ABSTRACT
The authors defined major criteria for allergenic danger caused by work conditions. The criteria include sensibilizing activity, intensity of chemical allergen, routes of its intake, combinations and associations with other occupational hazards and, according to hygienic classification of work and to classification of chemical allergens, to importance in causing the allergic diseases, are assessed in points. Using the criteria, considering various associations of allergies and concomitant factors and their correspondence to occurrence and severity of immunologic and allergic disorders, clinical signs of allergies (including occupational), the authors specified integral scale for evaluation of allergenic danger caused by work conditions.
Subject(s)
Hypersensitivity/diagnosis , Occupational Diseases/diagnosis , HumansSubject(s)
Occupational Diseases/immunology , Adult , Allergens , Chemical Industry , Drug Hypersensitivity/diagnosis , Drug Hypersensitivity/etiology , Humans , Hypersensitivity/diagnosis , Immunohistochemistry , Male , Mass Screening , Occupational Diseases/chemically induced , Occupational Diseases/prevention & controlABSTRACT
Natural tall colophony and its modification by monoethanolamine are moderate allergens at intracutaneous and epicutaneous ways of sensibilization reproduction. In the conditions of 30-days inhalational exposure in concentrations on the level of Limch modified by monoethanolamine colophony does not cause sensitization; while the modified tall colophony induces a weakly expressed allergic effect in experimental guinea pigs--albinos.
