[Clinico-morphological features of chronic hepatopathy with concomitant viral infection and chronic narcotic intoxication].

The aim of this work was to evaluate liver function in subjects suffering from viral hepatitis and concomitant narcotic dependence. Clinico-biochemical, virologic, and morphological studies involving 92 patients revealed a number of specific features of chronic viral hepatitis complicated by drug addiction. However, the majority of them could be reliably identified only by a quantitative microscopic method. Worthy of special note are high frequency of lymphoid follicle formation in the portal tracts and signs of developing micronodular liver cirrhosis.

[Hepatopathies in concomitance of chronic drug and alcoholic intoxications].

Liver biopsy specimens were morphologically investigated in 87 patients, including 30 with drug (marijuana and poppy straw) addiction, 23 with chronic alcoholic intoxication, and 25 abused narcotics and alcohol concomitantly. All the patients were not found to be infected with viruses of hepatitis B, C, G, TTV, or CMN; the clinical manifestations and biochemical blood parameters were studied over time. In patients who simultaneously used drugs and alcohol, the specific features of hepathopathy were shown to be more pronounced and more rapidly progressive changes as fatty hepatosis and diffuse liver tissue fibrosis than in those used either drugs alone or alcohol alone. This is favored by chronic inflammation and cholestasis that is accompanied by bile duct proliferation. Concomitance of these processes leads to permanent liver tissue atrophy and death and to the relatively early development of hepatic monolobular cirrhosis. The mechanisms responsible for the patho- and morphogenesis of combined toxic hepatopathy are discussed.