ABSTRACT
The aim of this study was to investigate the effect of a probiotic in preventing infections after third molar surgery. Thirty-eight patients were consecutively enrolled to a double-blind randomised placebo-controlled trial. Patients were asked to take one tablet two times a day containing a mixture of Levilactobacillus brevis CECT7480 (KABP-052) and Lactoplantibacillus plantarum CECT7481 (KABP-051) or placebo for the first post-intervention week. The primary outcome was the postoperative infection rate. Secondary outcomes included swelling, eating difficulties and postoperative pain recorded by the patient using a visual analogue scale (VAS) during the first postoperative week. No statistically significant difference in the infection rate between the groups was found; with only three cases of infections reported (one in the probiotic group and two in the placebo group) on the first week. Compared to placebo, treatment with the probiotic showed a significantly higher reduction in pain and eating difficulties scores at 5, 6 and 7 days post-surgery. Swelling values were not significantly different between the groups at any time point. The findings of this pilot study justify a larger study to clarify the possible role of these bacterial strains on the post-operative pain management following third molar surgery.
Subject(s)
Molar, Third/surgery , Pain, Postoperative/prevention & control , Probiotics/therapeutic use , Adolescent , Double-Blind Method , Female , Humans , Lactobacillus , Male , Pain, Postoperative/etiology , Pain, Postoperative/physiopathology , Pilot Projects , Surgical Wound Infection/etiology , Surgical Wound Infection/prevention & control , Tooth Extraction/adverse effects , Young AdultABSTRACT
INTRODUCTION: Ageing induces changes in gut microbiota that may affect the quality of life. In this work we analyze the effect of Lactobacillus plantarum CECT 7315/7316 on the regulation of intestinal transit and on nutritional status. METHODS: We carried out a double-blind, randomized and controlled by placebo clinical trial. We evaluated the evolution of the weekly defecation frequency and blood levels of total proteins, albumin, cholesterol and reactive C-protein. RESULTS: Lactobacillus plantarum CECT 7315/7316 helps to regulate intestinal transit and improves the nutritional status in elderly. CONCLUSIONS: Consumption of functional foods containing L. plantarum CECT 7315/7316 improves the quality of life in elderly subjects.
Subject(s)
Lactobacillus plantarum , Probiotics/therapeutic use , Aged , Aged, 80 and over , Female , Gastrointestinal Transit , Health Status , Humans , Male , Nutritional Status , Quality of LifeABSTRACT
Fundamentos: Con la edad avanzada se producen cambios en la microflora intestinal que pueden afectar alestado de salud general. En este trabajo analizamos el efecto de Lactobacillus plantarum CECT 7315/7316 sobre la regulación del tránsito intestinal y el estado nutricional. Métodos: Hemos realizado un estudio clínico doble ciego, controlado por placebo y aleatorizado. Hemos evaluado la evolución de la frecuencia de defecación semana ly los niveles en sangre de proteínas totales, albúmina, colesterol y proteína C-reactiva .Resultados: Lactobacillus plantarum CECT 7315/7316ayuda a regular el tránsito intestinal y mejora el estado nutricional en personas mayores. Conclusiones: El consumo de productos funcionales que contengan L. plantarum CECT 7315/7316 mejora la calidad de vida de personas de la tercera edad (AU)
Introduction: Ageing induces changes in gut microbiota that may affect the quality of life. In this work we analyze the effect of Lactobacillus plantarum CECT7315/7316 on the regulation of intestinal transit and on nutritional status. Methods: We carried out a double-blind, randomized and controlled by placebo clinical trial. We evaluated the evolution of the weekly defecation frequency and blood levels of total proteins, albumin, cholesterol and reactive C-protein. Results: Lactobacillus plantarum CECT 7315/7316 helps to regulate intestinal transit and improves the nutritional status in elderly. Conclusions: Consumption of functional foods containingL. plantarum CECT 7315/7316 improves the quality of life in elderly subjects (AU)
