[Evaluation of the immunological activity and safety of group B meningococcal vaccine prepared from a natural complex of specific polysaccharide and outer membrane proteins]. / Otsenka immunologicheskoi aktivnosti i bezopasnosti meningokokkovoi gruppy B vaktsiny iz prirodnogo kompleksa spetsificheskogo polisakharida i belkov naruzhnoi membrany.

Immunological activity and safety of group B meningococcal vaccine prepared from a natural complex of specific polysaccharide and outer membrane proteins were under study. The immunological safety of the vaccine was evaluated by the absence of antibodies to denaturated and native DNA (d-DNA and n-DNA). As shown with the use of the enzyme immunoassay (EIA), the administration of the vaccine did not induce antibody formation to d-DNA and n-DNA during the observation period. The titer of bactericidal antibodies in the immune bacteriolysis assay (IBA) to the vaccine strain B:2b:P1.2 after immunization increased four-fold and greater in 80% of the vaccinated persons. The significant increase of bactericidal antibodies to heterologous strains B:2a:P1.2 and B:15:P1.7 was registered in 20-30% of the vaccinees, respectively. A month after the repeated vaccination an increase in specific IgG antibodies to the complex antigen was found to occur according to EIA results. The use of RIB made it possible to evaluate the preventive activity of group B meningococcal vaccine as a whole and to suppose that the vaccine induced mainly type-specific response.

[Enterotoxic properties of salmonellae and their neurotoxins]. / Enterotoksicheskie svoistva sal'monell i kh neirotoksinov.

Most of live S. typhimurium cultures are capable of intraintestinal proliferation and possess enterotoxic activity. The capacity of S. typhimurium strains for producing enterotoxins is not connected with their origin. The parenteral immunization of rabbits with corpuscular vaccines prepared from S. typhimurium induced changes in the sensitivity of different sections of the small intestine of the animals to the enterotoxic action of live homologous cultures. Neurotoxin isolated from S. typhi was found to possess enterotoxic activity.

[Biological characteristics of Salmonella typhimurium obtained from different sources 1975-1980]. / Biologicheskie osobennosti Salmonella typhimurium, poluchennykh iz raznykh istochnikov v 1975-1980 gg.

Distinct differences in a number of biological properties between S. typhimurium hospital strains and cultures of animal origin have been revealed. During 1975-1980 changes in the fermentation of lysine were observed in hospital strains and the retarded fermentation of sorbitol was revealed in strains of animal origin. S. typhimurium 1R, a new highly virulent biovariant resistant to antibiotics, and enzymatic varieties of biovar 11S were isolated. The nonstability of enzymatic differences between hospital strains and cultures of animal origin necessitates their constant observation in order to differentiate these cultures for the purpose of epidemic analysis. Complete correlation between the properties of cultures circulating on a limited territory and the character of morbidity in Salmonella infection demonstrates the epidemiological importance of the intraspecific differentiation tests under study.

[Comparative evaluation of the immunological activity of new typhoid vaccines with established prophylactic effectiveness (data from a controlled experiment)]. / Sravnitel'naia otsenka immunologicheskoi aktivnosti novykh briushnotifoznykh vaktsin s ustanovlennoi profilakticheskoi éffektivnost'iu (dannye kontroliruemogo opyta)

The authors present the results of studying the immunological efficacy of a dry alcoholic typhoid vaccine enriched with S. typhi Vi-antigen in the assessment of this vaccine in controlled epidemiological trial during the immunization of children aged 7--8 years. O- and Vi-antibodies were tested in the reaction of hemagglutination, H-antibodies--in the agglutination reaction with the microbial diagnostic agent, the properties of antibodies--in a test with cystein, and bactericidal properties of the sera--against the virulent S. typhi strain. Examination of 355 coupled sera obtained before and 3 weeks after the immunization demonstrated a high level of Vi-(1:47) and of the O-(1:580) antibodies and high bactericidal properties of the sera in persons vaccinated with the alcoholic vaccine enriched with the S. typhi Vi-antigen. The results obtained and the data on the formation of prolonged immunity following a simgle immunization suggested that a high protective effect was caused by a combined action of the O- and Vi-antigens contained in the vaccine in optimal doses.