ABSTRACT
The efficiency of choosing antibiotics using two methods was analyzed. The first method is based on standard laboratory analysis including isolation of pure cultures of prospective agent and detection of their individual sensitivity to antibiotics. The second method is based on a new express-technique permitting to simultaneously evaluate effect of pharmaceuticals on cultivated and not cultivated yet bacteria without isolation of pure cultures. At that, the second method permits to determine efficiency of antibiotics namely in those concentrations that can be made in the given nidus of infection. The study demonstrated existence of discrepancy between results obtained by using the given methods. The cause of discrepancy can be presence of not cultivated yet bacteria in pathologic sample. In favor of this assumption testify the received data concerning samples from patients where were presented a significant number of spore-former bacteria having additional mechanisms of resistance to antibiotics. Furthermore, the implemented study established antibiotics characterized by the greatest discrepancy of results obtained by applied methods that indicates the necessity of revision of schemes of implementation of start or empiric therapy.
Subject(s)
Anti-Bacterial Agents/pharmacology , Bacteria , Humans , Prospective StudiesABSTRACT
In 1999-2000 the preventative vaccination against virus hepatitis A (HA) was performed in 62 thousands of people serving in the North-Caucasian Military District. We proceeded from the data that even the single injection could provide quick protection, at least for 1 year, in 95% of the cases. After the vaccination the steady distribution of HA incidence level by months among the servicemen and decrease in the incidence indices during the period under review (approximately in 3 times) comparing the previous period were observed. Moreover the indices of HA incidence among the vaccinated were lower in 5-7 times than in the comparative groups.
