ABSTRACT
BACKGROUND: Exercise is widely touted as an effective intervention to optimize health and well-being after high-dose chemotherapy and hematopoietic stem cell transplantation. â©. OBJECTIVES: This article reports attrition, compliance, adherence, and progression from the strength training arm of the single-blind randomized, controlled trial Strength Training to Enhance Early Recovery (STEER). â©. METHODS: 37 patients were randomized to the intervention and participated in a structured strength training program introduced during hospitalization and continued for six weeks after release. Research staff and patients maintained exercise logs to document compliance, adherence, and progression. â©. FINDINGS: No patients left the study because of burden. Patients were compliant with completion of exercise sessions, and their adherence was high; they also progressed on their exercise prescription. Because STEER balances intervention effectiveness with patient burden, the findings support the likelihood of successful translation into clinical practice.
Subject(s)
Exercise Therapy/methods , Fatigue/etiology , Fatigue/therapy , Hematopoietic Stem Cell Transplantation/adverse effects , Hematopoietic Stem Cell Transplantation/psychology , Patient Compliance/psychology , Patient Compliance/statistics & numerical data , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Quality of Life , Random Allocation , United StatesABSTRACT
Small molecules, such as ferrocenemethanol (FcMeOH) and O2, that are capable of quenching the Ru(bpy)3(2+) excited state via energy or electron transfer can be quantitatively detected in a bipolar electrochemical cell based on the attenuation of steady-state electrogenerated chemiluminescence (ECL). FcMeOH quenches ECL generated by the Ru(bpy)3(2+) oxalate coreactant system, exhibiting a linear dependence on [FcMeOH] with a Stern-Volmer slope of 921 M(-1), corresponding to a quenching rate constant of 2 × 10(9) M(-1) s(-1). We used the bipolar ECL quenching platform to measure dissolved O2 and validated the results using a standard Clark electrode. The detection limit for local [O2] measured using ECL quenching was found to be 300 ppb. This work opens up the possibility of utilizing ECL quenching at bipolar electrodes for a wide range of applications.
