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1.
Transpl Infect Dis ; 13(2): 178-81, 2011 Apr.
Article in English | MEDLINE | ID: mdl-20738834

ABSTRACT

Fungal pathogens are increasingly encountered after renal transplantation. Aspergillus causes significant morbidity and mortality in transplant patients. Fungal thyroiditis is a rare occurrence owing to unique features of the thyroid gland. Most cases are caused by Aspergillus species and have been described in immunocompromised patients. Presentation may be identical with that of subacute thyroiditis, in which hyperthyroidism features and painful thyroid are the prominent findings. Diagnosis can be ascertained by fine-needle aspiration of thyroid showing branching hyphae of Aspergillus. We describe a renal transplant patient who developed Aspergillus thyroiditis as part of a disseminated infection successfully treated with voriconazole.


Subject(s)
Aspergillosis/etiology , Kidney Transplantation/adverse effects , Thyroiditis/microbiology , Antifungal Agents/administration & dosage , Antifungal Agents/therapeutic use , Aspergillosis/drug therapy , Aspergillosis/pathology , Caspofungin , Echinocandins/administration & dosage , Echinocandins/therapeutic use , Humans , Lipopeptides , Pyrimidines/administration & dosage , Pyrimidines/therapeutic use , Thyroid Gland/microbiology , Thyroiditis/drug therapy , Thyroiditis/pathology , Triazoles/administration & dosage , Triazoles/therapeutic use , Voriconazole
2.
Acta Chir Belg ; 107(5): 570-1, 2007.
Article in English | MEDLINE | ID: mdl-18074924

ABSTRACT

Cystic hydatid disease is caused by the Echinococcus granulosus parasite. Most frequently, cysts develop in liver and lung. The breast is rarely a primary site of the hydatid cyst. A case of hydatid cyst of the breast is presented, the diagnosis of which was missed both pre-operatively and intra-operatively.


Subject(s)
Breast Diseases/diagnosis , Echinococcosis/diagnosis , Adult , Albendazole/therapeutic use , Anthelmintics/therapeutic use , Breast/parasitology , Breast Diseases/diagnostic imaging , Breast Diseases/drug therapy , Breast Diseases/parasitology , Breast Diseases/surgery , Combined Modality Therapy , Echinococcosis/drug therapy , Echinococcosis/surgery , Female , Humans , Ultrasonography, Mammary
3.
Cytopathology ; 17(5): 267-74, 2006 Oct.
Article in English | MEDLINE | ID: mdl-16961656

ABSTRACT

OBJECTIVE: The aims of this study were to evaluate the typing accuracy of conventional smear (CS), cell block (CB) preparations and combined use of both procedures (CS + CB) for the diagnosis of hepatic malignancies and to determine whether immediate on-site cytopathological evaluation improves the diagnostic yield of liver fine-needle aspiration cytology (FNAC). METHODS: Ultrasound-guided FNABs were performed on 323 consecutive cases with liver masses between December 2002 and December 2004. Histologically and/or clinically correlated 167 cases were included in the study. Preliminary FNAB results, results of CS, CB, and combined use of CS and CB were compared regarding diagnostic sensitivity, specificity, and accuracy for the diagnosis of malignancy. Subtyping accuracies of different methods were also compared. RESULTS: The sensitivity of on-site cytopathological examination and CS were both 92.8%. The sensitivity of CS + CB was slightly better than that of CB (93.5% versus 84.8%). Specificity of all procedures was achieved 100%. Diagnostic accuracy of on-site cytopathological evaluation, CS, CB, and CS + CB were 93.9%, 93.9%, 87.2%, and 94.5%, respectively. A specific subtype diagnosis of malignant tumours could be rendered accurately on the basis of preliminary diagnosis in 71%, CS in 75.4%, CB in 78.3% and combined approach in 92% of cases. In terms of typing accuracy, 87.5% of HCCs, 93.2% of adenocarcinomas, 92.3% of neuroendocrine carcinomas, 100% of lymphomas and 100% of other malignant tumours were correctly subclassified in the final cytopathological diagnosis. The agreement between preliminary diagnosis and final cytopathological diagnosis was 77.2%. CONCLUSION: With use of on-site cytopathological evaluation and combined use of CS and CB, the diagnostic accuracy of liver tumours approaches 100% and also significantly improve diagnostic and subtyping accuracy of liver malignancies.


Subject(s)
Biopsy, Fine-Needle , Histocytological Preparation Techniques , Liver Neoplasms/diagnosis , Liver/diagnostic imaging , Liver/surgery , Adolescent , Adult , Aged , Aged, 80 and over , False Negative Reactions , False Positive Reactions , Female , Humans , Liver/pathology , Male , Middle Aged , Reproducibility of Results , Sensitivity and Specificity , Ultrasonography
4.
Allergol Immunopathol (Madr) ; 33(2): 105-11, 2005.
Article in English | MEDLINE | ID: mdl-15808118

ABSTRACT

BACKGROUND: Apoptosis may be important in limiting airway eosinophilia. Treatment with leukotriene antagonists decreases the number of eosinophils in both peripheral blood and sputum. AIM: To assess the effect of montelukast on eosinophil apoptosis in a group of patients with mild persistent asthma (MPA) and to compare this effect with the apoptotic effect of fluticasone propionate (FP). METHODS: Randomly selected patients with MPA (n = 22) who had not taken anti-inflammatory therapy within the preceding 12 months were included in the study. The sputum induction procedure was performed and the patients were divided into two groups: group 1 (n = 10) received FP 250 microg/day and group 2 (n = 22) received montelukast 10 mg/day orally for 4 weeks. Sputum induction was repeated after the treatment period. The resulting cytospin slides were stained by Wright's stain and morphologic changes in apoptotic eosinophils were assessed by the use of light microscopy by two blinded expert pathologists. Serum soluble Fas ligand (sFasL) concentrations were measured by an ELISA method at baseline and after treatment in both groups, as well as in a group of healthy subjects. RESULTS: In within-group comparisons, the apoptotic ratio (AR) increased at the end of the study period in group 1 (p = 0.05). In the group treated with FP the ratio of sputum eosinophils significantly decreased (p = 0.02), and the AR significantly increased (p < 0.005). No differences were found in the two study groups in serum sFasL levels at the end of the treatment period compared with baseline values (p > 0.05). CONCLUSION: Our findings demonstrate that 4 weeks' treatment with a CysLT receptor antagonist (montelukast) resulted in an increase in eosinophil apoptosis comparable to that produced by FP, suggesting that induction of apoptosis may be a potential mechanism for the mode of action of CysLT receptor antagonists in asthma.


Subject(s)
Acetates/pharmacology , Anti-Asthmatic Agents/pharmacology , Apoptosis/drug effects , Asthma/drug therapy , Eosinophilia/drug therapy , Eosinophils/drug effects , Leukotriene Antagonists/pharmacology , Quinolines/pharmacology , Sputum/cytology , Acetates/therapeutic use , Adult , Androstadienes/pharmacology , Androstadienes/therapeutic use , Anti-Asthmatic Agents/therapeutic use , Anti-Inflammatory Agents/pharmacology , Anti-Inflammatory Agents/therapeutic use , Asthma/blood , Asthma/immunology , Asthma/pathology , Cyclopropanes , Eosinophilia/blood , Eosinophilia/immunology , Eosinophilia/pathology , Eosinophils/pathology , Fas Ligand Protein , Female , Fluticasone , Forced Expiratory Volume , Humans , Leukotriene Antagonists/therapeutic use , Male , Membrane Glycoproteins/blood , Middle Aged , Observer Variation , Quinolines/therapeutic use , Single-Blind Method , Sulfides , Treatment Outcome
5.
Allergol. immunopatol ; 33(2): 105-111, mar. 2005. ilus, tab
Article in En | IBECS | ID: ibc-037687

ABSTRACT

Background: Apoptosis may be important in limiting airway eosinophilia. Treatment with leukotriene antagonists decreases the number of eosinophils in both peripheral blood and sputum. Aim: To assess the effect of montelukast on eosinophil apoptosis in a group of patients with mild persistent asthma (MPA) and to compare this effect with the apoptotic effect of fluticasone propionate (FP). Methods: Randomly selected patients with MPA (n = 22) who had not taken anti-inflammatory therapy within the preceding 12 months were included in the study. The sputum induction procedure was performed and the patients were divided into two groups: group 1 (n = 10) received FP 250 mg/day and group 2 (n = 22) received montelukast 10 mg/day orally for 4 weeks. Sputum induction was repeated after the treatment period. The resulting cytospin slides were stained by Wright’s stain and morphologic changes in apoptotic eosinophils were assessed by the use of light microscopy by two blinded expert pathologists. Serum soluble Fas ligand (sFasL) concentrations were measured by an ELISA method at baseline and after treatment in both groups, as well as in a group of healthy subjects. Results: In within-group comparisons, the apoptotic ratio (AR) increased at the end of the study period in group 1 (p = 0.05). In the group treated with FP the ratio of sputum eosinophils significantly decreased (p = 0.02), and the AR significantly increased (p 0.05). Conclusion: Our findings demonstrate that 4 weeks’ treatment with a CysLT receptor antagonist (montelukast) resulted in an increase in eosinophil apoptosis comparable to that produced by FP, suggesting that induction of apoptosis may be a potential mechanism for the mode of action of CysLT receptor antagonists in asthma


Contexto: La apoptosis puede ser importante para limitar los eosinófilos de las vías respiratorias. El tratamiento con antagonistas de los leucotrienos reduce el número de eosinófilos tanto en la sangre periférica como en el esputo. Objetivo: Evaluar el efecto del montelukast (M) sobre la apoptosis eosinofílica en un grupo de pacientes con asma leve persistente (ALP) para compararlo con el efecto apoptótico del propionato de fluticasona (PF). Métodos: Para el estudio se seleccionaron aleatoriamente pacientes con ALP (n = 22) que no habían recibido terapia antiinflamatoria durante los 12 meses previos. Tras proceder a la inducción del esputo, los pacientes se dividieron en dos grupos: uno recibió 250 mg/día de propionato de fluticasona (grupo 1, n = 10) y el otro 10 mg/día de M por vía oral (grupo 2, n = 12) durante 4 semanas. Tras el período de tratamiento se repitió la inducción del esputo. Los preparados resultantes obtenidos por citocentrifugación se tiñeron con colorante de Wright y dos patólogos expertos que desconocían el origen de las muestras las observaron al microscopio de luz para evaluar los cambios morfológicos de los eosinófilos apoptóticos. Se midieron las concentraciones séricas del ligando Fas soluble (sFasL) mediante el método ELISA antes y después del tratamiento en ambos grupos, midiéndose simultáneamente en un grupo de sujetos sanos. Resultados: Comparando los resultados en un mismo grupo, el índice apoptótico (IA) aumentó al final del período de estudio en el grupo 1 (p = 0,05). En el grupo tratado con PF, el índice de eosinófilos en el esputo disminuyó significativamente (p = 0,02), mientras que hubo un aumento significativo del IA (p 0.05). Conclusión: Nuestros hallazgos demuestran que un tratamiento de cuatro semanas con un antagonista de los receptores de Cis-LT, el montelukast, produce un aumento de la apoptosis eosinofílica comparable al que produce el propionato de fluticasona, lo que sugiere que la inducción de la apoptosis puede ser un mecanismo de acción de los antagonistas de los receptores de Cis-LT en el asma


Subject(s)
Adult , Humans , Acetates/pharmacology , Anti-Asthmatic Agents/pharmacology , Apoptosis , Asthma/drug therapy , Eosinophilia/drug therapy , Eosinophils , Leukotriene Antagonists/pharmacology , Quinolones/pharmacology , Acetates/therapeutic use , Androstadienes/pharmacology , Anti-Asthmatic Agents/therapeutic use , Anti-Inflammatory Agents/pharmacology , Asthma/blood , Eosinophilia/blood , Eosinophilia/immunology , Leukotriene Antagonists/therapeutic use , Membrane Glycoproteins , Quinolones/therapeutic use
6.
Arch Bronconeumol ; 41(2): 102-4, 2005 Feb.
Article in Spanish | MEDLINE | ID: mdl-15718006

ABSTRACT

Malignant melanoma involving the respiratory tract is nearly always metastatic. True primary tumors are very rare, and only approximately 28 cases have been reported in the literature. Extensive clinical and histopathological examinations are needed to ascertain that the lung is the primary site. We present the case of a 67-year-old man with an apparent primary malignant melanoma of the lung in the right lower lobe. We also review the literature.


Subject(s)
Lung Neoplasms/pathology , Melanoma/pathology , Neoplasms, Unknown Primary/pathology , Aged , Humans , Lung Neoplasms/secondary , Male , Melanoma/secondary
7.
Arch. bronconeumol. (Ed. impr.) ; 41(2): 102-104, feb. 2005. ilus
Article in Es | IBECS | ID: ibc-037486

ABSTRACT

El melanoma maligno que afecta al sistema respiratorio tiene un origen casi siempre metastásico y los tumores primarios verdaderos son muy frecuentes. En la bibliografía se han publicado aproximadamente 28 casos. Son necesarios estudios clínicos y anatomopatológicos detallados para considerar que el pulmón es la localización primaria del tumor. En este artículo se presenta el caso de un varón de 67 años de edad con un melanoma pulmonar maligno primario en el lóbulo inferior derecho. También se realiza una revisión de la bibliografía


Malignant melanoma involving the respiratory tract is nearly always metastatic. True primary tumors are very rare, and only approximately 28 cases have been reported in the literature. Extensive clinical and histopathological examinations are needed to ascertain that the lung is the primary site. We present the case of a 67-year-old man with an apparent primary malignant melanoma of the lung in the right lower lobe. We also review the literature


Subject(s)
Male , Aged , Humans , Melanoma/pathology , Lung Neoplasms/pathology , Neoplasms, Unknown Primary/pathology , Melanoma/secondary , Lung Neoplasms/secondary
8.
Neurochirurgie ; 50(2-3 Pt 1): 101-4, 2004 Jun.
Article in English | MEDLINE | ID: mdl-15213638

ABSTRACT

Primary brain tumors rarely metastasize outside of the central nervous system. A case of 37-year-old woman with a temporal lobe glial tumor which shows infratemporal and orbital invasion is presented. She had undergone a cranial operation because of temporal lobe epilepsy 8 years ago. Defects on the dura and bone flap were thought to be the mechanisms of the infratemporal fossa invasion. The case illustrates extra-axial metastasis of glioblastoma multiforme, an exceptional finding.


Subject(s)
Brain Neoplasms/secondary , Glioblastoma/secondary , Orbital Neoplasms/secondary , Temporal Lobe/pathology , Astrocytes/pathology , Brain Neoplasms/pathology , Brain Neoplasms/surgery , Dura Mater/pathology , Epilepsy, Temporal Lobe/surgery , Female , Glioblastoma/pathology , Glioblastoma/surgery , Humans , Magnetic Resonance Imaging , Middle Aged , Neurosurgical Procedures , Orbital Neoplasms/pathology , Orbital Neoplasms/surgery , Pons/pathology , Surgical Flaps/adverse effects , Temporal Lobe/surgery
11.
Bone Marrow Transplant ; 30(1): 45-7, 2002 Jul.
Article in English | MEDLINE | ID: mdl-12105777

ABSTRACT

There is an appreciable mortality associated with BMT in patients with SCID and advanced BCG infection. We present a girl with T-B+ SCID complicated by spina ventosa and disseminated BCG osteitis after receiving a fully matched sibling marrow transplant. Considerable progression characterised by two clinical activations and multiple pleural and perivertebral abscess formations occurred with conventional anti-mycobacterial chemotherapy. She finally recovered with full immune reconstitution after BMT and intensive treatment comprising five conventional and alternative agents that she received for 36 months. No side-effects and/or complications have been seen other than hearing loss.


Subject(s)
BCG Vaccine/adverse effects , Bone Marrow Transplantation/adverse effects , Severe Combined Immunodeficiency/complications , Tuberculosis/drug therapy , Tuberculosis/etiology , Antibiotics, Antitubercular/administration & dosage , Antineoplastic Agents/administration & dosage , Bone Marrow Transplantation/methods , Drug Therapy, Combination , Female , Humans , Infant , Mycobacterium tuberculosis , Severe Combined Immunodeficiency/therapy , Treatment Outcome , Tuberculosis/diagnosis
12.
Ann Oncol ; 12(7): 1011-3, 2001 Jul.
Article in English | MEDLINE | ID: mdl-11521785

ABSTRACT

BACKGROUND: Four cycles of AC have been accepted as the standard chemotherapy in breast cancer. In the present randomized study we aimed to assess the efficacy of adjuvant etoposide + cisplatin (EP) combination following four cycles of standard adriamycin + cyclophosphamide (AC) in premenopausal patients with operable breast cancer and axillary lymph node metastasis. PATIENTS AND METHODS: Premenopausal patients with positive axillary lymph nodes following curative modified radical mastectomy were randomized to either four cycles of AC (82 patients) or four cycles of AC + two cycles of EP (83 patients). RESULTS: Median follow-up is 72 months. All randomized and eligible patients are included in the analysis (AC: 80 patients, AC + EP: 78 patients). The five-year disease-free survival (DFS) for the AC + EP group was significantly better when compared to AC group (45.5% vs. 30.4%; P = 0.048). Again, the five-year overall survival (OS) of the whole group was in favor of AC + EP arm, though without statistical significance (68.6% vs. 59.1%; P = 0.247). CONCLUSION: Two cycles of EP following four cycles of AC decreased the relapse rate in operable breast cancer patients.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Breast Neoplasms/drug therapy , Breast Neoplasms/pathology , Adult , Antineoplastic Agents, Alkylating/administration & dosage , Antineoplastic Agents, Phytogenic/administration & dosage , Axilla , Chemotherapy, Adjuvant , Cisplatin/administration & dosage , Cyclophosphamide/administration & dosage , Disease-Free Survival , Doxorubicin/administration & dosage , Drug Administration Schedule , Etoposide/administration & dosage , Female , Humans , Lymphatic Metastasis , Middle Aged , Premenopause , Survival Analysis , Treatment Outcome
13.
Int Orthop ; 25(2): 123-6, 2001.
Article in English | MEDLINE | ID: mdl-11409451

ABSTRACT

Primary malignant lymphoma of bone (PLB) is an uncommon tumour. A survey of 278 primary malignant cases in our clinic showed that 20 cases of PLB were registered between 1986 and 1997. Fourteen of the 20 cases underwent surgical excision. The mean follow-up time was 36.3 months. The rate of response to treatment was 65% with a rate of complete recovery of 55%. The clinical stage of tumours correlated well with the prognosis. Our results seem worse than most of the series in the literature. A high proportion of stage IV disease and pathological fractures at presentation may be a factor.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bone Neoplasms/pathology , Bone Neoplasms/therapy , Cyclophosphamide/therapeutic use , Doxorubicin/therapeutic use , Lymphoma/pathology , Lymphoma/therapy , Orthopedic Procedures/methods , Prednisone/therapeutic use , Vincristine/therapeutic use , Adolescent , Adult , Aged , Biopsy, Needle , Bone Neoplasms/mortality , Combined Modality Therapy , Female , Follow-Up Studies , Humans , Lymphoma/mortality , Male , Middle Aged , Radiotherapy, Adjuvant , Registries , Survival Analysis , Tomography, X-Ray Computed , Treatment Outcome , Turkey
14.
J Neurosurg Sci ; 45(4): 224-7; discussion 227, 2001 Dec.
Article in English | MEDLINE | ID: mdl-11912475

ABSTRACT

A patient with an intradiploic epidermoid cyst of calvarium was presented. Head injury that may cause the inclusion of epidermal cells into the diploe of the bone was present in his medical history. Skull radiographs and cranial magnetic resonance imaging (MRI) demonstrated the tumor. The tumor was totally removed and the patient was discharged free of symptoms.


Subject(s)
Bone Diseases/etiology , Craniocerebral Trauma/complications , Epidermal Cyst/etiology , Parietal Bone , Adult , Bone Diseases/diagnosis , Bone Diseases/pathology , Bone Diseases/surgery , Craniotomy , Epidermal Cyst/diagnosis , Epidermal Cyst/pathology , Epidermal Cyst/surgery , Humans , Magnetic Resonance Imaging , Male , Parietal Bone/diagnostic imaging , Parietal Bone/pathology , Radiography
15.
Int Urol Nephrol ; 33(4): 617-8, 2001.
Article in English | MEDLINE | ID: mdl-12452610

ABSTRACT

Angiomyolipoma with extrarenal involvement is very uncommon. Herein we report a case of angiomyolipoma with lymph node involvement in a 17-year-old female. The diagnosis and treatment of the case is discussed.


Subject(s)
Angiomyolipoma/pathology , Carcinoma, Renal Cell/diagnosis , Kidney Neoplasms/pathology , Adolescent , Angiomyolipoma/diagnosis , Female , Humans , Kidney Neoplasms/diagnosis , Lymphatic Metastasis
16.
Am J Hematol ; 65(2): 99-104, 2000 Oct.
Article in English | MEDLINE | ID: mdl-10996825

ABSTRACT

This study evaluates the dysplastic hematological changes in nine patients with idiopathic thrombocytopenic purpura (ITP) in 11 attacks, before and after corticosteroid treatment. The pretreatment blood smears of patients with ITP, displayed more neutrophils with bizarre nuclei (P < 0.001), Döhle or Döhle-like inclusions (P < 0. 01), irregular distribution of granules (P < 0.05), hypo-agranulation (P < 0.05), pseudo-Pelger-Huet-like cells (P < 0. 01), and nuclei with chromatine clumping (P < 0.01) than the normal children. The eosinophils of ITP patients were also dysplastic, before treatment. The pretreatment diameter of the neutrophils and the percentage of macropolycytes were greater than those of the patients with viral infections and normal group (P < 0.05 for all). The percentage of neutrophils with bizarre nuclei and nuclei with chromatine clumping and the diameter of neutrophils and macropolycyte percentage increased with corticosteroid therapy (P < 0.01, < 0.01, < 0.01, and < 0.05, respectively). The neutrophil diameter, percentage of macropolycytes, and number of neutrophils with bizarre nuclei decreased within 1-4 weeks after the therapy was stopped. In the neutrophils of two patients, diploidy and hyperdiploidy were established before and on the last day of therapy, respectively, and diploidy reversed after therapy was stopped. In conclusion, ITP patients display dysplastic findings in both neutrophils and eosinophils before treatment and corticosteroids cause transient significant increase in some of the dysplastic changes in neutrophils.


Subject(s)
Adrenal Cortex Hormones/pharmacology , Diploidy , Purpura, Thrombocytopenic, Idiopathic/drug therapy , Purpura, Thrombocytopenic, Idiopathic/pathology , Adolescent , Adrenal Cortex Hormones/adverse effects , Adrenal Cortex Hormones/genetics , Cell Adhesion/drug effects , Cell Nucleus/drug effects , Cell Nucleus/pathology , Cell Nucleus/ultrastructure , Cell Size/drug effects , Child , Child, Preschool , Eosinophils/drug effects , Eosinophils/pathology , Female , Flow Cytometry , Humans , Infant , Male , Neutrophils/drug effects , Neutrophils/pathology , Neutrophils/ultrastructure , Purpura, Thrombocytopenic, Idiopathic/genetics
18.
Am J Kidney Dis ; 35(6): 1207-11, 2000 Jun.
Article in English | MEDLINE | ID: mdl-10845836

ABSTRACT

Renal complications of Castleman's disease are uncommon. Among the various renal disorders, including mesangial proliferative glomerulonephritis, membranous glomerulonephritis, and minimal change disease, nephrotic syndrome attributable to renal amyloidosis is very rarely reported. We report a case of mixed type of localized Castleman's disease complicated with nephrotic syndrome. Renal biopsy was performed. The deposition of AA amyloidosis was shown. After the removal of two mesenteric lymphoid masses, the proteinuria was gradually decreased and disappeared. Renal biopsy was repeated after 14 months, and, despite complete remission of nephrotic syndrome, no regression in amyloid deposition was found.


Subject(s)
Castleman Disease/surgery , Nephrotic Syndrome/therapy , Adult , Amyloidosis/etiology , Amyloidosis/therapy , Biopsy , Castleman Disease/complications , Follow-Up Studies , Humans , Kidney Diseases/etiology , Kidney Diseases/therapy , Male , Mesentery , Nephrotic Syndrome/etiology , Peritoneal Diseases/complications , Peritoneal Diseases/surgery , Proteinuria/etiology , Proteinuria/therapy , Remission Induction , Serum Amyloid A Protein/analysis
19.
Tumori ; 86(6): 489-91, 2000.
Article in English | MEDLINE | ID: mdl-11218194

ABSTRACT

We report on a de novo desmoid tumor of the posterior mediastinum with transdiaphragmatic extension in a 40-year-old man. The tumor was inoperable because of its location and the invasion of adjacent structures. Although extremely rare, desmoid tumors of the posterior mediastinum should be considered in the differential diagnosis of posterior mediastinal masses.


Subject(s)
Fibromatosis, Aggressive/diagnosis , Mediastinal Neoplasms/diagnosis , Adult , Diagnosis, Differential , Diaphragm , Fibromatosis, Aggressive/pathology , Humans , Male , Mediastinal Neoplasms/pathology
20.
Bull Hosp Jt Dis ; 58(2): 98-104, 1999.
Article in English | MEDLINE | ID: mdl-10509202

ABSTRACT

Seventy-two cases of giant cell tumor (GCT) of bone were diagnosed in our clinic between 1986 and 1998. The mean age of the patients was 35 (range: 11 to 63 years) and the female to male ratio was 1.3:1. Fifty-four percent of the cases had involvement about the knee (distal femur, upper tibia, and upper fibula). Four patients had a malignant form of the disease and another four had the disease before closure of the physis. There was no case of multicentric involvement. Nine patients presented with pathological fracture. Forty-seven patients had histological grading done. Twenty three (49%) had grade I, 17 (36%) had grade II, and seven (15%) had grade III disease. The mean follow-up time was 59.6 months (range: 24 to 142 months) for patients at least two years follow-up. There was a 33% complication rate.


Subject(s)
Bone Neoplasms/diagnosis , Bone Neoplasms/surgery , Carcinoma, Giant Cell/diagnosis , Carcinoma, Giant Cell/surgery , Adolescent , Adult , Age Distribution , Bone Neoplasms/epidemiology , Carcinoma, Giant Cell/epidemiology , Data Collection , Female , Humans , Incidence , Male , Middle Aged , Prognosis , Risk Factors , Sex Distribution , Survival Rate , Turkey/epidemiology
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