ABSTRACT
The present work deals with results of intensive therapy and temporary organ substitution by using hemoperfusion through a suspension of living donor hepatocytes in 71 patients with acute hepatic insufficiency. Hemoperfusion was performed through a suspension of fresh living hepatocytes or through a suspension of cryo-conserved (during 60 days) living hepatocytes. Lethality was 37-42%.
Subject(s)
Hemoperfusion/methods , Liver Failure, Acute/therapy , Liver/cytology , Animals , Cryopreservation , Evaluation Studies as Topic , Hemoperfusion/adverse effects , Humans , Remission Induction , Swine , Tissue PreservationSubject(s)
Disease Models, Animal , Hemoperfusion/methods , Sepsis/therapy , Spleen , Staphylococcal Infections/therapy , Surgical Wound Infection/therapy , Animals , Dogs , Humans , Male , Middle Aged , SuspensionsABSTRACT
The results of intensive therapy and temporary organ substitution by hemoperfusion through a suspension of active hepatocytes in 126 patients suffering from acute hepatic insufficiency (AHI) induced by virus B hepatitis, virus non-A, non-B hepatitis, acute toxic hepatitis, active liver cirrhosis, sepsis leptospirosis long-term subhepatic jaundice are presented in this paper. Hepatic encephalopathia confirmed both clinically and electroencephalographically was registered in all the patients. The patients were subdivided into two groups: a complex of commonly used curative measures according to the intensive therapy for AHI was applied in Group A (67 patients); in Group B (59 patients), alongside with the above measures, temporary organ substitution by hemoperfusion through a suspension of active porky hepatocytes was also performed. The lethality in Group A made up 59% and that in Group B was 37%.
