ABSTRACT
We recently observed a near fatal case of transfusion-transmitted infection with standard platelet concentrate. Streptococcus dysgalactiae subspecies equisimilis was isolated both from donor, residual component container and cultures of the patient's blood. This should question the usefulness of systematic bacterial detection in platelet concentrates, however a lethal accident has occurred recently which escaped bacterial detection. This observation calls for implementation of pathogen inactivation procedures for platelets concentrates.
Subject(s)
Bacteremia/transmission , Platelet Transfusion/adverse effects , Shock, Septic/etiology , Streptococcal Infections/transmission , Streptococcus/isolation & purification , Bacteremia/diagnosis , Bacteremia/microbiology , Bacterial Typing Techniques , Blood Donors , Equipment Contamination , Female , Humans , Leukemia, Myeloid, Acute/complications , Mass Screening , Middle Aged , Pharynx/microbiology , Platelet Transfusion/instrumentation , Shock, Septic/microbiology , Species Specificity , Streptococcal Infections/diagnosis , Thrombocytopenia/etiology , Thrombocytopenia/therapySubject(s)
Blood Transfusion , Myelodysplastic Syndromes/therapy , Resuscitation , Sepsis/therapy , Sepsis/transmission , Streptococcal Infections/therapy , Streptococcal Infections/transmission , Streptococcus , Female , Humans , Middle Aged , Myelodysplastic Syndromes/blood , Myelodysplastic Syndromes/microbiology , Sepsis/blood , Streptococcal Infections/bloodABSTRACT
As antibiotic pressure often triggers bacterial resistance, the use of short-duration therapies is increasingly recommended. The objective of the present study was to evaluate both the clinical efficiency and the impact on oral streptococci of a 3 day versus a 7 day amoxicillin therapy for odontogenic infection requiring tooth extraction. On day 0, patients were randomly assigned to a 3 day or 7 day amoxicillin treatment. The tooth was extracted on day 2 and the post-operative follow-up was carried out on day 9. Oral flora was collected on days 0, 9 and 30, and the susceptibility of the streptococci to amoxicillin was determined. The results showed that treatment with amoxicillin for 3 or 7 days had a similar clinical efficiency, and also induced similar selection of oral streptococci with reduced susceptibility to amoxicillin, suggesting that the selection of strains with reduced susceptibility to amoxicillin is a rapid phenomenon, appearing even with short-duration therapies.