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1.
J Matern Fetal Neonatal Med ; 34(2): 267-273, 2021 Jan.
Article in English | MEDLINE | ID: mdl-30957602

ABSTRACT

Objective: To evaluate the efficacy and safety of amniopatch in pregnancies associated with spontaneous preterm premature rupture of fetal membranes (PPROM).Methods: A randomized controlled trial that involved 100 women diagnosed with PPROM between 24 and 34 weeks of gestational age. Participants were randomized equally into two groups. Group I in which amniopatch was done in addition to the routine management. Group II was treated with routine management including antibiotics and corticosteroids.Results: Amniopatch was successful in complete sealing of the membrane defect in 6/50 (12%) of women while none the control group have undergone similar sealing (p = .0144, RR = 0.88). Women in the amniopatch group showed a significant increase of AFI compared to controls (12 versus 0, p = .0001, RR = 0.56).Conclusion: The amniopatch procedure is a successful technique that safely enhances sealing of fetal membranes and restore the AFI.Clinical trial registration: NCT03473210SynopsisThe amniopatch procedure is a successful technique that could be done safely to enhance sealing the fetal membranes and restoring the AFI after PPROM.


Subject(s)
Fetal Membranes, Premature Rupture , Adrenal Cortex Hormones , Extraembryonic Membranes , Female , Gestational Age , Humans , Infant, Newborn , Pregnancy
2.
J Gynecol Obstet Hum Reprod ; 50(4): 101875, 2021 Apr.
Article in English | MEDLINE | ID: mdl-32687890

ABSTRACT

OBJECTIVE: The study objective is to evaluate the benefits of using ultrasound guidance during insertion of Intrauterine device IUD in women with retroverted flexed RVF uteri. STUDY DESIGN: A randomized controlled trial conducted on 400 women with RVF uteri eligible for IUD insertion. They were randomly divided into 2 groups. Group 1 underwent IUD insertion under ultrasound guidance while in group 2 no ultrasound guidance was used. The primary outcome measure was the(Visual Analogue Scale) VAS pain score reported by the women during insertion. Other outcome included easiness of insertion, the procedure time and occurrence of complications as nausea, vomiting, abdominal cramps, failure of insertion, uterine perforation and bleeding. RESULTS: The VAS pain score was significantly lower (2.36 ± 1.77 vs. 4.74 ± 2.35, p < 0.001), the insertion was much easier (score 4.0 ± 0.9 vs. 2.5 ± 1.27, p < 0.001) and the time needed for the procedure was significantly shorter (5.82 ± 2.56 vs. 9.4 ± 4.99 min, p < 0.001) in women within the ultrasound guided group when compared to control group. The total rate of complications was significantly lower (6 vs. 16 %, p 0.001) especially bleeding (2 vs. 9%, p = 0.002), abdominal cramps (10.5 vs. 28 %, p 0.012) and failure of the procedure (0 vs. 3%, p = 005) in ultrasound guided group women when compared to control. CONCLUSION: Insertion of Intrauterine device IUD under ultrasound guidance in women with Retroverted flexed RVF uterus easier and less painful than the blind standard technique.


Subject(s)
Intrauterine Devices , Pain Measurement/methods , Pain, Procedural/diagnosis , Ultrasonography, Interventional , Uterine Retroversion , Adult , Colic/etiology , Female , Humans , Nausea/etiology , Pain, Procedural/etiology , Prosthesis Implantation/adverse effects , Prosthesis Implantation/methods , Uterine Hemorrhage/etiology , Uterine Perforation/etiology , Vomiting/etiology
3.
Int J Gynaecol Obstet ; 148(2): 219-224, 2020 Feb.
Article in English | MEDLINE | ID: mdl-31755559

ABSTRACT

OBJECTIVE: To assess the effectiveness of prophylactic bilateral uterine artery ligation (BUAL) in reducing the incidence of postpartum hemorrhage (PPH) during cesarean delivery among women at risk of uterine atony. METHODS: A randomized clinical trial at Cairo University Maternity Hospital, Egypt, from December 2017 to December 2018. Women at risk of uterine atony undergoing scheduled or emergency cesarean were randomized to two groups. In the BUAL group, women underwent BUAL before placental delivery; in the control group, women had cesarean delivery without BUAL. The primary outcome was the estimated blood loss during cesarean. RESULTS: Intraoperative blood loss during cesarean was significantly lower in the BUAL group than in the control group (523.4 ± 41.0 vs 619.6 ± 36.1 mL; P=0.003). Blood loss in the first 6 hours after cesarean was also significantly lower in the BUAL group than in the control group (246.1 ± 21.4 vs 326.1 ± 18.5 mL; P=0.006). There was no difference in operative time between the two groups (52.1 ± 6.1 vs 52.2 ± 6.8, P=0.880). CONCLUSION: BUAL during cesarean was found to be an effective method for decreasing blood loss during and after cesarean delivery among women at risk of uterine atony and subsequent PPH. CLINICALTRIALS.GOV: NCT03591679.


Subject(s)
Cesarean Section/methods , Postpartum Hemorrhage/prevention & control , Uterine Artery/surgery , Adult , Blood Loss, Surgical/statistics & numerical data , Egypt , Female , Humans , Ligation/methods , Operative Time , Postpartum Hemorrhage/etiology , Pregnancy , Uterine Inertia/physiopathology , Young Adult
4.
Int J Gynaecol Obstet ; 148(2): 238-242, 2020 Feb.
Article in English | MEDLINE | ID: mdl-31736069

ABSTRACT

OBJECTIVE: To compare effectiveness and safety of carbetocin and misoprostol for prevention of postpartum hemorrhage (PPH) among low-risk women. METHODS: Randomized controlled trial among 150 pregnant women with low risk of PPH admitted for vaginal delivery at Kasr Al Ainy Hospital, Cairo, Egypt, between July 2018 and May 2019. Participants were assigned to two groups by a web-based randomization system ensuring allocation concealment. After neonatal delivery, the carbetocin group received one ampoule of carbetocin (100 µg/mL) intravenously and the misoprostol group received two rectal tablets of misoprostol (800 µg) for active management of the third stage. Blood pressure, blood loss, and hemoglobin levels were monitored. The primary outcome measure was need for additional uterotonic drugs. RESULTS: The carbetocin group had significantly less blood loss (P<0.001), shorter third stage (P<0.001), and less need for additional uterotonics (P=0.013) or uterine massage (P=0.007). The two drugs were hemodynamically safe. Hemoglobin levels after delivery were comparable in the two groups (P=0.475). Adverse effects were more common in the misoprostol group (P<0.001). CONCLUSION: Among low-risk women, carbetocin seems to be a better alternative to misoprostol for active management of the third stage of labor; it reduced blood loss and use of additional uterotonic drugs. CLINICALTRIALS.GOV: NCT03556852.


Subject(s)
Misoprostol/administration & dosage , Oxytocics/administration & dosage , Oxytocin/analogs & derivatives , Postpartum Hemorrhage/prevention & control , Administration, Oral , Administration, Rectal , Adult , Egypt , Female , Humans , Labor Stage, Third/drug effects , Oxytocin/administration & dosage , Pregnancy
5.
Gynecol Endocrinol ; 36(8): 728-733, 2020 Aug.
Article in English | MEDLINE | ID: mdl-31870186

ABSTRACT

The aim of our study was to assess the value of serum AMH in prediction of metaphase II oocytes in poor responders. We performed a prospective cohort study included 206 poor responders candidate for ICSI using antagonist protocol. They were classified into 3 groups. Group I included 50 women with AMH < 0.3 ng/ml, group II included 85 women with AMH 0.3-0.7 ng/ml and group III included 71 women with AMH > 0.7-1.0 ng/ml. The primary outcome parameter was the number of MII oocytes. There was a highly significant difference between the study groups regarding E2 at triggering (481.41 ± 222.653, 648.17 ± 264.353 and 728.74 ± 305.412 respectively, number of oocyte retrieved (2.37 ± 1.178, 3.38 ± 1.622 and 3.80 ± 1.427 respectively), number of MII oocytes (1.66 ± 1.039, 2.35 ± 1.171 and 2.61 ± 1.080 respectively), number of fertilized oocytes (1.39 ± 0.919, 1.91 ± 0.983 and 2.21 ± 0.937 respectively), , total number of embryos (1.34 ± 0.938, 1.76 ± 0.956 and 2.09 ± 0.907 respectively), clinical pregnancy rates (4.9 vs. 7.7 and 19.7% respectively). We concluded that AMH is a good predictor for number of MII oocytes in poor responders undergoing ICSI.


Subject(s)
Anti-Mullerian Hormone/blood , Hormone Antagonists/therapeutic use , Infertility/diagnosis , Oocytes/physiology , Ovulation Induction/methods , Sperm Injections, Intracytoplasmic , Adult , Cohort Studies , Embryo Transfer , Female , Fertilization in Vitro/methods , Hormone Antagonists/pharmacology , Humans , Infertility/genetics , Infertility/therapy , Metaphase/drug effects , Metaphase/physiology , Oocyte Retrieval/methods , Oocytes/drug effects , Oocytes/metabolism , Oogenesis/drug effects , Oogenesis/physiology , Pregnancy , Pregnancy Rate , Prognosis , Prospective Studies , Sperm Injections, Intracytoplasmic/methods , Treatment Outcome
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