[Morphologic changes following experimental influenza virus infection and the therapeutic administration of flavonoids in aqueous extract]. / Modifications morphologiques consécutives à l'infection expérimentale à virus de la grippe et à l'administration thérapeutique de flavonoïdes en extrait aqueux.

Influenza virus strain A/PR8/34(H1N1) and flavonoid aqueous extract with therapeutical function were administered by intranasal route. Pathological examinations were done three and ten days after administration to evaluate the morphological modifications established in the lung parenchyma. Results showed that therapeutical administration of flavonoids had good effects on interstitial bronchopneumonia evolution till complete recovery. Flavonoid aqueous extract administered by intranasal route was well tolerated by the organism.

[The mechanism of the antiherpetic action of an aqueous propolis extract. II. The action of the lectins of an aqueous propolis extract]. / Mécanisme de l'action antiherpétique de l'extrait aqueux de propolis. II. Action des lectines de l'extrait aqueux de propolis.

The report brings proofs of the presence of a lectin in the water propolis extract. It was detected in human fibroblast extracts previously treated with the propolis extract. Presence of the lectin was confirmed by polyacrylamide gel electrophoresis in the presence of SDS.

[Mechanism of the anti-herpetic activity of aqueous extract of propolis. II. Activity of lectins from the aqueous extract of propolis]. / Mécanisme de l'action antiherpétique de l'extrait aqueux de propolis. II. Action des lectines de l'extrait aqueux de propolis.

The report brings proofs of the presence of a lectin in the water propolis extract. It was detected in human fibroblast extracts previously treated with the propolis extract. Presence of the lectin was confirmed by polyacrylamide gel electrophoresis in the presence of SDS.

[The mechanisms of the antiherpetic action of aqueous propolis extracts. I. The antioxidant action on human fibroblast cultures]. / Mécanismes de l'action antiherpétique de l'extrait aqueux de propolis. I. Action anti-oxydante sur cultures fibroblastes humains.

A redox state modulation model was worked out in human fibroblast cultures treated with oxidation stress inducing agents and a redox agent, virtually protecting cell against the stress. Quantification of the global redox changes in fibroblasts was done using the hemoglobin electronic spectrum, in the presence and in the absence of H2O2.

[The effects of aqueous extracts of Raphanus niger on an experimental influenza infection in mice and on the enzyme polymorphism in lung tissue extracts]. / Les effets d'un extrait aqueux de Raphanus niger sur l'infection expérimentale à virus de la grippe chez la souris et sur le polymorphisme de quelques enzymes dans les extraits de tissu pulmonaire.

Prophylactic effects of Raphanus niger water extract against A/PR 8/34 influenza virus experimental infection was tested in mice, by means of the following parameters: mortality mean survival time and hemagglutinating (HA) titre of lung extract. Variations of the isoenzymatic structures of peroxidase and acid and alkaline phosphatases were studied too. The results revealed the significant reduction of mortality and of hemagglutinating titre and the augmentation of mean survival time. Modifications of the isoenzymatic structures, especially of the phosphatases, are characteristic for the illness state as well as for the one induced by R. niger extract treatment.

[Research on antiviral chemotherapy at the Stefan S. Nicolau Institute of Virology in 1984-1989]. / Recherches de chimiothérapie antivirale à l'Institut de Virologie "Stefan S. Nicolau" dans l'intervalle 1984-1989.

The paper is a review of researches done at the "Stefan S. Nicolau" Institute of Virology, in Bucharest, the last five years, in the antiviral chemotherapy field, as well as of the chemotherapeutical implications of studies conducted about other aspects of virology.

[The action of a Chamenerion angustifolium extract in experimental influenza virus infection in mice]. / L'action d'un extrait de Chamenerion angustifolium sur l'infection expérimentale à virus de la grippe chez la souris.

V-2 and V-8, two preparations containing an extract from Chamenerion angustifolium, were tested in vitro and in vivo, for their anti-influenza properties. In vitro, the two preparations induced a significant reduction of the hemagglutinating titers. In vivo, administration of each of the two products, three times before the influenza virus inoculation significantly reduced (27%) the mortality rate and the hemagglutinating titers, and increased the survival mean time (SMT) (about 3.5 times). These effects were more striking when control infection was done seven days after the last administration of the extract: the mortality rate reduces by 50%, the HA titers lowered to zero and the SMT increased by about 5 times.

[Treatment of cutaneous herpes and herpes zoster with Nivcrisol-D]. / Traitement de l'herpès cutané et du zona zoster à l'aide de NIVCRISOL-D.

The results obtained at the Dermatological service of the Colentina Hospital show that the product NIVCRISOL-D, containing propolis, has a significant therapeutical effect against recurrent herpes and zona zoster.

[Immunomodulation with natural products. I. Effect of an aqueous extract of Raphanus sativus niger on experimental influenza infection in mice]. / Immunomodulation par des produits naturels. Note I. Effet d'un extrait aqueux de Raphanus sativus niger sur l'infection grippale expérimentale chez la souris.

A Raphanus sativus niger water extract was administered by intranasal instillations to mice before inoculation of the influenza virus A/PR 8/34 (H1N1) strain by the same route. The extract ensured some protection against the experimental influenza infection. A significant decrease of the hemagglutinin titre of the mouse lung homogenate was noted, as well as a decrease of the mortality rate and a significant increase of the rate of survival as compared to the untreated controls.

The action of mouse liver and lung homogenates on the ESR signal of a spin-labelled antiviral compound.

A spin-labelled derivative of amantadine was prepared and added to mouse liver and lung homogenates in vitro in the presence and in the absence of inhibitors of oxidative enzymes; the kinetics of the quenching of ESR signals was followed up in different experimental variants.