[Experimental morphological basis of the application of microsurgical intestinal suture under the conditions of inflammatory pathology of gastro-intestinal tract organs].

Experimental study of morphological peculiarities of intestinal wall and common bile duct wall healing using microsurgical sutures under the condition of peritonitis and cholangitis, was performed in 112 dogs. It was shown that the microsurgical suturing of intestinal wall and common bile duct wall affected by the inflammatory process, created the favorable conditions for wound healing. During the recovery period, the thickness of all the layers of the intestinal wall decreased, the disturbances of the normal fibrous structure and the vascular reaction of the submucosa were reduced. Connective tissue capsule was formed around the threads. The structure of the suture zone was not different from that of the neighboring areas of the intestine.

[Morphological analysis of intestinal wound and interintestinal anastomosis healing after the application of microsurgical techniques under the experimental conditions].

This paper presents the data of the morphological analysis of the healing of small intestine wounds as well as colon wounds and anastomoses created using the microsurgical operative techniques. The possibility of application and the efficacy of microsurgical technique was shown for the suturing of small intestine wounds during stage I and II peritonitis and large intestine anastomoses during the colonic passage disturbances with the epithelization by day 7. The significance of colon wall microanatomical peculiarities for the application of the microsurgical technique was determined. The possibility of wound and intestinal colonic anastomosis healing according to the primary type during the period of 4-6 days without the dense connective tissue scar formation is proved.

[Morphological characteristic of wound healing process in patients with diabetic purulent-necrotic foot lesion treated with oxytocin]. / Morfologicheskaia kharakteristika ranevogo protsessa u bol'nykh s diabeticheskimi gnoino-nekroticheskimi porazheniiami stop pri vozdeistvii oksitotsinom.

Wound healing was studied in 90 patients with "diabetic foot" receiving complex treatment which included oxytocin (40 patients) or did not use it (50 patients). Intraarterial injection or local application of oxytocin resulted in significant differences of wound process characteristics as compared with those ones in control group. The necrobiotic and necrotic changes in the tissues of skin, subcutaneous adipose tissue and skeletal muscles, located within the purulent-necrotic foci, were less expressed. The number of sludged capillaries, as well as of arterioles and venules with the signs of microthrombosis, was significantly decreased. Simultaneously, the regenerative potential of endotheliocytes, fibroblasts and adventitial cells was increased, showing a significant stimulation of their DNA-synthesizing capacity. The histological findings obtained indicate that the introduction of oxytocin in complex treatment activates the processes of vasculogenesis, proliferation of endotheliocytes anf histiocytes, that, in turn, results in the effective clearance of the wound and optimal granulation tissue formation.

[The use of oxytocin in the combined treatment of suppurative-necrotic lesions of the feet in diabetic patients]. / Primenenie oksitotsina v kompleksnom lechenii pri gnoino-nekroticheskikh porazheniiakh stop u bol'nykh s sakharnym diabetom.

The results of treatment of 90 patients with diabetes mellitus and pyo-necrotic lesions of the feet were compared. Oxytocin was used in 40 of the patients. It was found that parenteral administration of oxytocin resulted in more favorable course of diabetes mellitus in such patients. The intra-arterial or local use of Oxytocin was found to reliably increase the DNA synthesis by the endothelial cells, fibroblasts and histiocytes, which in its turn creates favorable conditions for the reparative process in the wounds and allows quality of the treatment to be considerably improved.

[Role of dysbacteriosis in the development of surgical infection]. / O roli disbakterioza v razvitii khirurgicheskoi infektsii.

The intestinal microflora was examined in 230 patients operated on for abdominal abnormalities and injuries. There were profound intestinal microbiocenotic impairments as appeared as lower bifidobacteria, intensive growth of opportunistic (coccal) microorganisms. A direct relationship was established between the severity of dysbacteriosis and the incidence of pyoinflammatory complications in the postoperative period. The use of live bacterial preparations in the complex therapy of patients with expected and emergency abdominal diseases or injuries reduced the number of pyoinflammatory complications and improved the therapeutic outcomes of patients with peritonitis.