[Perspectives of prevention and treatment of herpes symplex with regular recurrence].

AIM: To assess efficacy of two-stage treatment of severe genital herpes (GH) with regular recurrences: combined use of antivirus medicines with interferon preparations and its inductors followed by antirecurrence vaccine therapy. MATERIAL AND METHODS: Two-stage treatment was given to 100 patients suffering from GH with severe regular recurrences. One-stage treatment included famvir in combination with interferon (viferon) or interferon inductors (amixin, cycloferon) and antioxidants. Stage two treatment consisted of vaccine therapy of patients who failed prophylactic standard vaccination by allergometric technique. RESULTS: The first stage treatment prolonged recurrence-free period 2-3-fold in more than 85% patients, improved quality of life. Stage-two treatment resulted in long-term clinicoimmunological remission which is necessary for conduction of anti-recurrence vaccine treatment. CONCLUSION: Changes in therapeutic-preventive policy in patients with recurrent GH with regular recurrence (2 stage of treatment) prolong recurrence-free intervals, improve quality of life and social adaptation of patients.

[Inhibition of herpes simplex virus type 1 reproduction by probiotic bacteria in vitro].

Light and immunofluorescence microscopies were used to study the cytopathic effect of herpes simplex virus type 1 (HSV-1) grown on the Vero cell cultures in the absence or presence of supernatants of Enterococcus faecium L3, Lactobacillus plantarum 8A-P3, and Escherichia coil M17. The effect of the probiotic strains was evaluated estimating the proportion of changed cells and the infective dose of the virus. The supernatants of the cultures of Lactobacillus sp. and Enterococcus sp., unlike those of E. coil, have antiviral activity. Inhibited viral replication was more evident when the supernatants were added until the cultured HSV-1 cells were infective. An enterococcal supernatant and its obtained peptide extract showed the maximum antiviral activity. This strain may be associated with the production of bacteriocins and bacteriocin-like substances.

[Epidemiologic aspects of human herpes virus infection type VI]. / Epidemiologicheskie aspekty infektsii, sviazannoi s virusom gerpesa cheloveka 6-go tipa.

The paper presents a review of foreign publications (35 references) regarding the history of isolation and investigation of one of the herpesviruses--a new lymphotropic human herpesvirus type 6 (HHV-6). The wide spread of the virus in the human population is demonstrated. Both patients with manifestative types of the disease and asymptomatic HHV-6 carriers are supposed to provoke the infection. The disease can be transmitted by the droplet and genital routes of infection, via hemotransplantation, and by the vertical transmission of the agent. HH-6 was found to play an etiological role in the development of sudden exanthema in early childhood.

[Current approaches to the treatment of severe influenza]. / Sovremennye podkhody k lecheniiu tiazhelykh form grippa.

The complex pathogenetic therapy of severe (complicated) forms of influenza infection is proposed. The drugs with antioxidant, antiprotease or immunomodulating activities are used for the purpose. The clinical character of infection or stage of pathologic process are considered for appropriate drug application. The advantages of drugs with diversified mechanisms of action involved in the complex treatment of influenza are demonstrated.