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Org Biomol Chem
; 14(37): 8670-3, 2016 Oct 07.
Article
in English
| MEDLINE
| ID: mdl-27604065
ABSTRACT
A series of bicyclic isourea derivatives were prepared from 1-deoxynojirimycin using a concise synthetic protocol proceeding via a guanidino intermediate. Inhibition assays with a panel of glycosidases revealed that these deoxynojirimycin-derived bicyclic isoureas display very potent inhibition against human recombinant ß-glucocerebrosidase with IC50 values in the low nanomolar range.