It's Not Only What You Say, But Also How You Say It: Machine Learning Approach to Estimate Trust from Conversation.

OBJECTIVE: The objective of this study was to estimate trust from conversations using both lexical and acoustic data. BACKGROUND: As NASA moves to long-duration space exploration operations, the increasing need for cooperation between humans and virtual agents requires real-time trust estimation by virtual agents. Measuring trust through conversation is a novel and unintrusive approach. METHOD: A 2 (reliability) × 2 (cycles) × 3 (events) within-subject study with habitat system maintenance was designed to elicit various levels of trust in a conversational agent. Participants had trust-related conversations with the conversational agent at the end of each decision-making task. To estimate trust, subjective trust ratings were predicted using machine learning models trained on three types of conversational features (i.e., lexical, acoustic, and combined). After training, model explanation was performed using variable importance and partial dependence plots. RESULTS: Results showed that a random forest algorithm, trained using the combined lexical and acoustic features, predicted trust in the conversational agent most accurately (Radj2=0.71). The most important predictors were a combination of lexical and acoustic cues: average sentiment considering valence shifters, the mean of formants, and Mel-frequency cepstral coefficients (MFCC). These conversational features were identified as partial mediators predicting people's trust. CONCLUSION: Precise trust estimation from conversation requires lexical cues and acoustic cues. APPLICATION: These results showed the possibility of using conversational data to measure trust, and potentially other dynamic mental states, unobtrusively and dynamically.

The miR-181 family regulates colonic inflammation through its activity in the intestinal epithelium.

The intestinal epithelium is a key physical interface that integrates dietary and microbial signals to regulate nutrient uptake and mucosal immune cell function. The transcriptional programs that regulate intestinal epithelial cell (IEC) quiescence, proliferation, and differentiation have been well characterized. However, how gene expression networks critical for IECs are posttranscriptionally regulated during homeostasis or inflammatory disease remains poorly understood. Herein, we show that a conserved family of microRNAs, miR-181, is significantly downregulated in IECs from patients with inflammatory bowel disease and mice with chemical-induced colitis. Strikingly, we showed that miR-181 expression within IECs, but not the hematopoietic system, is required for protection against severe colonic inflammation in response to epithelial injury in mice. Mechanistically, we showed that miR-181 expression increases the proliferative capacity of IECs, likely through the regulation of Wnt signaling, independently of the gut microbiota composition. As epithelial reconstitution is crucial to restore intestinal homeostasis after injury, the miR-181 family represents a potential therapeutic target against severe intestinal inflammation.