ABSTRACT
Background: In Chile, patients with hereditary angioedema (HAE) type I and type II are protected under Ley Ricarte Soto (LRS), which guarantees access to on demand plasma-derived C1-INH (pdC1-INH) since 2018. We aimed to analyze the first 3 years of LRS. Methods: Review of the LRS database between 2018 and 2021. Results: During the study period, 154 patients were covered by LRS, with an estimated prevalence of HAE in Chile at 0.8:100,000 inhabitants. A delay in diagnosis of 22 years was noted, 50 patients received epinephrine during an attack before the diagnosis of HAE. Mean number of attacks per year was 8, with 50% of adults and 42% of children experiencing more than 1 attack per month. Conclusion: Disease awareness must improve to reduce the diagnostic delay of HAE. Long-term prophylactic medications should be included in LRS to treat patients with high attack rates and control the costs of frequent on-demand treatment with pdC1-INH.
Subject(s)
Angioedemas, Hereditary , Adult , Child , Humans , Angioedemas, Hereditary/diagnosis , Angioedemas, Hereditary/drug therapy , Angioedemas, Hereditary/epidemiology , Chile/epidemiology , Delayed Diagnosis , Treatment Outcome , PlasmaABSTRACT
We present an Identify Selective Antibacterial Peptides (ISAP) approach based on abstracts meaning. Laboratories and researchers have significantly increased the report of their discoveries related to antibacterial peptides in primary publications. It is important to find antibacterial peptides that have been reported in primary publications because they can produce antibiotics of different generations that attack and destroy the bacteria. Unfortunately, researchers used heterogeneous forms of natural language to describe their discoveries (sometimes without the sequence of the peptides). Thus, we propose that learning the words meaning instead of the antibacterial peptides sequence is possible to identify and predict antibacterial peptides reported in the PubMed engine. The ISAP approach consists of two stages: training and discovering. ISAP founds that the 35% of the abstracts sample had antibacterial peptides and we tested in the updated Antimicrobial Peptide Database 2 (APD2). ISAP predicted that 45% of the abstracts had antibacterial peptides. That is, ISAP found that 810 antibacterial peptides were not classified like that, so they are not reported in APD2. As a result, this new search tool would complement the APD2 with a set of peptides that are candidates to be antibacterial. Finally, 20% of the abstracts were not semantic related to APD2.
Subject(s)
Antimicrobial Cationic Peptides/chemistry , Computational Biology/methods , Algorithms , Bacterial Infections/drug therapy , Databases, Protein , Drug Design , Humans , Language , Models, Statistical , Natural Language Processing , Peptides/chemistry , PubMed , Reproducibility of Results , Semantics , SoftwareABSTRACT
Se estudian 25 pacientes portadores de estenosis mitral pura, de los cuales 6 presentan además fibrilación auricular. Se analiza la determinación del área valvular mitral por ecocardiografía bidimensional y ecocardiografía Doppler, mostrándose que entre ambos métodos existe una correlación estadísticamente válida. Se logra demostrar también que los pacientes portadores de estenosis más severa tienen mayor grado de dilatación de aurícula izquierda. Por último, se concluye que los pacientes portadores de estenosis mitral que presentan fibrilación auricular corresponden a los grados más críticos de estenosis y de dilatación auricular izquierda
