ABSTRACT
Although several hypotheses have been suggested regarding the accumulation of 99Tc(m)-sestamibi in tumours, the exact uptake mechanism is still a matter of discussion. We investigated ultrastructural cell type of thyroid tumours by electron microscopy (EM) and compared them with uptake of 99Tc(m)-sestamibi. Thyroid scintigraphy with 99Tc(m)-sestamibi was performed on 25 patients who displayed a cold nodule on previous pertechnetate scintigraphy. Tumour-to-thyroid (T/N) uptake ratio was measured semiquantitatively. Surgery was performed in all patients and cytological evaluations were done by EM. Histopathology revealed six papillary carcinomas, 16 follicular adenomas and three Hurthle cell tumours. Thyroid cells were classified as A and B cells using EM. The cytoplasm of an A cell has the normal amount of mitochondria, whereas cytoplasm of a B cell (mitochondria-rich oxyphilic cell) contains abundant mitochondria. The median T/N ratio on the early scan for an A-cell tumour was 1.21 (range, 0.74-3.2), late T/N ratio was 1.25 (range, 0.72-3.85). The T/N ratio for the B-cell tumours was 1.42 (range, 0.6-3.6) on the early scan and 1.18 (range, 0.64-5.58) on the late scan. There was no statistically significant difference between T/N ratios of A- and B-cell tumour groups. A significant difference was also not seen between early and late T/N ratios. According to our findings, 99Tc(m)-sestamibi accumulates in thyroid tumours with both A and B cells, therefore these results suggest that the mitochondrial content of tumours is not only responsible for sestamibi uptake and retention.
Subject(s)
Radiopharmaceuticals/pharmacokinetics , Technetium Tc 99m Sestamibi/pharmacokinetics , Thyroid Neoplasms/metabolism , Thyroid Neoplasms/pathology , Adenoma/pathology , Adult , Biopsy , Carcinoma, Papillary/pathology , Female , Humans , Male , Microscopy, Electron , Middle Aged , Thyroid Neoplasms/ultrastructureSubject(s)
Carcinoma, Bronchogenic/diagnostic imaging , Lung Neoplasms/diagnostic imaging , Lung/diagnostic imaging , Pulmonary Atelectasis/diagnostic imaging , Radiopharmaceuticals , Technetium Tc 99m Sestamibi , Aged , Carcinoma, Bronchogenic/complications , Female , Humans , Lung Neoplasms/complications , Male , Middle Aged , Pulmonary Atelectasis/etiology , Radionuclide Imaging , Tomography, X-Ray Computed , Tuberculosis, Pulmonary/complications , Tuberculosis, Pulmonary/diagnostic imagingABSTRACT
The ectopic development of teeth has been reported in many locations including the nasal cavity, maxillary sinus and the chin. Ectopic teeth may be permanent, deciduous or supernumerary. A case is presented in which a supernumerary tooth erupted into the maxillary sinus of an 11 year old boy.
Subject(s)
Maxillary Sinus/diagnostic imaging , Tooth Eruption, Ectopic/diagnostic imaging , Tooth, Supernumerary/diagnostic imaging , Child , Facial Pain/etiology , Follow-Up Studies , Humans , Male , Radiography, Panoramic , Rhinitis/etiologyABSTRACT
Amelogenesis imperfecta (AI) comprises a diverse group of hereditary enamel disorders that are characterized by hypoplastic and in some cases hypomineralized defects. Purpose of this investigation was to characterize the ultrastructure of autosomal recessive smooth hypoplastic amelogenesis imperfecta enamel. The primary teeth that exfoliated physiologically were studied by scanning electron microscopy. By using scanning electron microscope, multiple shallow depressions and deep tubular voids were observed. Irregular enamel, irregularities in enamel crystallites, hypoplastic areas on the enamel surface were seen.
