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1.
PLoS One ; 13(11): e0208257, 2018.
Article in English | MEDLINE | ID: mdl-30496321

ABSTRACT

Self-absorption describes a pathological tendency towards the internal mental world (internalization) that often conflicts with the accurate monitoring of the external world. In performance monitoring, an augmented electrophysiological response evoked by internal signals in patients with anxiety or depressive disorder seems to reflect this tendency. Specifically, the error-related negativity (Ne/ERN), an index of error processing based on internal signals, is larger in patients compared to controls. In the present experiment, we investigated whether the preferential processing of internal signals in patients is linked to diminished and inflexible external signal processing. To this end, the electrophysiological response evoked by external signals was analysed in patients with panic disorder and healthy controls. Participants performed a choice-response task, where informative or uninformative feedback followed each response, and a passive viewing task. As a replication of previous studies, patients presented an augmented Ne/ERN, indexing enhanced processing of internal signals related to errors. Furthermore, the vertex positive potential (VPP) evoked by visual stimuli was larger in patients than in controls, suggesting enhanced attention to external signals. Moreover, patients and controls showed similar sensitivity to the feedback information content, indicating a normal flexibility in the allocation of monitoring resources to external signals depending on how informative these signals are for performance monitoring. These results suggest that the tendency towards internal signals in patients with panic disorder does not hinder the flexible processing of external signals. On the contrary, external signals seem to attract enhanced processing in patients compared to controls.


Subject(s)
Evoked Potentials , Panic Disorder/physiopathology , Adult , Attention , Brain/physiopathology , Electroencephalography , Female , Humans , Male , Middle Aged , Photic Stimulation , Psychomotor Performance , Reaction Time , Signal Processing, Computer-Assisted , Young Adult
2.
Psychother Psychosom Med Psychol ; 66(3-4): 144-54, 2016 Mar.
Article in German | MEDLINE | ID: mdl-27035444

ABSTRACT

OBJECTIVES: The "Munich Attachment and Effectiveness Study" is a prospective psychotherapy study examining process and outcome of psychoanalytic psychotherapies. The study design and results are exemplified in a single case. METHODS: At 6 points in time audio-taped and transcribed therapy sessions are evaluated using process instruments (e. g. Psychotherapy Process Q-Set PQS) and interviews (e. g. Operationalized Psychodynamic Diagnostics OPD, Heidelberg Structural Change Scale HSCS, Adult Attachment Interview AAI). RESULTS: In the single case, findings from the psychotherapeutic process (e. g. "therapist is empathic" according to PQS) complement the achieved changes. 5 HSCS problem foci reached level of "restructuring", on the Reflective Functioning Scale a marked change of RF took place and the attachment classification changed over time. CONCLUSIONS: The instruments employed in this study corresponded well in assessing change processes in spite of differing theoretical background.


Subject(s)
Neuropsychological Tests , Psychotherapy, Psychodynamic/methods , Adult , Female , Humans , Interview, Psychological , Male , Mental Disorders/therapy , Middle Aged , Prospective Studies , Psychiatric Status Rating Scales , Treatment Outcome , Young Adult
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