Reordenamiento de la oferta de servicios de salud para la atención de recién nacidos en Lima Metropolitana en las IPRESS del Ministerio de Salud, 2015-2019 / Rearrangement of the supply of health services for newborn care in Metropolitan Lima in the IPRESS of the Ministry of Health, 2015-2019

La morbimortalidad materno-neonatal es un problema de salud pública en el Perú. El Ministerio de Salud ha diseñado diversas intervenciones que permiten enfrentar este problema tales como planificación familiar, atención del parto por profesional de salud y atención prenatal reenfocada; las cuales son parte del Programa Presupuestal (PP) Salud Materno Neonatal que es ejecuta en los establecimientos de salud del país del MINSA y de los Gobiernos Regionales.

Neonatal maternal morbidity and mortality is a public health problem in Peru. The Ministry of Health (MINSA) has designed various interventions to address this problem, such as family planning, delivery care by a health professional, and refocused prenatal care; which are part of the Budgetary Program (PP) Maternal Neonatal Health that is executed in the health establishments of the country of the MINSA and the Regional Governments.

Financiamiento en la capacitación de los profesionales en salud bajo la perspectiva del sector público, 2016-2018 / Financing in the training of health professionals from the perspective of the public sector, 2016-2018

Objetivo: Estimar el financiamiento y costo unitario en la capacitación a largo plazo de los profesionales de salud en el Perú. Métodos: Se realizó una evaluación económica parcial (análisis de costos) desde la perspectiva del financiador público. Para el financiamiento se muestra reportes por categorías presupuestales y programas presupuestales del sector salud, los datos se obtuvieron a través del Sistema Integrado de Administración Financiera del Ministerio de Economía y finanzas (SIAF-MEF) entre los años 2016 ­ 2018. En relación al análisis de costo se estimó con la metodología de costeo por absorción. Los datos se obtuvieron del Sistema Integrado de gestión Administrativa (SIGA)- modulo logístico para obtener los precios de los insumosy del aplicativo Informático de Recursos Humanos de Servidores Públicos (AIRHSP) para los sueldos de los recursos humanos. Resultados: Financiamiento que hace el país en relación a capacitación se estima en 27 millones de soles para el año 2016, y se reduce a 20 millones de soles para el año 2018. El costo per cápita para diplomados fue de S/.12 661 (USD 3 836) y para la especialización fue de S/. 23 356 (USD 7 077). Conclusión: el financiamiento en la formación del recurso humano en salud es vital para el logro de los objetivos sanitarios en el Perú. Sin embargo existe una disminución del presupuesto destinado a actividades de capacitación en los últimos 3 años.

Objective: To estimate the funding and unit cost in the long-term training of health professionals in Peru. Methods: A partial economic evaluation (cost analysis) was carried out from the perspective of the public financier. For financing, reports are shown by budget categories and budget programs of the health sector. Data was obtained through the Integrated System of Financial Administration of the Ministry of Economy and Finance (SIAF-MEF) between the years 2016 - 2018. In relation to the analysis The cost was estimated using the absorption costing methodology. The data was obtained from the Integrated System of Administrative Management (SIGA) - logistic module to obtain the prices of the inputs, the Computer Application of Human Resources of Public Servants (AIRHSP) for salaries of human resources. Results: Financing made by the country in relation to training is estimated at 27 million soles for 2016, and it is reduced to 20 million soles by 2018. The per capita cost for graduates was S /. 12 661 (USD 3 836) and for the specialization it was S /. 23 356 (USD 7 077). Conclusion: Financing in the formation of human resources in health is vital for the achievement of health objectives in Peru. However, there is a decrease in the budget allocated to training activities in the last 3 years.

Workplace violence by specialty among Peruvian medical residents.

OBJECTIVE: To determine the prevalence of workplace violence among Peruvian medical residents and to evaluate the association between medical specialty and workplace violence per type of aggressor. METHODS: This was a cross-sectional secondary analysis that used data from the Peruvian Medical Residents National Survey 2016 (ENMERE-2016). The outcome of interest was workplace violence, including physical and verbal violence, which were categorized according to the perpetrator of violence (patients/relatives and worker-to-worker). Primary exposure was the medical specialty, categorized as clinical, surgical, and other specialties. To evaluate the associations of interest, we estimated adjusted prevalence ratios (PR) with their respective 95% confidence intervals (95% CI) using Poisson regression models with robust variances. RESULTS: A total of 1054 Peruvian medical residents were evaluated. The mean age was 32.6 years and 42.3% were female. Overall 73.4% reported having suffered of workplace violence sometime during the residency, 34.4% reported violence from patients/relatives, and 61.1% reported worker-to-worker violence. Compared with clinical residents, surgical residents had a lower prevalence of violence from patients/relatives (PR: 0.71; 95% CI: 0.59-0.87), but a higher prevalence of worker-to-worker violence (PR: 1.11, 95% CI: 1.01-1.23). CONCLUSION: Nearly three quarters of medical residents reported having suffered workplace violence sometime during their residency. Compared with clinical residents, surgical residents had lower rates of violence from patients/relatives, but higher rates of worker-to-worker violence; while residents from non-clinical and non-surgical specialties had a lower prevalence of both types of violence.

Prevalencia y factores asociados a publicar artículos científicos durante la residencia médica en Perú / Prevalence and associated factors to publish scientific articles during the medical residency in Peru

Objetivo. Determinar la prevalencia y los factores asociados a publicar artículos científicos en médicos residentes de Perú. Sujetos y métodos. Estudio transversal analítico usando los datos obtenidos por la Encuesta Nacional para Médicos Residentes 2016 (ENMERE-2016), realizada virtualmente durante junio de 2016. Población: los médicos que realizan su residencia en alguna universidad de Perú. Muestra: los residentes que voluntariamente participaron en la ENMERE-2016. Desenlace de interés: autorreporte de haber publicado al menos un artículo científico. Se recogieron variables sociodemográficas, de la universidad, de la sede, de la residencia, de la percepción del residente y de síntomas depresivos. Para evaluar los factores asociados a haber publicado algún artículo científico se calcularon razones de prevalencia crudas y ajustadas con sus intervalos de confianza al 95%. Resultados. Se analizaron datos de 1.062 residentes (42,2% de sexo femenino), de los cuales 118 (11,1%) publicaron algún artículo científico durante la residencia. En el análisis ajustado, cursar los años superiores de la residencia, haber realizado alguna rotación externa fuera del país y tener una puntuación más alta en la opinión global del proceso de formación fueron variables directamente asociadas con haber publicado algún artículo científico, en tanto que el sexo femenino, tener más de 35 años y presentar síntomas depresivos fueron variables inversamente asociadas a dicho desenlace. Conclusión. Aproximadamente uno de cada 10 residentes publicó algún artículo científico durante la residencia. Esto fue menos prevalente en las mujeres, en los residentes de mayor edad, en quienes cursaban años inferiores de la residencia, en quienes no realizaron ninguna rotación fuera del país, en quienes tuvieron una peor opinión del proceso de formación y en quienes presentaban síntomas depresivos

Aim. To determine the prevalence and the factors associated with the publication of scientific articles in medical residents of Peru. Subjects and methods. Cross-sectional analytical study using the data obtained by the National Survey for Resident Physicians 2016 (ENMERE-2016), carried out virtually during June 2016. Population: physicians who live in a university in Peru. Sample: residents who voluntarily participated in ENMERE-2016. Outcome of interest: have published at least one scientific article. Sociodemographic variables were collected, from the university, from the headquarters, from the residence, from the residen's perception, and from depressive symptoms. To evaluate the factors associated with having published a scientific article, crude and adjusted prevalence ratios were calculated with their 95% confidence intervals. Results. Data from 1062 residents (42.2% female) were analyzed, of which 118 (11.1%) published some scientific paper during the resident. In the adjusted analysis, to study the superior years of residency, to have performed some external rotation outside the country and to have a higher score in the overall opinion of the training process were variables directly associated with having published some scientific article. While the female sex, being over 35 years old and presenting with depressive symptoms were variables inversely associated with this outcome. Conclusion. Approximately one in ten residents published a scientific article during the residency. This was less prevalent in women, in older residents, in those who were in lower years of residence, in those who did not perform any rotation outside the country, in those who had a worse opinion of the training process, and in those with depressive symptoms

[Cost-Fffectiveness of Two Antiviral Therapies for Chronic Hepatitis B in Peru: Entecavir and Tenofovir]. / Costo-efectividad de dos terapias antivirales para Hepatitis B crónica en el Perú: Entecavir y tenofovir.

OBJETIVES: To compare in terms of cost-effectiveness to entecavir (ETV) and tenofovir (TDF) in the treatment of hepatitis B virus (HBV) in public hospitals in Peru. MATERIALS AND METHODS: We structured a Markov model. We define effectiveness adjusted life years for quality (QALY). We include the direct costs of treatment in soles from the perspective of the Ministry of Health of Peru. We estimate the relationship between cost and effectiveness ratios (ICER). We performed sensitivity analyzes considering a range of willingness to pay (WTP) from one to three times the Gross Domestic Product (GDP) per capita, and a tornado analysis regarding Monetary Net Profit (BMN) or ICER. RESULTS: Treatment with TDF is more effective and less expensive than ETV. The ETV had a cost per QALY of PEN 4482, and PEN 1526 TDF. The PTO maintains a progressively larger with increasing WTP BMN. The discount rate was the only variable with a significant effect on model uncertainty. CONCLUSION: Treatment with TDF is more cost-effective than ETV in public hospitals in Peru.

OBJETIVOS: Comparar en términos de costo-efectividad a entecavir (ETV) y tenofovir (TDF) en el tratamiento del virus de la hepatitis B (HBV) en hospitales públicos del Perú. MATERIALES Y MÉTODOS: Estructuramos un modelo de Markov, definimos la efectividad en años de vida ajustados a calidad (AVAC). Incluimos los costos directos del tratamiento en soles desde la perspectiva del Ministerio de Salud del Perú. Calculamos la relación entre costo y efectividad incrementales (ICER). Realizamos análisis de sensibilidad determinístico y probabilístico, considerando un rango de disponibilidad de pago (WTP) desde uno hasta tres veces el producto bruto interno (PBI) per-cápita, y el beneficio monetario neto (BMN) o ICER en el caso del análisis de tornado. RESULTADOS: El tratamiento con TDF es más efectivo y menos costoso que ETV. El ETV tuvo un costo por AVAC de S/ 4482, y de S/ 1526 para TDF. El TDF mantiene un BMN progresivamente mayor conforme aumenta la WTP. La tasa de descuento fue la única variable con efecto significativo en la incertidumbre del modelo. CONCLUSIONES: El tratamiento con TDF es más costo-efectivo que ETV en hospitales públicos del Perú.

Características del residentado médico en el Perú: resultados de la primera Encuesta Nacional de Médicos Residentes (ENMERE-2016) / Characteristics of the medical residency in Peru: results of the first National Survey of Medical Residents (ENMERE-2016)

Objetivo: Describir las características laborales, académicas y de investigación de los médicos participantes en el programa de residentado peruano durante el año 2016. Materiales y métodos: Estudio observacional, descriptivo y transversal; mediante el análisis secundario de la Encuesta Nacional para Médicos Residentes (ENMERE-2016) del año 2016 realizada por el Comité Nacional de Residentado Médico del Perú, mediante encuestas virtuales y voluntarias dirigidas a todos los médicos residentes de Perú. Resultados: De los 7 393 médicos que encontraban realizando el residentado médico en el año 2016, 1 196 (16,2%) respondieron al menos una pregunta de la ENMERE-2016. En esta muestra, la edad promedio fue 32,7 ± 5,6 años, el 57,1% fue de sexo masculino, y el 64,1% realizaba su residentado por una universidad de Lima. El 46,1% de los médicos residentes estaban satisfechos con la función de su tutor, el 14,7% presentaron síntomas depresivos, el 80,9% no había tenido descanso posguardia en el último mes (después de una guardia nocturna), el 48,3% podia retirarse de su sede después de las 14:00 horas el día después de una guardia nocturna, el 38,6% afirmó recibir material de bioseguridad (en su hospital de residencia) siempre que lo necesitara, y el 16,1% había realizado al menos un trabajo de investigación durante su residencia. Conclusión: Los resultados de la ENMERE-2016 reportaron diversas falencias en las características laborales, académicas, y de investigación durante el residentado médico en Perú. Palabras clave: Internado y residencia; Médicos; Recursos humanos en salud; Satisfacción en el trabajo; Educación médica (fuente: DeCS BIREME)

Objective: To describe the working, academic, and research conditions for physicians in training in the Peruvian medical residency program during 2016. Materials and methods: This is an observational, descriptive and cross-sectional study that performed a secondary analysis of the National Survey for Medicine Residents (ENMERE-2016, according to its Spanish initials) developed by the Peruvian Committee for Medical Residency. Surveys were virtual and voluntary, and they were sent to all medical residents in Peru. Results: Of the 7393 physicians that were in a residency program during 2016, 1196 (16.2%) responded at least one question of the ENMERE-2016. In this sample, the average age was 32.7 ± 5.6 years, 57.1% residents were male, and 64.1% were having their training in a medical school in Lima. Nearly half (46.1%) of residents were satisfied with their tutors, 14.7% had depressive symptoms, and 80.9% did not have a resting period after a night shift during the last month. Nearly half of the residents were able to get out of their hospitals after 14.00 hours the day after a night shift; 38.6% reported having received biosafety material for their protection in their hospitals when needed, and 16.1% reported having performed at least one research project during their training period. Conclusion: The ENMERE-2016 results reported many failures in labor, academic, and research aspects during the medical residency programs in Peru

Costo-efectividad de dos terapias antivirales para Hepatitis B crónica en el Perú: Entecavir y tenofovir / Cost-Fffectiveness of Two Antiviral Therapies for Chronic Hepatitis B in Peru: Entecavir and Tenofovir

RESUMEN Objetivos Comparar en términos de costo-efectividad a entecavir (ETV) y tenofovir (TDF) en el tratamiento del virus de la hepatitis B (HBV) en hospitales públicos del Perú. Materiales y métodos Estructuramos un modelo de Markov, definimos la efectividad en años de vida ajustados a calidad (AVAC). Incluimos los costos directos del tratamiento en soles desde la perspectiva del Ministerio de Salud del Perú. Calculamos la relación entre costo y efectividad incrementales (ICER). Realizamos análisis de sensibilidad determinístico y probabilístico, considerando un rango de disponibilidad de pago (WTP) desde uno hasta tres veces el producto bruto interno (PBI) per-cápita, y el beneficio monetario neto (BMN) o ICER en el caso del análisis de tornado. Resultados El tratamiento con TDF es más efectivo y menos costoso que ETV. El ETV tuvo un costo por AVAC de S/ 4482, y de S/ 1526 para TDF. El TDF mantiene un BMN progresivamente mayor conforme aumenta la WTP. La tasa de descuento fue la única variable con efecto significativo en la incertidumbre del modelo. Conclusiones El tratamiento con TDF es más costo-efectivo que ETV en hospitales públicos del Perú.

ABSTRACT Objetives To compare in terms of cost-effectiveness to entecavir (ETV) and tenofovir (TDF) in the treatment of hepatitis B virus (HBV) in public hospitals in Peru. Materials and methods We structured a Markov model. We define effectiveness adjusted life years for quality (QALY). We include the direct costs of treatment in soles from the perspective of the Ministry of Health of Peru. We estimate the relationship between cost and effectiveness ratios (ICER). We performed sensitivity analyzes considering a range of willingness to pay (WTP) from one to three times the Gross Domestic Product (GDP) per capita, and a tornado analysis regarding Monetary Net Profit (BMN) or ICER. Results Treatment with TDF is more effective and less expensive than ETV. The ETV had a cost per QALY of PEN 4482, and PEN 1526 TDF. The PTO maintains a progressively larger with increasing WTP BMN. The discount rate was the only variable with a significant effect on model uncertainty. Conclusion Treatment with TDF is more cost-effective than ETV in public hospitals in Peru.

[Evaluation of the cost-effectiveness of two alternative human papillomavirus vaccines as prophylaxis against uterine cervical cancer]. / Evaluación costo-efectividad de dos alternativas de vacunación para el virus del papiloma humano en la prevención del cáncer cervical uterino.

OBJECTIVES.: To determine the cost-effectiveness of human papillomavirus (HPV) vaccination and cervical lesion screening versus screening alone for the prevention of uterine cervical cancer (UCC). MATERIALS AND METHODS.: This cost-effectiveness evaluation from the perspective of the Ministry of Health employed a Markov model with a 70-year time horizon and three alternatives for UCC prevention (screening alone, screening + bivalent vaccine, and screening + quadrivalent vaccine) in a hypothetical cohort of 10-year-old girls. RESULTS.: Our model, which was particularly sensitive to variations in coverage and in the prevalence of persistent infection by oncologic genotypes not included in the vaccine, revealed that HPV vaccination and screening is more cost-effective than screening alone, assuming a payment availability from S/ 2 000 (US dollars (USD) 1 290.32) per subject. In the deterministic analysis, the bivalent vaccine was marginally more cost-effective than the quadrivalent vaccine (S/ 48 [USD 30.97] vs. S/ 166 [USD 107.10] per quality-adjusted life-year, respectively). However, in the probabilistic analysis, both interventions generated clouds of overlapping points and were thus cost-effective and interchangeable, although the quadrivalent vaccine tended to be more cost-effective. CONCLUSIONS.: Assuming a payment availability from S/ 2000 [USD 1,290.32], screening and vaccination were more cost-effective than screening alone. The difference in cost-effectiveness between the two vaccines lacked probabilistic robustness, and therefore the vaccines can be considered interchangeable from a cost-effectiveness perspective.

Evaluación costo-efectividad de dos alternativas de vacunación para el virus del papiloma humano en la prevención del cáncer cervical uterino / Evaluation of the cost-effectiveness of two alternative human papillomavirus vaccines as prophylaxis against uterine cervical cancer

RESUMEN Objetivos. Determinar la relación costo-efectividad de la vacunación contra el (virus del papiloma humano) VPH y el tamiz de lesiones cervicales, frente a un programa de tamiz solo. Materiales y métodos. Se realizó una evaluación costo-efectividad y se empleó un modelo de Markov, con un horizonte temporal de 70 años y tres alternativas de prevención para el (cáncer del cuello uterino) CCU (tamiz solo, tamiz + vacuna bivalente, y tamiz + vacuna cuadrivalente), en una cohorte hipotética de niñas de diez años, desde la perspectiva del Ministerio de Salud. Resultados. La vacunación contra el VPH y tamiz es más costo-efectiva que el tamiz solo a partir de una voluntad de pago de S/ 2000 (USD 1 290,32). En el análisis determinístico, la vacuna bivalente es marginalmente más costo-efectiva que la vacuna cuadrivalente (S/ 48 [USD 30,97] frente a S/ 166 [USD 107,10] por AVAC, respectivamente). Sin embargo, en el análisis probabilístico ambas intervenciones generan nubes de puntos superpuestos, con una tendencia de la vacuna cuadrivalente a ser más costo-efectiva. Es decir, ambas son costo-efectivas y, por ende, intercambiables. El modelo fue especialmente sensible a variaciones de la cobertura y en la prevalencia de infección persistente por genotipos oncológicos no incluidos en la vacuna. Conclusiones. A partir de una disponibilidad de pago de S/ 2000 [USD 1 290,32] el tamiz y la vacunación son más costo-efectivos que el tamiz solo. La diferencia de costo-efectividad entre ambas vacunas carece de robustez probabilística y ambas vacunas pueden considerarse intercambiables desde la perspectiva costo-efectividad.

ABSTRACT Objectives. To determine the cost-effectiveness of human papillomavirus (HPV) vaccination and cervical lesion screening versus screening alone for the prevention of uterine cervical cancer (UCC). Materials and methods. This cost-effectiveness evaluation from the perspective of the Ministry of Health employed a Markov model with a 70-year time horizon and three alternatives for UCC prevention (screening alone, screening + bivalent vaccine, and screening + quadrivalent vaccine) in a hypothetical cohort of 10-year-old girls. Results. Our model, which was particularly sensitive to variations in coverage and in the prevalence of persistent infection by oncologic genotypes not included in the vaccine, revealed that HPV vaccination and screening is more cost-effective than screening alone, assuming a payment availability from S/ 2 000 (US dollars (USD) 1 290.32) per subject. In the deterministic analysis, the bivalent vaccine was marginally more cost-effective than the quadrivalent vaccine (S/ 48 [USD 30.97] vs. S/ 166 [USD 107.10] per quality-adjusted life-year, respectively). However, in the probabilistic analysis, both interventions generated clouds of overlapping points and were thus cost-effective and interchangeable, although the quadrivalent vaccine tended to be more cost-effective. Conclusions. Assuming a payment availability from S/ 2000 [USD 1,290.32], screening and vaccination were more cost-effective than screening alone. The difference in cost-effectiveness between the two vaccines lacked probabilistic robustness, and therefore the vaccines can be considered interchangeable from a cost-effectiveness perspective.

Cost-effectiveness analysis of 10- and 13-valent pneumococcal conjugate vaccines in Peru.

OBJECTIVE: To evaluate the cost-effectiveness of introducing the 10-valent pneumococcal conjugate vaccine (PCV10) versus the 13-valent PCV (PCV13) to the National Immunization Schedule in Peru for prevention of pneumococcal disease (PD) in children <5 years of age. METHODS: The integrated TRIVAC vaccine cost-effectiveness model from the Pan American Health Organization's ProVac Initiative (version 2.0) was applied from the perspective of the Government of Peru. Twenty successive cohorts of children from birth to 5 years were evaluated. Clinical outcomes were pneumococcal pneumonia (PP), pneumococcal meningitis (PM), pneumococcal sepsis (PS) and acute otitis media from any causes (AOM). Measures included prevention of cases, neurological sequelae (NS), auditory sequelae (AS), deaths and disability adjusted life years (DALYs). A sensitivity analyses was also performed. FINDINGS: For the 20 cohorts, net costs with PCV10 and PCV13 were US$ 363.26 million and US$ 408.26 million, respectively. PCV10 prevented 570,273 AOM; 79,937 PP; 2217 PM; 3049 PS; 282 NS; 173 AS; and 7512 deaths. PCV13 prevented 419,815 AOM; 112,331 PN; 3116 PM; 4285 PS; 404 NS; 248 AS; and 10,386 deaths. Avoided DALYs were 226,370 with PCV10 and 313,119 with PCV13. Saved treatment costs were US$ 37.39 million with PCV10 and US$ 47.22 million with PCV13. Costs per DALY averted were US$ 1605 for PCV10, and US$ 1304 for PCV13. Sensitivity analyses showed similar results. PCV13 has an extended dominance over PCV10. CONCLUSION: Both pneumococcal vaccines are cost effective in the Peruvian context. Although the net cost of vaccination with PCV10 is lower, PCV13 prevented more deaths, pneumococcal complications and sequelae. Costs per each prevented DALY were lower with PCV13. Thus, PCV13 would be the preferred policy; PCV10 would also be reasonable (and cost-saving relative to the status quo) if for some reason 13-valent were not feasible.

Módulo básico de estadística / Estatistics basic module

Este módulo presenta una compilación externa de material bibliográfico seleccionado por especialistas en la materia y que constituye un material de consulta técnico-didáctico importante en la formación y capacitación del personal técnico en estadística del Sector Salud y del personal de estadística en general