Serum 25-hydroxyvitamin D and bone mineral density among Hispanic men.

UNLABELLED: There are few data on the skeletal health of Hispanic men. We observed differences in vitamin D deficiency and low BMD between Hispanic ethnic subgroups that persisted with adjustment for risk factors. Our data indicate a substantial burden of low BMD and vitamin D deficiency among Hispanic men. INTRODUCTION: Disparities within ethnic groups are generally ignored, but in evolving populations they may have implications for public health. We examined ethnic variation in serum 25-hydroxyvitamin D [25(OH)D] and bone mineral density (BMD) among Hispanic American men. METHODS: Three hundred and fifty-eight Hispanic males 30 to 79 years of age were studied. Logistic regression models assessed variation in odds of vitamin D deficiency (<20 ng/mL) and low BMD (T-score<-1) by ethnicity, with and without adjustment for risk factors (age, smoking, occupation, physical activity, body mass index, and sunlight exposure). RESULTS: Vitamin D deficiency was most common among Puerto Rican (26%), compared with Dominican (21%), Central American (11%), and South American (9%) men. Percentages with low BMD were: South American (44%), Puerto Rican (34%), Dominican (29%), and Central American (23%). Adjustment for age and risk factors failed to account for Hispanic subgroup differences in vitamin D deficiency and low BMD. Population estimates indicate a substantial burden of low BMD and vitamin D deficiency among Hispanic men. CONCLUSIONS: Our findings underscore the importance of examining the skeletal health of Hispanic subgroups, and suggest that a considerable number of Hispanic men may be at elevated risk of fracture and vitamin D deficiency.

The relationship between body composition and bone mineral content: threshold effects in a racially and ethnically diverse group of men.

UNLABELLED: We examined BMC and body composition in 1,209 black, Hispanic, and white men. Weight, BMI, waist circumference, and fat mass were associated with BMC only up to certain thresholds, whereas lean mass exhibited more consistent associations. The protective influence of increased weight appears to be driven by lean mass. INTRODUCTION: Reduced body size is associated with decreased bone mass and increased fracture risk, but associations in men and racially/ethnically diverse populations remain understudied. We examined bone mineral content (BMC) at the hip, spine, and forearm as a function of body weight, body mass index (BMI), waist circumference, fat mass (FM), and nonbone lean mass (LM). METHODS: The design was cross-sectional; 363 non-Hispanic black, 397 Hispanic, and 449 non-Hispanic white residents of greater Boston participated (N = 1,209, ages 30-79 y). BMC, LM, and FM were measured by DXA. Multiple linear regression was used to describe associations. RESULTS: Weight, BMI, waist circumference, and FM were associated with BMC only up to certain thresholds. LM, by contrast, displayed strong and consistent associations; in multivariate models, femoral neck BMC exhibited a 13% increase per 10 kg cross-sectional increase in LM. In models controlling for LM, positive associations between BMC and other body composition measures were eliminated. Results did not vary by race/ethnicity. CONCLUSIONS: The protective effect of increased body size in maintaining bone mass is likely due to the influence of lean tissue. These results suggest that maintenance of lean mass is the most promising strategy in maintaining bone health with advancing age.

Age trends in proximal femur geometry in men: variation by race and ethnicity.

UNLABELLED: Data on bone architecture in diverse male populations are limited. We examined proximal femur geometry in 1,190 black, Hispanic, and white men. Cross-sectional analyses indicate greatest bone strength among black men, and greater age-related differences in bone strength among Hispanic men than other subjects at the narrow neck and intertrochanter regions of the proximal femur. INTRODUCTION: Although race/ethnic differences in bone mass are well-documented, less is known about differences in bone architecture. We examined proximal femur geometry in a diverse, randomly-sampled population of 1,190 community-dwelling men (age 30-79 y). METHODS: Dual X-ray absorptiometry scans were obtained for 355 black, 394 Hispanic, and 441 white subjects. Measures were obtained for the narrow neck (NN), intertrochanter (IT) and shaft regions of the proximal femur via hip structural analysis. Analyses considered bone mineral density (BMD, g/cm2), outer diameter (cm), cross-sectional area (CSA, cm2), section modulus (Z, cm3), and buckling ratio (BR). Results were adjusted for height, weight and physical activity level. RESULTS: Black subjects exhibited greater age-specific BMD, CSA and Z, than their white counterparts. For instance, at age 50 y, NN BMD was approximately 11% higher among black men (p < 0.001). Hispanic men exhibited sharper age-related differences in NN and IT BMD than did others. IT BMD, for instance, decreased by 2.4% with 10 y age among Hispanic subjects, but had virtually no age trend in others (p < 0.001). CONCLUSIONS: These results imply greater bone strength among black American men than among their white counterparts, and may indicate elevated fracture risk among older Hispanic American subpopulations.

[Octreotide scintigraphy for the diagnosis of active Graves' ophthalmopathy]. / Oktreotidszintigraphie zur Diagnose der aktiven endokrinen Orbitopathie.

PURPOSE: In this study the diagnostic accuracy of orbital octreotide uptake in patients with presumed active Grave's ophthalmopathy (GO) was evaluated. PATIENTS AND METHODS: A prospective study of 23 patients suffering from GO was carried out. Single photon emission computed tomography (SPECT) images were obtained 4 h after iv injection of 3 mCi 111 indium octreotide. The results were correlated with the patients clinical state during a follow-up of 17.5+/-6 months. RESULTS: Octreotide scintigraphy was positive in 15 and negative in 8 cases, 12 patients with positive octreotide scintigraphy underwent immunosuppressive treatment and showed a clinically positive response with regression of symptoms. In three cases the patients refused immunosuppressive treatment. Patients with negative pathologic orbital octreotide uptake did not undergo any treatment. CONCLUSION: Octreotide scintigraphy is a useful tool to determine the activity state of Graves' ophthalmopathy. Since Graves' ophthalmopathy must be treated in the active phase, octreotide scintigraphy should be performed in subacute cases to facilitate the indications for immunosuppressive treatment.