ABSTRACT
BACKGROUND: Gingival overgrowth with ulceration has recently been recorded in 4 reports: (1) our report of a British patient with ligneous conjunctivitis in whom the gingival lesions appeared to be related to tranexamic acid-an antifibrinolytic agent; (2) a report of 2 Turkish patients and an Italian patient with mainly gingival lesions; (3) our report of 5 Turkish patients with mainly gingival lesions; and (4) a report of 3 new Turkish cases, which also were associated with gingival lesions and alveolar bone loss. These patients all had gingival swellings, and a minority had conjunctival involvement similar to ligneous conjunctivitis, although the etiology was unclear in all. Nevertheless, fibrin exudation was fundamental because the hyaline or amyloidaceous material seen on the gingival biopsy stained for fibrin but failed to stain for amyloid. METHODS: We have examined 6 more patients who exhibited gingival swelling caused by amyloidaceous deposits that stained only for fibrin, and we assayed their plasminogen levels. RESULTS: The plasminogen functional activity assayed in these 6 additional patients, and in 2 of the 5 patients previously reported by us, was significantly reduced. CONCLUSIONS: Gingival overgrowth with ulceration appears to be a new complication caused by plasminogen deficiency; it also appears to be related to ligneous conjunctivitis in some cases.
Subject(s)
Gingival Diseases/etiology , Plasminogen/deficiency , Adolescent , Adult , Blood Protein Disorders/complications , Child , Conjunctivitis/etiology , Female , Gingival Overgrowth/etiology , Humans , Male , Oral Ulcer/etiology , Staining and LabelingABSTRACT
Multiple diffuse fibrosarcoma of bone is a very rare condition, with only 3 cases reported. Its presentation is like that of a multiple myeloma or a metastatic tumor, with multiple osteolytic lesions, and its extent is limited to the bones. Disseminated involvement of the vertebrae was detected in a 26-year-old man, suggesting a metastatic tumor; however, no primary organ or soft-tissue mass was identified. The histopathologic findings of the biopsy material were consistent with fibrosarcoma. Despite treatment, the patient died within 15 months.
Subject(s)
Bone Neoplasms/diagnosis , Fibrosarcoma/diagnosis , Adult , Biopsy , Fatal Outcome , Humans , Male , Spine/abnormalitiesABSTRACT
BACKGROUND: Hypertrophic osteoarthropathy (HOA), well known in adults, is rarely encountered in children. The clinical features include clubbing of the fingers and toes, arthritis, and painful periosteal new bone formation of the tubular bones. The association of malignant disorders with HOA is more common in adults than in children. CASE: In this paper, a 12-year-old boy with intrathoracic Hodgkin disease and HOA is presented and four other children with HOA and Hodgkin disease in the literature reviewed. DISCUSSION: The presence of HOA has been thought to be a bad prognostic sign, but complete remission of Hodgkin disease and regression of clinical signs and symptoms of HOA were attained in our patient after chemotherapy and radiotherapy, and continue during 9 months post-therapy follow-up. CONCLUSIONS: HOA accompanying a malignant tumor in children is very rare. Only 5 cases have been associated with Hodgkin disease, including the present boy. It is important that patients with symptoms of HOA and an intrathoracic mass be examined carefully to rule out a malignancy.
Subject(s)
Hodgkin Disease/complications , Mediastinal Neoplasms/complications , Osteoarthropathy, Secondary Hypertrophic/complications , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Child , Hodgkin Disease/diagnosis , Hodgkin Disease/drug therapy , Humans , Male , Mediastinal Neoplasms/diagnosis , Mediastinal Neoplasms/drug therapy , Osteoarthropathy, Secondary Hypertrophic/diagnosisABSTRACT
Gingival hyperplasia may be genetic, may be acquired as a consequence of exposure to drugs and other agents or may appear as part of a more widespread disorder. Five patients who acquired gingival hyperplasia due to amyloidaceous deposits staining only for fibrin are presented. This appears to be a new entity related to ligneous conjunctivitis.
Subject(s)
Amyloidosis/complications , Conjunctivitis/complications , Gingival Hyperplasia/complications , Adolescent , Adult , Amyloidosis/pathology , Child , Child, Preschool , Conjunctivitis/pathology , Female , Fibrin/analysis , Gingival Hyperplasia/pathology , Humans , MaleABSTRACT
A solitary plexiform neurofibroma localized on the vestibular side of the right mandible in a 37-year-old woman is described. The tumor was excised, and there was no recurrence after 2 years.
Subject(s)
Cranial Nerve Neoplasms/pathology , Mandibular Neoplasms/pathology , Mandibular Nerve/pathology , Neurofibroma, Plexiform/pathology , Adult , Female , HumansSubject(s)
Neoplasms, Germ Cell and Embryonal/pathology , Neoplasms, Germ Cell and Embryonal/secondary , Stomach Neoplasms/secondary , Testicular Neoplasms/pathology , Adolescent , Adrenal Gland Neoplasms/secondary , Brain Neoplasms/secondary , Humans , Liver Neoplasms/secondary , Lung Neoplasms/secondary , MaleABSTRACT
Reports on the incidence of odontogenic tumours are infrequent with only a limited number of series having appeared in the literature. In this paper, the results of a multicentre retrospective study on the histologic types and relative frequencies of odontogenic tumours in Turkey are presented. The results indicated that the most frequent histologic type was ameloblastoma (36.5 per cent) and the area at greatest risk for the development of odontogenic tumours was the mandibular molar region. A Table showing the most likely type of tumour by location is also presented.
Subject(s)
Jaw Neoplasms/epidemiology , Odontogenic Tumors/epidemiology , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Child , Child, Preschool , Female , Humans , Jaw Neoplasms/pathology , Male , Middle Aged , Odontogenic Tumors/pathology , Retrospective Studies , Sex Factors , Turkey/epidemiologySubject(s)
Gingival Neoplasms/pathology , Odontogenic Tumors/pathology , Epithelium/pathology , Fibroma/pathology , Humans , Male , Middle AgedABSTRACT
A case of frontotemporal intracerebral schwannoma in a 16-year-old girl with epilepsy and progressive hemiparesis of 3 years' duration is described. The histologic diagnosis and possible sites of origin are discussed. In addition, five previously reported cases of supratentorial intracerebral schwannoma are discussed. All of the patients reviewed presented with epilepsy early in life, and there was no association with neurofibromatosis.
