Acquired factor VII deficiency in pediatric inflammatory bowel disease: Report of three cases.

Bleeding disorders can exacerbate gastrointestinal bleeding in inflammatory bowel disease (IBD) at the time of diagnosis or flares. Factor VII (FVII) deficiency is a life-threatening rare congenital bleeding disorder in childhood. This study describes three adolescent patients with IBD accompanied by acquired FVII deficiency. This is the first case series of patients with IBD accompanied by FVII deficiency. We hypothesized that inflammation, accelerated consumption, disease severity, and weight loss can cause decreased FVII activity in patients diagnosed with IBD. To control intestinal bleeding, we must keep in mind factor deficiencies in IBD.

Internet Addiction in Constipated Adolescents.

BACKGROUND: This study aims to assess internet addiction among adolescents with functional constipation and its relationship with sociodemographic and family factors. METHODS: In this case-control study, 57 and 35 adolescents with and without functional constipation, respectively, were recruited. Functional constipation was diagnosed by applying the Rome IV criteria. Previously validated Young's Internet Addiction Test-Short Form and Parent-Child Internet Addiction Test were completed, and sociodemographic data forms were filled out by all participants. RESULTS: According to the Parent-Child Internet Addiction Test questionnaire, 8.8% (n = 5) of the adolescents with FC suffered from internet addiction, whereas none of the healthy adolescents had internet addiction. The Young's Internet Addiction Test-Short Form survey reported internet addiction among 19.3% (n = 11) of the constipated adolescents and 17.1% (n = 6) of the healthy peers. The ratio of adolescents with limited symptoms and internet addiction in the functional constipation group was as high as 40.4%, according to Young's Internet Addiction Test-Short Form, and adolescents with functional constipation accompanied by pathological and problematic internet use was 24.6%, according to Parent-Child Internet Addiction Test. Although there was no significant difference in the internet addiction ratio between functional constipation and controls, our findings indicated that adolescents with functional constipation were suffering from high internet addiction rates. CONCLUSION: The evaluation of Young's Internet Addiction Test-Short Form and Parent-Child Internet Addiction Test surveys showed high internet usage problems, 40.4% and 24.6% in adolescents with functional constipation. According to adolescents' self-assessment, the internet addiction rate is higher but not significantly higher than their healthy peers. Therefore, internet addiction should be considered while treating adolescents with functional constipation, and clinicians should consider the opinions of adolescents besides their parents.

The Assessment of the Quality of Life in Children with Chronic Liver Disease.

BACKGROUND: Improvement in the quality of life (QoL) of patients with chronic diseases is as important as medical care. This study aimed to evaluate the QoL of children with chronic liver diseases and to determine related factors. METHODS: For this study, 101 children with chronic liver disease, 100 healthy controls, and their parents were included. The Pediatric Quality of Life Scale (PedsQL) was used to evaluate health-related QoL; higher scores indicate better QoL. Patients were evaluated before and after initiation of treatment and being educated about their illness. RESULTS: The mean patient age was 12.9 ± 3.9 years. Total PedsQL scores of the patients and the healthy control group were 38.6 ± 18.9 and 55.4 ± 14.3, respectively (P = .01). The scores of the parents of the patient and control groups were 35.4 ± 14.2 and 54.0 ± 16.9, respectively (P = .02). Patient and parent scores were positively correlated. Significantly higher scores were found in the 5-10 age group compared to the 10-15 and 15-18 age groups in the psychosocial score category. An increase in the QoL scores of patients who were started on medication other than steroid treatment was observed in the sixth month of treatment (35.8 ± 13.4 vs. 33.6 ± 8.9, P = .01, respectively). CONCLUSION: Both children with chronic liver diseases and their parents have a perceived lower QoL than healthy peers. The effect of chronic liver disease on psychosocial health is more pronounced in children older than 10 years. The quality of life is inversely proportional to the severity of the disease. It was observed that primary or symptomatic treatments have a positive impact on the perception of QoL, with the exception of steroid treatment.