[Changes in the immunity indices of children suffering from inflammatory lung diseases undergoing cold exposures]. / Izmenenie pokazatelei immuniteta u detei, stradaiushchikh vospalitel'nymi zabolevaniiami legkikh, pri kholodovykh vozdeistviiakh.

Cooling and heating the feet in children with pulmonary inflammatory diseases in remission improved immunity. Air baths in addition to stimulating immunity enhanced bactericidal potential of blood neutrophils. Cool and warm showers decreased this potential.

[Immunoregulatory activity of the lungs in relation to corpuscular and soluble antigens]. / Immunoreguliatornaia aktivnost' legkikh v otnoshenii korpuskuliarnykh i rastvorimykh antigenov.

The immunoregulatory activity of the lungs in normal Wistar rats has been evaluated by difference between primary and secondary immune response to the same dose of the antigen introduced into the respiratory tract or intravenously. As shown in this investigation, intratracheal immunization with corpuscular antigens is accompanied by faintly pronounced antibody formation and a high degree of delayed hypersensitivity, while the introduction of soluble antigens into the respiratory tract leads to the active production of antibodies. The immunoregulatory activity of the lungs is T-dependent. The preliminary introduction of corpuscular or soluble antigen into the respiratory tract is accompanied by the formation of the local mechanism in the lungs for suppressing immune response to the subsequent intratracheal immunization.

[Volatile fractions of essential oil-based phytoncides as a component of therapeutic-rehabilitative complexes in chronic bronchitis]. / Letuchie fraktsii fitontsidov na osnove éfirnykh masel v sostave lechebno-reabilitatsionnykh kompleksov pri khronicheskikh bronkhitakh.

Three samples of essential oil (EO) were studied. Experiments on the cultures of human fetal lung fibroblasts showed 2 samples of EO in concentrations of 0.25-2.5 micrograms/ml to considerably stimulate DNA synthesis. Spray administration of one of the samples to guinea-pigs in line with egg powder sensitization for two more days resulted in a complete discontinuation of the respiratory allergic reaction to inhalation of a resolving dose of the antigen 12 days after sensitization. The evaluation of 96 patients with chronic bronchitis (mainly obstructive) subjected to daily 40-minute stay in the atmosphere containing natural concentrations (about 0.1 mg/m3) of EO volatile fractions, showed a significant increase in the permeability of the respiratory tracts (Tiffeneau's index) and a decrease in IgE total serum level.

[Various problems in the diagnosis and treatment of the broncho-obstructive syndrome]. / O nekotorykh voprosakh diagnostiki i lecheniia bronkhoobstruktivnogo sindroma.

Clinico-x-ray-laboratory investigation, bronchoscopy were performed, respiratory function and ECG were studied in 212 patients with different forms of chronic bronchitis. Six groups of patients were defined with relation to the presence or absence of obstruction, its nature (permanent, transient), prevalence (small, medium and large bronchi), genesis of disease (inflammatory, allergic). The characteristics of the groups and their clinico-x-ray, functional and immunological features were presented. Treatment including methods of climatotherapy, exercise therapy, pharmacological agents (antibacterial, broncholithic and antihistaminic), physiotherapy and administered with relation to the defined groups, proved to be effective. The improvement of bronchial permeability was noted in 49.5% (ranging from 40.0 to 68.7% in different groups).

[Immunological status and the condition of local defense factors in patients with various forms of chronic bronchitis treated by using performed physical factors]. / Immunnyi status i sostoianie mestnykh faktorov zashchity u bol'nykh s razlichnymi formami khronicheskogo bronkhita, lechennykh s ispol'zovaniem performirovannykh fizicheskikh faktorov.

Physiotherapeutic and other methods were employed for the treatment of patients with chronic nonobstructive bronchitis (CNB), chronic bronchitis with transient obstruction of the small bronchi of inflammatory genesis, chronic asthmatic bronchitis (CAB) and chronic obstructive bronchitis (COB). The level of secretory IgA and relative E-RFC number in the bronchial wash off, lysozyme concentration, the level of IgA and titer of heterophilic normal antibodies in the saliva were assessed. The content of T- and B-lymphocytes in the blood was studied. The results were assessed with a method of discrete-dynamic analysis. It was established that the incorporation of inductothermia with ethonium-electrophoresis and the magnetic field effect on the thyroid in CAB and inductothermia with ethonium-electrophoresis in COB in the complex of therapeutic measures produced a positive effect. In CNB (inactive phase) and COB patients inductothermia resulted in restoration of some interrelationships in the immune system whereas in CAB patients in their dysbalance. Different changes in the levels of interrelationships of certain parameters of the immune system were observed in the incorporation of sinusoidal modulated currents in the therapeutic complexes.

[Changes in the peripheral blood lymphocytes after immunization and its effect on the course of experimental inflammatory process in the lungs]. / Izmeneniia leikotsitov perifericeskoi krovi pri immunizatsii i ee vliianie na techenie eksperimental'nogo vospalitel'nogo protsessa v legkikh.

It was shown that in the immunization of rabbits with sorbed staphylococcus toxoid and human albumin, at the height of the immune response there occurred an intensification of biosynthesis and destabilization of lysosomal membranes of blood leukocytes, with a simultaneous development of microcirculation disturbances in the lungs. Development of pneumonia against the background of immunization led to a greater destabilization of the lysosomic membranes of leukocytes and to the intensification in the lungs of infiltrative and destructive processes, in comparison with the course of inflammation in the nonimmunized animals. Peculiarities of the antigens used caused some specificity in the course of pneumonia. A relationship between the changes of blood leukocytes and disturbances in the lungs in immunization is supposed.