1.
Bioorg Med Chem
; 15(17): 5719-37, 2007 Sep 01.
Article
in English
| MEDLINE
| ID: mdl-17590342
ABSTRACT
Several sesterterpenolides analogues of dysidiolide have been synthesized and their in vitro antitumoural activity against human HeLa, A549, HT-29 and HL-60 carcinoma cells is presented. The proliferation inhibition data showed a significant antitumour activity of the compounds 1b, 2a, 2b, 3a, 3b, 4a, 4b, 5, inhibiting proliferation of distinct cancer cell types with an IC(50) in the low micromolar range.