ABSTRACT
Optical microcavities grant manipulation over light-matter interactions and light propagation, enabling the fabrication of foundational optical and optoelectronic components. However, the materials used for high-performing systems, mostly bulk inorganics, are typically costly, and their processing is hardly scalable. In this work, we present an alternative way to fabricate planar optical resonators via solely solution processing while approaching the performances of conventional systems. Here, we couple fully solution-processed high dielectric contrast inorganic Bragg mirrors obtained by sol-gel deposition with the remarkable photoluminescence properties of CsPbBr3 perovskite nanocrystals. The approach yields microcavities with a quality factor of â¼220, which is a record value for solution-processed inorganic structures, and a strong emission redistribution resulting in a 3-fold directional intensity enhancement.
ABSTRACT
Variation in the tryptophan hydroxylase-2 gene (TPH2) coding for the rate-limiting enzyme of serotonin (5-HT) synthesis in the brain modulates responses of limbic circuits to emotional stimuli and has been linked to a spectrum of clinical populations characterized by emotional dysregulation. Here, we tested a set of common single nucleotide polymorphisms (SNPs) in and downstream of the transcriptional control region of TPH2 for association with personality traits and with risk for personality disorders in two cohorts comprising of 336 healthy individuals and 420 patients with personality disorders. Personality dimensions were assessed by the Tridimensional Personality Questionnaire (TPQ) and the revised NEO Personality Inventory (NEO-PI-R). Personality disorders were diagnosed with the Structured Clinical Interview of DSM-IV and were allocated to clusters A, B, and C. Individual SNP and haplotype analyses revealed significant differences in genotype frequencies between controls and cluster B as well as cluster C patients, respectively. In both patient groups, we observed overrepresentation of T allele carriers of a functional polymorphism in the upstream regulatory region of TPH2 (SNP G-703T, rs4570625) which was previously shown to bias responsiveness of the amygdala, a structure critically involved in emotionality. Furthermore, significant effects of TPH2 variants on anxiety-related traits defined primarily by the TPQ Harm Avoidance were found in healthy individuals. The results link potentially functional TPH2 variants to personality traits related to emotional instability as well as to cluster B and cluster C personality disorders. These findings implicate alterations of 5-HT synthesis in emotion regulation and confirm TPH2 as a susceptibility and/or modifier gene of affective spectrum disorders.
