Estadificación quirúrgica del cáncer de pulmón de células no pequeñas: ¿cuándo deberíamos realizar de rutina la resección de los ganglios supraclaviculares? / Surgical staging of non-small cell lung carcinoma: when should we routinely resect supraclavicular lymph nodes?

RESUMEN Antecedentes: la evaluación precisa del estadio del carcinoma pulmonar luego del diagnóstico es esencial para la selección de una terapia apropiada. Objetivo: describir las características de los pacientes con carcinoma de pulmón de células no pequeñas en los cuales la resección ganglionar supraclavicular permitiría detectar metástasis ganglionares no palpables (N3-supraclavicular). Material y métodos: entre diciembre de 2016 y diciembre de 2019 se registraron los datos de pacientes a quienes se les realizó estadificación quirúrgica mediastinal para cáncer de pulmón de células no pequeñas mediante mediastinoscopia cervical y resección de los ganglios supraclaviculares. Resultados: fueron incluidos 60 pacientes, (hombres 76,7%). La media tumoral fue de 4,7 cm y la de estaciones ganglionares evaluadas fue de 2,37 ± 1,44 (DS). En todos se realizó la resección ganglionar supraclavicular y el resultado fue positivo para malignidad epitelial en 21 casos (35%). De los 21 casos N3-supraclavicular, 2 pacientes se registraron como skip metástasis; el resto se asoció a enfermedad mediastinal N2 (p=0,0424). Se observó una asociación significativa entre le presencia de tumor central y de N3-supraclavicular (p=0,0148). Conclusión: se sugiere realizar la resección ganglionar supraclavicular en pacientes con sospecha o confirmación de enfermedad ganglionar N2 y tumores centrales, antes de considerar un enfoque terapéutico multimodal que incluya la cirugía.

ABSTRACT Background: Accurate staging after the diagnosis of lung carcinoma is essential to select an appropriate therapy. Objective: The aim of the present study is to describe the characteristics of patients with non-small cell lung carcinoma in whom supraclavicular lymph node resection would detect non-palpable (N3 supraclavicular disease) lymph node metastases. Material and methods: Data from patients undergoing mediastinal surgical staging for non-small cell lung cancer using cervical mediastinoscopy and resection of supraclavicular lymph nodes were collected between December 2016 and December 2019. Results: A total of 60 patients were included; 76.6% were men. Mean tumor size was 4.7 cm ad mean lymph node stations evaluated by mediastinoscopy was 2.37 ± 1.44 (SD). All the patients underwent supraclavicular lymph node resection and the result was positive for epithelial carcinoma in 21 cases (35%). Of the 21 cases with N3 supraclavicular disease, 2 patients were recorded as skip metastases and the remaining cases were association with mediastinal N2 disease (p = 0.0424). There was a significant association between central tumor and N3 supraclavicular disease (p = 0.0148). Conclusion: Supraclavicular lymph node resection may be recommended in patients with suspected or confirmed N2 lymph node disease and central tumors, before considering a multimodal therapeutic approach including surgery.

Neumonía lipoidea exógena no fibrosante: a propósito de un caso / Non-Fibrosing Exogenous Lipoid Pneumonia: presentation of a case

La neumonía lipoidea exógena (NLE) es una patología inusual, que tiene una incidencia del 1% al 2,5%, y tiene su causa en la aspiración y la acumulación de lípidos de origen exógeno dentro de los alvéolos pulmonares. Cuando el agente aspirado es de composición oleosa, se desencadena una reacción inflamatoria pulmonar denominada neumonía lipoidea, que con el tiempo puede conducir a una fibrosis parenquimatosa irreversible. En ocasiones, se puede presentar en forma de lesiones nodulares, que obligan a un amplio diagnóstico diferencial, en el que desempeñan un papel fundamental los estudios por imágenes. Para el diagnóstico definitivo, se requiere confirmación histopatológica1. Presentamos un caso clínico de neumonía lipoidea que se presentó como masa pulmonar acompañada de infiltrados pulmonares bilaterales.

Exogenous lipoid pneumonia (ELP) is an unusual disease, with an incidence of 1 to 2.5%, caused by aspiration and accumulation of exogenous lipids in the pulmonary alveoli. When the aspirated agent has an oily composition, a pulmonary inflammatory reaction called lipoid pneumonia is triggered, which over time can lead to irreversible parenchymal fibrosis. Sometimes it can appear as nodular lesions that require a broad differential diagnosis, in which case imaging studies have a fundamental role. Histo pathological confirmation is required for definitive diagnosis1. We present a clinical case of lipoid pneumonia which appeared as a lung mass ac companied by bilateral pulmonary infiltrates.

Non-Fibrosing Exogenous Lipoid Pneumonia: presentation of a case / Neumonía lipoidea exógena no fibrosante: a propósito de un caso

ABSTRACT Exogenous lipoid pneumonia (ELP) is an unusual disease, with an incidence of 1 to 2.5%, caused by aspiration and accumulation of exogenous lipids in the pulmonary alveoli. When the aspirated agent has an oily composition, a pulmonary inflammatory reaction called lipoid pneumonia is triggered, which over time can lead to irreversible parenchymal fibrosis. Sometimes it can appear as nodular lesions that require a broad differential diagnosis, in which case imaging studies have a fundamental role. Histopathological confirmation is required for definitive diagnosis1. We present a clinical case of lipoid pneumonia which appeared as a lung mass accompanied by bilateral pulmonary infiltrates.

RESUMEN La neumonía lipoidea exógena (NLE) es una patología inusual, que tiene una incidencia del 1% al 2,5%, y tiene su causa en la aspiración y la acumulación de lípidos de origen exógeno dentro de los alvéolos pulmonares. Cuando el agente aspirado es de composición oleosa, se desencadena una reacción inflamatoria pulmonar denominada neumonía lipoidea, que con el tiempo puede conducir a una fibrosis parenquimatosa irreversible. En ocasiones, se puede presentar en forma de lesiones nodulares, que obligan a un amplio diagnóstico diferencial, en el que desempeñan un papel fundamental los estudios por imágenes. Para el diagnóstico definitivo, se requiere confirmación histopatológica1. Presentamos un caso clínico de neumonía lipoidea que se presentó como masa pulmonar acompañada de infiltrados pulmonares bilaterales.

Video-assisted thoracoscopic diaphragmatic plication.

The authors demonstrate a video-assisted thoracoscopic surgical technique for diaphragmatic plication, which is used to treat acquired diaphragmatic paralysis resulting from injury to the phrenic nerve. The objective of the surgical procedure is to return the abdominal contents to their normal position and restore optimal lung expansion by reducing the size of the diaphragmatic surface. Successful diaphragmatic plication improves lung function, reduces dyspnea, and restores quality of life.

[Self-expanding tracheobronchial stent for treatment of post-pneumonectomy bronchopleural fistulas]. / Stent traqueobronquial autoexpansible para el tratamiento de las fistulas broncopleurales post neumonectomias.

Introduction: Bronchopleural fistula represents a formidable complication after pneumonectomies. There are numerous surgical and endoscopic procedures for its treatment. Clinical Case: We present a case where a coated self-expanding nitinol stent was used to exclude a bronchopleural fistula. Result: significant improvement in air leakage was observed. Conclusion: We encourage the use of a covered metal stent in selected patients.

Introducción: La fistula broncopleural representa una complicación temible luego de las neumonectomias. Existen numerosos procedimientos quirúrgicos y endoscópicos para su tratamiento. Caso Clínico: Presentamos caso donde se utilizo un stent de nitinol autoexpansible recubierto para excluir fistula broncopleural. Resultado: se observo importante mejoría de la fuga aérea. Conclusión: alentamos el uso de stent metalico recubierto en pacientes seleccionados.

VATS sympathectomy for hyperhidrosis.

Excessive sweating in the hands, feet, and armpits is a difficult problem for people who suffer from it and is an increasingly frequent reason for consulting a thoracic surgeon. The existing medical treatments are only palliative, so primary hyperhidrosis is a definite indication for thoracic sympathectomy. This video tutorial shows in detail the 2-port videothoracoscopic surgical technique performed by our surgical team.

[Thoracoscopic approach of a complicated pleuro-biliary fistula, after a right hepatectomy]. / Abordaje toracoscópico de fístula bilio-pleural complicada, post hepatectomía derecha.

INTRODUCTION: Pleuro-biliary fistula is a rare complication that originates from various causes, including liver resections. There is no consensus on how to manage them. There are 2 types of treatment: surgical and conservative. Both can be combined. The latter involves the combination of minor surgical procedures such as pleural drainage placement, image-guided percutaneous procedures, and endoscopic procedures. Surgical treatment includes more aggressive approaches such as thoracotomy and / or laparotomy, and can be performed at the start of fistula management or in the event of failure of conservative treatment. In these cases open thoracotomy is the most used approach according to the literature. METHOD: We present the case of a patient undergoing a postoperative right hepatectomy for hepatoarcinoma that complicates with an external biliary fistula and then with a pleuro-biliary fistula with empyema, in which thoracoscopy is used as part of the treatment. RESULT: the patient resolved the complication and the pleural drainage was removed 7 days later. CONCLUSION: thoracoscopy is a safe and effective approach in the treatment of this complication.

INTRODUCCION: La fístula biliopleural es una complicación poco frecuente que se origina por diversas causas, entre ellas, las resecciones hepáticas. No existe consenso acerca de cómo manejarlas. Existe 2 tipos de tratamiento: el quirúrgico y el conservador. Ambos pueden combinarse. El último implica la utilizacion de procedimientos quirúrgicos menores tales como la colocación de un tubo de drenaje pleural, drenajes percutáneos bajo guía imagenológica y procedimientos endoscópicos. El tratamiento quirúrgico incluye abordajes más agresivos como la toracotomía y/o laparotomía, y puede realizarse al inicio del manejo de la fístula o ante la falla del tratamiento conservador. En estos casos la toracotomia abierta es el abordaje más utilizado según la literatura, sin mencionar a la videotoracoscopia. METODO: Presentamos el caso de un paciente cursando un posoperatorio de hepatectomía derecha por hepatoarcinoma que complica con una fístula biliar externa y luego con una fístula biliopleural complicada con empiema, en el cual se utiliza la toracoscopía como parte del tratamiento. RESULTADO: el paciente resolvió la complicación y se extrajo el drenaje pleural 7 días después. CONCLUSION: la toracoscopía es un abordaje seguro y efectivo en el tratamiento de esta complicación.

Video-assisted thoracoscopic apicoposterior segmentectomy.

Anatomic segmentectomy is a form of sublobar resection that can be both diagnostic and therapeutic in the context of an indeterminate pulmonary nodule, suspected metastasis, or small peripheral cancer.  This video tutorial demonstrates our technique for an apicoposterior anatomical segmentectomy performed by video-assisted thoracoscopy, using two ports, for resection of an undiagnosed pulmonary nodule. The steps performed by the surgical team are shown, and we pay particular attention to the recognition of vascular anatomy. To perform this type of sublobar resection, it is necessary to understand both the normal anatomy and the different variants.  This tutorial will provide a thorough grounding in the anatomy of the apicoposterior segment as well as demonstrating the optimal approach for this type of resection.

VATS parathyroidectomy for primary hyperparathyroidism.

Mediastinal ectopic parathyroid glands are uncommon. Traditionally, median sternotomies were performed to treat this type of lesion, resulting in a long, painful postoperative period and poor aesthetic results. With the advent of video-assisted thoracoscopic surgery, procedures were performed more frequently by this route with the same surgical and oncological results as those achieved with conventional surgery. The introduction of more sophisticated imaging studies, such as computed tomography, computed tomography-technetium-99m sestamibi scintigraphy, and single-photon emission computed tomography, facilitated identification of the exact location of the lesion. Video-assisted thoracoscopy became a safe approach and the treatment of choice for resection.

VATS tracheal resection and reconstruction.

Tracheal resection followed by reconstruction is one of the most difficult procedures in thoracic surgery. Intrathoracic tracheal injuries were usually treated by sternotomy, thoracotomy, or a combination of these techniques. In the last decade, minimally invasive surgical techniques have become an innovative trend in the treatment of thoracic tracheal conditions. Recent authors have proven the feasibility and safety of tracheal operations using video-assisted thoracoscopic surgery (VATS). This video tutorial demonstrates our technique for intrathoracic tracheal resection performed by VATS, using 2 ports, for the resection of postintubation stenosis. We show the steps performed by the surgical team and pay special attention to the maneuvers needed to operate with greater safety and achieve a tension-free reconstruction. This tutorial provides a method for treating this type of tracheal injury. It is of special interest for surgeons who specialize in the airway.

Efficacy and reproducibility of lymphatics mapping technique with sentinel lymph node biopsy in melanoma.

INTRODUCTION: The study of the Sentinel Lymph Node (SLN) in Melanoma is a procedure that aims the identification of the first node to which the affected cutaneous sector drains in order to avoid unnecessary lymphadenectomies. The present study documents the frequency of identification of SLN; the relationship between positive SLN (PSLN) and recurrence, between the Breslow index (BI) and PSLN, and between BI and disease recurrence. METHOD: We analyzed the records of 148 patients with melanoma stages I and II undergoing lymphatic mapping and GC biopsy from 1999 to 2017 in a third level institution in Córdoba, Argentina. We performed preoperative lympho centellography, lymphatic mapping with combined technique and SLN biopsy. Postoperative controls were established in order to detect recurrences. RESULTS: SLN was identified in 145 patients (97.9%), being positive in 25 cases (17.2%). Recurrence was detected in 10 (8.3%) patients with negative SLN (NSLN), and in 2 (9.09%) with PSLN (p = 0.188). The median BI was 2 mm in PCG patients and 1.2 mm in GCN patients (p = 0.002). The mean BI in patients with recurrence was 2.77 mm, and 2.01 mm in those who did not show relapse (p = 0.311). CONCLUSIONS: The combined technique allows a high GC identification rate. A greater tendency to recurrence was observed in the presence of CPG. A statistically significant relationship between GCP and IB was found. The GC technique is effective and replicable in our environment.

INTRODUCCIÓN: El estudio del ganglio centinela (GC) en el melanoma maligno es un procedimiento que busca la identificación del primer ganglio al cual drena el sector cutáneo comprometido a fin de evitar linfadenectomías innecesarias. El presente estudio documenta la frecuencia de identificación del GC y la relación entre GC positivo (GCP) y recurrencia, entre el índice de Breslow (IB) y GCP, y entre el IB y la recurrencia de la enfermedad. MÉTODO: Se analizaron los registros de 148 pacientes con melanoma maligno en estadios I y II sometidos a mapeo linfático y biopsia de GC desde 1999 hasta 2017 en una institución de tercer nivel de Córdoba, Argentina. Se realizaron linfocentellografía preoperatoria, mapeo linfático con técnica combinada y biopsia de GC. Se establecieron controles posoperatorios reglados a fin de detectar recurrencias. RESULTADOS: Se identificó el GC en 145 pacientes (97.9%) y resultó positivo en 22 (17.2%). Se detectó recurrencia en 10 pacientes (8.3%) con GC negativo (GCN), y en 2 (9.09%) con GCP (p = 0.188). La mediana del IB fue de 2 mm en los pacientes con GCP y de 1.2 mm en los pacientes con GCN (p = 0.002). La media del IB en los pacientes con recurrencia fue de 2.77 mm, y en los que no mostraron recaída fue de 2.01 mm (p = 0.311). CONCLUSIONES: La técnica combinada permite una alta tasa de identificación del GC. Se observó una mayor tendencia a la recurrencia en presencia de GCP. Se comprobó una relación estadísticamente significativa entre GCP e IB. La técnica del GC es efectiva y replicable en nuestro medio.

Low prevalence of relevant associated articular lesions in patients with acute III-VI acromioclavicular joint injuries.

PURPOSE: To define the prevalence of associated articular injuries in patients with severe (Rockwood's III-VI) acute acromioclavicular joint injuries and to find out how many of these were associated with the traumatic event and required surgical treatment. METHODS: Retrospective observational multicentric study performed in ten centres included patients who required surgery for acute acromioclavicular joint injuries between 2010 and 2017. The inclusion criteria were: presence of an acute acromioclavicular joint injury (grades III-IV-V-VI) and surgical treatment within 3 weeks of injury that included a full arthroscopic evaluation of the shoulder. Basic epidemiological data, severity of the original injury, prelesional sport level and prelesional work site requirements were recorded. The presence of intraarticular glenohumeral lesions and information of their characteristics, treatment, and whether each lesion was considered acute or pre-existing was also recorded. RESULTS: Two-hundred one subjects [mean (SD) age 36.7 (11.7) years] with acute acromioclavicular joint injuries (110 Rockwood type III, 34 type IV, 56 type V and 1 type VI) fulfilled the inclusion criteria. A total of 28 (13.9%) associated articular lesions were found. These lesions were more often found in grade IV injuries (26.5% in grade IV vs 11.4% in grade III, p = 0.037) and presented in males (18.7% in males vs 4% in females, p = 0.015). Age, laterality, sport level or work requirements did not affect the prevalence of associated lesions. Twelve were rotator cuff tears (6 PASTA lesions, 3 partial supscapularis tears, 2 bursal supraspinatus tears and 1 full-thickness supraspinatus tear), 16 were labral tears (9 anterior, 1 posteroinferior and 6 SLAP). Only 14 (50% of lesions, 7% of total subjects) were considered acute and all but one (an SLAP type 2 tear) required further surgical attention. Most pre-existing lesions were left untreated (n = 7) or managed with minimal debridement (n = 6), and only two required further surgery. The prevalence of associated lesions that required surgical management was 7.46%. CONCLUSIONS: The prevalence of relevant associated lesions in subjects with acute grade III to VI ACJI is relatively low. Only 14% of subjects have an associated lesion and only half of these required further surgical attention. LEVEL OF EVIDENCE: Retrospective case series, level IV.

Biomechanical analysis of acromioclavicular joint dislocation repair using coracoclavicular suspension devices in two different configurations.

BACKGROUND: The best treatment option for some acromioclavicular (AC) joint dislocations is controversial. For this reason, the aim of this study was to evaluate the vertical biomechanical behavior of two techniques for the anatomic repair of coracoclavicular (CC) ligaments after an AC injury. MATERIALS AND METHODS: Eighteen human cadaveric shoulders in which repair using a coracoclavicular suspension device was initiated after injury to the acromioclavicular joint were included in the study. Three groups were formed; group I (n = 6): control; group II (n = 6): repair with a double tunnel in the clavicle and in the coracoid (with two CC suspension devices); group III (n = 6): repair in a "V" configuration with two tunnels in the clavicle and one in the coracoid (with one CC suspension device). The biomechanical study was performed with a universal testing machine (Electro Puls 3000, Instron, Boulder, MA, USA), with the clamping jaws set in a vertical position. The force required for acromioclavicular reconstruction system failure was analyzed for each cadaveric piece. RESULTS: Group I reached a maximum force to failure of 635.59 N (mean 444.0 N). The corresponding force was 939.37 N (mean 495.6 N) for group II and 533.11 N (mean 343.9 N) for group III. A comparison of the three groups did not find any significant difference despite the loss of resistance presented by group III. CONCLUSION: Anatomic repair of coracoclavicular ligaments with a double system (double tunnel in the clavicle and in the coracoid) permits vertical translation that is more like that of the acromioclavicular joint. Acromioclavicular repair in a "V" configuration does not seem to be biomechanically sufficient.

Nuevos datos sobre el Gabinete de Radiología en el Hospital Naval de San Carlos (1896-1920)

En el presente artículo, comentamos ciertos aspectos inéditos acerca del Gabinete de Radiología del Hospital Naval de San Carlos, centrados en el periodo comprendido entre 1896 y 1921. El escrito está basado principalmente en los documentos encontrados como consecuencia de la investigación bibliográfica y documental llevada a cabo en diversas bibliotecas de la Armada, del Archivo Nacional Don Alvaro de Bazán de El Viso del Marqués (Ciudad Real), de la Biblioteca Nacional y del Archivo General Militar de Segovia. El trabajo ha sido efectuado con motivo del Centenario de la creación de los Gabinetes de Radiología en los hospitales de la Armada, que tuvo lugar en Noviembre de 1897 (AU)