , Periodontitis/therapy , Adiponectin/analysis , Adult , Cytokines/analysis , Dental Plaque Index , Dental Scaling , Female , Humans , Interleukin-10/analysis , Interleukin-6/analysis , Lipoproteins, HDL/blood , Lipoproteins, LDL/blood , Male , Middle Aged , Periodontal Attachment Loss/therapy , Periodontal Index , Periodontal Pocket/therapy , Root Planing , Triglycerides/blood , Tumor Necrosis Factor-alpha/analysis
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