An intracranial carcinoma in a Mexican woman with Bloom syndrome.

An intracranial cell squamous carcinoma was found in a 27-year-old Mexican woman with Bloom syndrome (BS), including growth retardation, sun-sensitive telangiectatic erythema, defective immunity, and increased number of mitotic chiasmata and sister chromatid exchanges. The tumour, probably originating from the inner or middle ear epithelium, was resected but the patient died a few days after surgery. There was no parental consanguinity nor Jewish or European ancestry for at least five generations; in fact, her parents were mostly indigenous people. This case represents an undescribed intracranial malignancy in BS and the third Mexican BS patient reported. The typical BS phenotype in a woman with pigmented skin challenges the contention that pigmented females are less severely affected.

Tratamiento de ulceraciones en tejidos blandos con difenilhidantoinato topico. / Treatment of soft tissue ulcers with topic diphenylhydantoin

El tratamiento de ulceraciones en tejidos blandos, en especial las lesiones cronicas de extremidades inferiores, son de dificil manejo. Para evaluar la actividad del difenilhidantoinato topico en este tipo de afecciones, 20 pacientes con diferentes lesiones ulcerativas de tejidos blandos fueron tratados diariamente y sus resultados conparados com un grupo control. El grupo tratado curo en 21 dias como promedio, comparado con 45 que registro el grupo control. Asimismo, en el grupo al que se aplico polvo de difenilhidantoinato se observo rapida mejoria de la infeccion bacteriana y en algunos casos hipergranulacion al utilizar el polvo durante periodos prolongados