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Chem Commun (Camb)
; 51(57): 11390-3, 2015 Jul 21.
Article
in English
| MEDLINE
| ID: mdl-26085065
ABSTRACT
ß-Glucocerebrosidase deficiency leads to Gaucher disease and is a potential marker of Parkinson's disease. We have identified N-octyl conduritol aziridine as a potent and specific covalent inactivator of GBA1 in living cells. This compound is a promising lead towards a positron emission tomography probe intended to image GBA1 activity.