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1.
Eklem Hastalik Cerrahisi ; 27(3): 175-8, 2016 Dec.
Article in English | MEDLINE | ID: mdl-27902174

ABSTRACT

Herein we report a case of patellar aneurysmal bone cyst of a 32-year-old female patient who was admitted to our outpatient clinic due to the swelling on her left knee. She was describing no trauma history but increasing pain and that the mass was expanding gradually by the time. Although it occurs rarely in patella, evaluation by radiographic and magnetic resonance images revealed that the mass was due to the patellar aneurysmal bone cyst, which also destructed the surface of the joint. Although there was no impairment in the range of motion of the patient's left knee in the preoperative evaluation, because of the destruction, we performed total patellectomy and extensor mechanism reconstruction by Zaricznyj technique instead of curettage and grafting. The patient was satisfied with the procedure performed after the surgery and there was no complication in the follow-up.


Subject(s)
Bone Cysts, Aneurysmal/surgery , Patella/surgery , Adult , Bone Cysts, Aneurysmal/pathology , Female , Follow-Up Studies , Humans , Magnetic Resonance Imaging , Orthopedic Procedures/methods , Patella/pathology , Patient Satisfaction , Range of Motion, Articular/physiology , Turkey
2.
Rheumatol Int ; 32(2): 451-5, 2012 Feb.
Article in English | MEDLINE | ID: mdl-20024552

ABSTRACT

Churg-Strauss syndrome (CSS) is a rare type of necrotizing vasculitis affecting small to medium-sized vessels typically characterized by asthma, lung infiltrates, necrotizing granulomas and hypereosinophilia. Herein, we describe a case of CSS presenting severe and aggressive course. A 35-year-old male patient with weight loss, dyspepsia, dyspnea and hemoptysis was admitted. The laboratory analyses indicated a remarkable eosinophilia, elevated levels of serum total IgE and positive cANCA. Thorax CT findings were suggestive of alveolar hemorrhage. Bronchoalveolar lavage revealed alveolar hemorrhage with eosinophilia and transbronchial lung biopsy showed eosinophilic vasculitis. Cardiac enzymes were increased and murmurs were audible revealing cardiomyopathy proven by echocardiography. Pulse cyclophosphamide and methyl prednisolone was immediately started. On the 21st day, intestinal perforation developed and urgent surgery was performed. During a follow-up, although a radiological improvement was observed in the chest X-ray, cardiac failure, peripheral neuropathy and skin lesions developed and high-dose intravenous immunoglobulin and anti-TNF therapy (adalimumab) were applied. Despite the therapy, he died from heart failure and septicemia at 68th day of therapy.


Subject(s)
Churg-Strauss Syndrome/complications , Heart Failure/etiology , Hemorrhage/etiology , Intestinal Perforation/etiology , Peripheral Nervous System Diseases/etiology , Adult , Churg-Strauss Syndrome/diagnostic imaging , Churg-Strauss Syndrome/pathology , Fatal Outcome , Heart Failure/pathology , Hemorrhage/diagnostic imaging , Humans , Intestinal Perforation/pathology , Male , Peripheral Nervous System Diseases/pathology , Pulmonary Alveoli/blood supply , Radiography
3.
Ann Dermatol ; 22(4): 435-8, 2010 Nov.
Article in English | MEDLINE | ID: mdl-21165215

ABSTRACT

Sarcoidosis is a multisystem granulomatous disorder of an unknown etiology. Subcutaneous sarcoidosis is a rare manifestation of sarcoidosis, and plantar involvement is extremely rare and there is only one such case report in the medical literature. Herein we present an interesting case of a patient who was diagnosed as having subcutaneous sarcoidosis at a plantar localization because plantar involvement is extremely rare and also because of the successful outcome after performing intralesional corticosteroid therapy.

4.
Knee Surg Sports Traumatol Arthrosc ; 18(4): 540-2, 2010 Apr.
Article in English | MEDLINE | ID: mdl-19779895

ABSTRACT

We describe a case of a previously healthy 35-year-old man who presents with meniscal symptoms, and present the arthroscopic findings of a complicated tear of black lateral meniscus. Investigations revealed that he had underlying alkaptonuria, which was previously undiagnosed without any other findings. After the surgical treatment, the patient's complaints were alleviated and almost no complaints were registered, during the next follow-up.


Subject(s)
Ochronosis/complications , Tibial Meniscus Injuries , Adult , Alkaptonuria/complications , Arthroscopy , Follow-Up Studies , Humans , Male , Menisci, Tibial/pathology , Ochronosis/pathology , Prospective Studies , Treatment Outcome
7.
World J Surg Oncol ; 6: 138, 2008 Dec 30.
Article in English | MEDLINE | ID: mdl-19116008

ABSTRACT

BACKGROUND: Primary sternal malignant fibrous histiyocytoma (MFH) is highly rare. Effective treatment modality is surgical resection with wide margins. However, to date, the effects of radiotherapy or chemotherapy has not been clearly defined. CASE PRESENTATION: Herein, we aimed to present a 50-year old female patient with MFH occurred in the radiotherapy field who had had surgical procedure for breast cancer 19 years ago and had followed by radiotherapy. Neoadjuvant chemotherapy was applied for MFH due to cardiac and mediastinal vascular invasion. Wide resection was carried out for the mass after having been decreased in size following neoadjuvant chemotherapy. CONCLUSION: Neoadjuvant chemotherapy was an effective method. In planning the surgical resection, the size of the tumor before chemotherapy should be considered as the initial size and surgical margins should be determined accordingly.


Subject(s)
Bone Neoplasms/therapy , Histiocytoma, Malignant Fibrous/therapy , Radiotherapy/adverse effects , Sternum/radiation effects , Breast Neoplasms/radiotherapy , Chemotherapy, Adjuvant , Combined Modality Therapy , Female , Histiocytoma, Malignant Fibrous/pathology , Humans , Middle Aged
8.
Tumori ; 94(6): 892-7, 2008.
Article in English | MEDLINE | ID: mdl-19267115

ABSTRACT

Primary tumors of the heart are rarely seen. Cardiac angiosarcomas are malignant tumors that almost always have a poor prognosis. We describe a 29-year-old man with primary cardiac angiosarcoma with multiple site metastases. The therapeutic approach includes surgery, chemotherapy and radiotherapy alone or in combination. New techniques of radiotherapy and combined chemotherapeutic agents may relieve symptoms and prolong a patient's life. We discuss the diagnosis and treatment of cardiac angiosarcoma in the light of a case report.


Subject(s)
Heart Neoplasms/pathology , Hemangiosarcoma/pathology , Adult , Diagnosis, Differential , Heart Neoplasms/diagnostic imaging , Heart Neoplasms/therapy , Hemangiosarcoma/diagnostic imaging , Hemangiosarcoma/therapy , Humans , Male , Prognosis , Tomography, X-Ray Computed
9.
J Orthop Sci ; 12(5): 415-23, 2007 Sep.
Article in English | MEDLINE | ID: mdl-17909925

ABSTRACT

BACKGROUND: Secondary malignancies arising from benign bone tumors are rare. Their recognition and diagnosis are difficult, and their slow growth and late recurrence require long-term follow-up. In this study, malignant transformation rates of various histological types of benign cartilage-forming bone tumors in large series were evaluated. METHODS: Between 1986 and 2004, a retrospective analysis of 627 cartilage-forming benign bone tumors revealed that 32 patients had malignant transformation. Of the 32 patients, 14 had solitary osteochondromas, 10 had multiple osteochondromas, 6 had a solitary enchondroma, 1 had Ollier's disease, and 1 had Maffucci's syndrome. The patient with Ollier's disease had two chondrosarcomas, and one patient with multiple osteochondroma had three chondrosarcomas. The cases were included in the study only when complete clinical documentation, radiological records, and histological analyses were available. RESULTS: The rate of malignant transformation for cartilage-originating tumors was 5.1% (solitary osteochondromas 4.2%, multiple osteochondromas 9.2%, solitary enchondromas 4.2%). The average time between the initial diagnosis and malignant transformation was 9.8 years. The most common site of involvement was the proximal portion of the femur. The tumors generally were well differentiated. The mean follow-up period was 57.3 months. Five patients (15.6%) died of tumor recurrence or metastasis at an average of 20.6 months. One patient is alive with tumor at 104 months. CONCLUSIONS: Cartilage-forming benign bone tumors are rather prone to undergo malignant transformation. Although malignant transformation of a benign bone tumor is a rarely encountered situation, orthopedic surgeons should be cautious while following patients with a benign bone neoplasm. Early recognition and appropriate surgical treatment are required to achieve successful outcomes. The rate of local recurrence in secondary chondrosarcomas depends not only on adequate surgical treatment but also on the localization and histological grade.


Subject(s)
Bone Neoplasms/pathology , Cartilage/pathology , Chondrosarcoma/secondary , Neoplasms, Second Primary/pathology , Osteochondroma/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/surgery , Cartilage/diagnostic imaging , Cell Transformation, Neoplastic/pathology , Chondrosarcoma/diagnostic imaging , Chondrosarcoma/surgery , Female , Humans , Male , Middle Aged , Neoplasm Recurrence, Local , Neoplasms, Second Primary/diagnostic imaging , Neoplasms, Second Primary/surgery , Osteochondroma/diagnostic imaging , Osteochondroma/surgery , Radiography , Retrospective Studies
10.
Acta Cytol ; 51(4): 610-5, 2007.
Article in English | MEDLINE | ID: mdl-17718136

ABSTRACT

BACKGROUND: The hepatoid variant of yolk sac tumor (H-YST) is an exceedingly rare and highly malignant neoplasm. We present and discuss our experience with cytologic and histopathologic features of a mediastinal H-YST presenting with sternum metastasis, which to the best of our knowledge has not been previously reported. CASE: A 38-year-old man presented with a large mass on the sternum. Computed tomography of the thorax showed a large anterior mediastinal mass with sternum metastsis and multiple lung metastases. Laboratory examination revealed elevated serum alpha-fetoprotein (60,000 IU/mL). No tumor was found in the other organ systems. A percutaneous fine needle aspiration biopsy and subsequent open surgical biopsy were performed on the sternum metastasis. Cytologically, the tumor was composed of monotonous, large, round to polygonal hepatoid cells forming solid sheets and trabeculae entrapped with endothelial cells resembling hepatocellular carcinoma. Histopathologic sections of tumor showed tumor cells with eosinophilic to clear cytoplasm arranged in a solid, trabecular growth pattern, with some acinar formations. Immunohistochemical study supported the hepatoid origin. CONCLUSION: Fine needle aspiration cytology, together with the characteristic clinical presentations and specific tumor markers, is crucial to the initial diagnosis of H-YST.


Subject(s)
Endodermal Sinus Tumor/pathology , Mediastinal Neoplasms/pathology , Sternum/pathology , Adult , Antibodies , Biopsy, Fine-Needle , Endothelial Cells/pathology , Humans , Immunohistochemistry , Male , Middle Aged , Neoplasm Metastasis , alpha-Fetoproteins/metabolism
11.
J Orthop Sci ; 12(4): 334-40, 2007 Jul.
Article in English | MEDLINE | ID: mdl-17657552

ABSTRACT

BACKGROUND: This study retrospectively reviewed 28 patients who presented with chondroblastoma in our hospital during the period March 1986 to February 2006. We investigated factors associated with local recurrence of the tumors after surgery. METHODS: We recorded the patients' sex and age, the location of the pathology, imaging studies (status of growth plate and activity of lesions), histological findings, and treatment outcomes. RESULTS: Pain was the presenting symptom in all patients. The tumors were generally located in the epiphyses or apophyses of long bones, especially in the proximal humerus (9 patients), proximal tibia (7 patients), and proximal femur (5 patients). Our preferred treatment method was generally aggressive curettage of the lesion followed by bone grafting. There was local recurrence in six patients. A secondary aneurysmal bone cyst was present in two patients. CONCLUSION: Aggressive curettage and bone grafting resulted in local control in most patients. Tumor recurrence was not statistically associated with age, sex, growth plate status, tumor location, or tumor activity. The only parameter associated with increased local recurrence was previous surgery for chondroblastoma in the same location.


Subject(s)
Bone Neoplasms/surgery , Bone Transplantation , Chondroblastoma/surgery , Adolescent , Adult , Bone Neoplasms/physiopathology , Child , Chondroblastoma/physiopathology , Curettage , Female , Follow-Up Studies , Humans , Male , Neoplasm Recurrence, Local , Recovery of Function , Retrospective Studies
12.
Acta Orthop Traumatol Turc ; 41(1): 31-5, 2007.
Article in Turkish | MEDLINE | ID: mdl-17483633

ABSTRACT

OBJECTIVES: We evaluated surgical treatment of patients with chondromyxoid fibroma. METHODS: The study included 11 patients (6 females, 5 males; mean age 31 years; range 8 to 53 years) who underwent surgical treatment for chondromyxoid fibroma. The most common site of involvement was the tibia in three patients. Diagnosis was made preoperatively by tru-cut biopsies in seven patients and all the diagnoses were confirmed postoperatively by histopathologic examination. In addition to plain radiographs, computed tomography was used in 10 patients, and magnetic resonance was used in six patients. Surgery included wide resection, marginal excision or intralesional curettage followed by autologous bone graft or bone cement. The mean follow-up was 62.8 months (range 2 to 162 months). RESULTS: The main presenting symptom was pain in all the patients. Two patients with thoracic wall and tibia involvement, respectively, complained of a mass. Radiologic imaging showed soft tissue involvement in two patients. Recurrence occurred in three patients (27.3%), in whom initial surgical procedures were curettage alone (n=2) or with iliac graft (n=1). One patient with involvement in the phalanx of the thumb presented with pain 46 months after the second operation. A tru-cut biopsy yielded a diagnosis of secondary chondrosarcoma for which ray amputation was performed. No wound site infections or functional loss developed after surgical treatment. CONCLUSION: Chondromyxoid fibroma may develop in various bones of the body and occur at a wide age range. Curettage with autologous bone graft is an effective surgical method.


Subject(s)
Bone Neoplasms/surgery , Chondrosarcoma/surgery , Tibia , Adolescent , Adult , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/pathology , Bone Transplantation , Child , Chondrosarcoma/diagnostic imaging , Chondrosarcoma/pathology , Curettage , Female , Humans , Male , Middle Aged , Radiography , Treatment Outcome
13.
Surg Today ; 37(6): 486-8, 2007.
Article in English | MEDLINE | ID: mdl-17522766

ABSTRACT

Intrathoracic ectopic goiters are rare. To our knowledge, only two reports of thyroid tissue on the aorta have been reported in the English literature. A 42-year-old woman was found to have a right paracardiac mass. Sternotomy revealed a firm and encapsulated tumor attached to the anterolateral surface of the ascending aorta and a defect in the right superior part of the pericardium. The mass was completely excised and histopathologic examination confirmed a multinodular goiter. We discuss the features of this rare tumor.


Subject(s)
Cardiovascular Diseases/diagnosis , Choristoma/diagnosis , Thyroid Gland , Adult , Aorta , Cardiovascular Diseases/surgery , Choristoma/surgery , Female , Humans , Pericardium
14.
Acta Orthop Belg ; 73(1): 96-101, 2007 Feb.
Article in English | MEDLINE | ID: mdl-17441665

ABSTRACT

A consensus on the clinical course of fibrous dysplasia has not yet emerged in the literature. We retrospectively evaluated 36 patients who were diagnosed with fibrous dysplasia in our institution and were followed for a mean duration of 56.5 months (range 7-210 months). Their mean age was 25.8 years (range 5-67 years); 46.7% were male. The most frequent presenting complaints were pain (66% of patients) and pathological fracture (20%). Osteosarcoma developed in one patient 20 years after he had undergone radiation therapy for fibrous dysplasia in the tibia. Mazabraud syndrome was encountered in two patients, and aneurysmal bone cyst associated with fibrous dysplasia was seen in one patient. Fibrous dysplasia is generally considered a static disease, but with long-term follow-up it is found to have a more dynamic nature. For this reason, patients with fibrous dysplasia should be followed carefully over the long-term.


Subject(s)
Fibrous Dysplasia of Bone/surgery , Adolescent , Adult , Aged , Bone Cements/therapeutic use , Bone Cysts, Aneurysmal/etiology , Bone Neoplasms/etiology , Bone Transplantation , Child , Child, Preschool , Curettage , Female , Fibrous Dysplasia of Bone/complications , Fibrous Dysplasia of Bone/radiotherapy , Follow-Up Studies , Fractures, Spontaneous/etiology , Humans , Male , Middle Aged , Myxoma/pathology , Neoplasms, Radiation-Induced/etiology , Osteosarcoma/etiology , Retrospective Studies , Soft Tissue Neoplasms/pathology , Syndrome
17.
Acta Haematol ; 116(3): 198-202, 2006.
Article in English | MEDLINE | ID: mdl-17016039

ABSTRACT

A 42-year-old woman was diagnosed with myelodysplastic syndrome with fibrosis that developed bilaterally, cervical lymphadenopathy and cutaneous infiltration by trilineage extramedullary hematopoiesis after granulocyte colony-stimulating factor therapy because of severe neutropenia. Hepatosplenomegaly was not observed during her follow-up. Extramedullary hematopoiesis disappeared after growth factor therapy was stopped. Although the neutropenia was alleviated by growth factor administration, the appearance of an unusual involvement of extramedullary hematopoiesis should be kept in mind.


Subject(s)
Fibrosis/drug therapy , Granulocyte Colony-Stimulating Factor/adverse effects , Hematopoiesis, Extramedullary/drug effects , Myelodysplastic Syndromes/drug therapy , Adult , Face/pathology , Female , Humans
18.
Int J Dermatol ; 45(7): 814-8, 2006 Jul.
Article in English | MEDLINE | ID: mdl-16863517

ABSTRACT

BACKGROUND: Although papulopustular lesions are one of the diagnostic criteria for Behçet's disease, controversy exists as to the nature of these lesions. Specific vessel-based papulopustular lesions as well as nonspecific follicular lesions may be seen in patients with Behçet's disease. Some authors suggest that papulopustular lesions should be considered a positive criterion only if they exhibit a vessel-based neutrophilic reaction. OBJECTIVE: [corrected] To determine whether specific vessel-based papulopustular lesions can be differentiated clinically from nonspecific follicular lesions in patients with Behçet's disease. METHODS: Twenty-three papulopustular lesions in 20 patients with Behçet's disease were initially examined clinically by two dermatologists blind to each other's diagnosis. Biopsies taken from these lesions were examined by a pathologist unaware of the patient data. RESULTS: Leukocytoclastic vasculitis or perivascular infiltration was observed in 10 lesions, perifollicular and perivascular infiltration was noted in nine lesions, and perifollicular inflammation was seen in four biopsy specimens. Most of the lesions interpreted clinically as specific papulopustular lesions of Behçet's disease had predominantly perivascular infiltration or leukocytoclastic vasculitis; however, three papulopustular lesions evaluated by both observers as specific papulopustular lesions had only perifollicular inflammation, and one lesion diagnosed clinically as a nonspecific follicular eruption revealed perivascular neutrophilic reaction. Interobserver variance was noted in three papulopustular lesions. CONCLUSIONS: Clinical examination may not be sufficient to predict the dermatopathologic pattern in all lesions. Papulopustular lesions with no specific clinical and histopathologic features may create problems in the diagnosis of Behçet's disease.


Subject(s)
Behcet Syndrome/pathology , Skin Diseases, Papulosquamous/pathology , Skin/pathology , Adult , Biopsy, Needle , Diagnosis, Differential , Female , Hair Follicle , Humans , Male , Middle Aged , Predictive Value of Tests
19.
Acta Cytol ; 50(2): 225-30, 2006.
Article in English | MEDLINE | ID: mdl-16610696

ABSTRACT

BACKGROUND: Pituitary carcinomas are extremely rare tumors of the adenohypophysis. The presence of craniospinal and/or systemic extracranial metastases is the only reliable criterion for the diagnosis of pituitary carcinoma. To date, only 2 cases have been reported correctly by fine needle aspiration biopsy (FNAB). We present an additional case of pituitary carcinoma with FNAB features. CASE: A 60-year-old woman presented with clinical features of Cushing's disease and a pituitary tumor. She underwent transsphenoidal resection of the tumor. The initial diagnosis was an adrenocorticotrophic hormone (ACTH)-producing invasive pituitary adenoma. The patient presented again with neck pain 6 years after the operation. Magnetic resonance imaging revealed metastatic tumor masses at the level of C5-C6 of the cervical vertebrae. Intraoperative fine needle aspiration and incomplete excision of metastatic tumors were performed. Cytologically, tumor cells were composed of a combination of loose groups and single cells. Neoplastic cells had a relatively monotonous appearance and displayed characteristic neuroendocrine tumor features. Immunocytochemistry from cell block sections revealed AE1/ AE3, synaptophysin chromogranin A and ACTH positivity in the tumor cells. CONCLUSION: Pituitary carcinoma with extracranial systemic metastases demonstrates typical neuroendocrine features on fine needle aspiration. In the differential diagnosis, metastatic neuroendocrine carcinomas should be kept in mind. In the absence of sufficient clinical data, these 2 entities cannot be distinguished correctly through the cytologic features.


Subject(s)
Bone Neoplasms/secondary , Carcinoma/pathology , Cervical Vertebrae/pathology , Pituitary Neoplasms/pathology , Biopsy, Fine-Needle/methods , Bone Neoplasms/radiotherapy , Bone Neoplasms/surgery , Carcinoma/complications , Carcinoma/radiotherapy , Carcinoma, Neuroendocrine/diagnosis , Cervical Vertebrae/surgery , Female , Humans , Magnetic Resonance Imaging , Middle Aged , Neoplasm, Residual , Pituitary ACTH Hypersecretion/etiology , Pituitary Neoplasms/complications , Pituitary Neoplasms/radiotherapy , Sensitivity and Specificity
20.
J Infect ; 53(4): e171-3, 2006 Oct.
Article in English | MEDLINE | ID: mdl-16442163

ABSTRACT

Kikuchi Fujimoto disease (KFD) is a rare histiocytic necrotizing lymphadenitis which has a benign self-limiting clinical course. Its origin is unknown, but an abnormal autoimmune reaction has been suggested and infection is often considered to be an inciting agent. A 50-year-old man presented with fever, malaise, fatigue and sweat of 7 days duration, and diarrhea for 2 days. Physical examination revealed five mobile and painless cervical adenopathies. Entamoeba histolytica trophozoites and cysts were detected by microscopy of feces. Parenteral ornidazole treatment was commenced. Thorax computerized tomography showed lymph node sizes congruent with infection in the mediastinum, right hilus and right axillary region. Axillary lymph node biopsy and immunohistochemical analyses were then performed, and the results were consistent with histiocytic necrotizing lymphadenitis. From day 4 of antibiotic treatment the patient's body temperature decreased and reached a normal level on day 10. After discharge the patient returned for follow-up twice and was asymptomatic; his lymph nodes were either unpalpable or were decreased in size. We could not find any previous study or case report about a probable role for E. histolytica. Amebiasis can be a triggering factor in KFD or alternatively it is possible that its occurrence is coincidental.


Subject(s)
Entamoeba histolytica , Entamoebiasis/complications , Histiocytic Necrotizing Lymphadenitis/diagnosis , Histiocytic Necrotizing Lymphadenitis/parasitology , Animals , Histiocytic Necrotizing Lymphadenitis/pathology , Humans , Lymph Nodes/pathology , Male , Middle Aged
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