Subject(s)
Humans , Female , Adult , Liposarcoma/diagnosis , Retroperitoneal Neoplasms/diagnosis , Neurofibromatosis 1/diagnosis , Fatal OutcomeABSTRACT
No disponible
Subject(s)
Humans , Male , Young Adult , Carbamazepine/adverse effects , Anticonvulsants/adverse effects , Nail Diseases/chemically induced , Carbamazepine/therapeutic use , Anticonvulsants/therapeutic use , Epilepsy/drug therapyABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Purpura/etiology , Antiphospholipid Syndrome/complications , Antiphospholipid Syndrome/diagnostic imaging , Antiphospholipid Syndrome/drug therapy , Antibodies, Antiphospholipid , Biopsy , Magnetic Resonance Spectroscopy , Anticoagulants/therapeutic useABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Edema/etiology , Hemangiosarcoma/diagnosis , Hemangiosarcoma/pathology , Head and Neck Neoplasms/diagnostic imaging , Neoplasm Recurrence, Local/complications , Face , Hemangiosarcoma/therapy , Head and Neck Neoplasms/pathology , Edema/pathology , Biopsy , Face/pathology , Immunohistochemistry , Platelet Endothelial Cell Adhesion Molecule-1 , Antigens, CD34 , Paclitaxel/administration & dosage , Hemangiosarcoma/radiotherapyABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Granuloma Annulare/diagnosis , Takayasu Arteritis/complications , Vasculitis, Leukocytoclastic, Cutaneous/diagnosis , Biopsy , Diagnosis, Differential , Granuloma Annulare/drug therapy , Granuloma Annulare/pathology , Methotrexate/therapeutic use , Methylprednisolone/therapeutic use , Mycosis Fungoides/diagnosis , Prednisone/therapeutic use , ElbowSubject(s)
Granuloma Annulare/diagnosis , Takayasu Arteritis/complications , Biopsy , Diagnosis, Differential , Elbow , Female , Granuloma Annulare/complications , Granuloma Annulare/drug therapy , Granuloma Annulare/pathology , Humans , Methotrexate/therapeutic use , Methylprednisolone/therapeutic use , Middle Aged , Mycosis Fungoides/diagnosis , Prednisone/therapeutic use , Vasculitis, Leukocytoclastic, Cutaneous/diagnosisABSTRACT
La dermatosis caracterizada por eosinofilia tisular que aparece en el contexto de un trastorno hematológico se conoce con el nombre de dermatosis eosinofílica asociada a proceso hematológico, siendo el más frecuente de todos la leucemia linfática crónica. Se trata de una entidad poco frecuente que tiene un amplio espectro morfológico, desde pápulas, nódulos eritematosos o ampollas que simulan picaduras de artrópodo hasta la formación de verdaderas placas de tamaño variable y en las que la histología se caracteriza por la presencia de abundantes eosinófilos. Presentamos 4 nuevos casos diagnosticados en nuestro hospital en los últimos 7 años, 3 de ellos asociados a una leucemia linfática crónica y un cuarto caso asociado a una micosis fungoide. La importancia de conocer esta dermatosis radica en el hecho de que puede indicar una progresión de la enfermedad de base, y así fue en 3 de nuestros pacientes (AU)
Dermatosis characterized by tissue eosinophilia arising in the context of hematologic disease is known as eosinophilic dermatosis of hematologic malignancy. The most commonly associated malignancy is chronic lymphocytic leukemia. Eosinophilic dermatosis of hematologic malignancy is a rare condition with a wide variety of clinical presentations, ranging from papules, erythematous nodules, or blisters that simulate arthropod bites, to the formation of true plaques of differing sizes. Histology reveals the presence of abundant eosinophils. We present 4 new cases seen in Hospital Arnau de Vilanova, Valencia, during the past 7 years. Three of these cases were associated with chronic lymphocytic leukemia and 1 with mycosis fungoides. It is important to recognize this dermatosis as it can indicate progression of the underlying disease, as was the case in 3 of our patients (AU)
Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Eosinophilia/complications , Skin Diseases/complications , Leukemia, Lymphocytic, Chronic, B-Cell/complications , Mycosis Fungoides/complications , Diagnosis, Differential , Adrenal Cortex Hormones/therapeutic use , Administration, Topical , Prednisone/therapeutic useABSTRACT
Dermatosis characterized by tissue eosinophilia arising in the context of hematologic disease is known as eosinophilic dermatosis of hematologic malignancy. The most commonly associated malignancy is chronic lymphocytic leukemia. Eosinophilic dermatosis of hematologic malignancy is a rare condition with a wide variety of clinical presentations, ranging from papules, erythematous nodules, or blisters that simulate arthropod bites, to the formation of true plaques of differing sizes. Histology reveals the presence of abundant eosinophils. We present 4 new cases seen in Hospital Arnau de Vilanova, Valencia, during the past 7 years. Three of these cases were associated with chronic lymphocytic leukemia and 1 with mycosis fungoides. It is important to recognize this dermatosis as it can indicate progression of the underlying disease, as was the case in 3 of our patients.
Subject(s)
Dermatitis/etiology , Eosinophilia/etiology , Leukemia, Lymphocytic, Chronic, B-Cell/complications , Mycosis Fungoides/complications , Paraneoplastic Syndromes/etiology , Adrenal Cortex Hormones/therapeutic use , Aged , Aged, 80 and over , Antineoplastic Agents/adverse effects , Antineoplastic Agents/therapeutic use , Bexarotene , Dermatitis/diagnosis , Dermatitis/drug therapy , Diagnosis, Differential , Disease Progression , Eosinophilia/diagnosis , Eosinophilia/drug therapy , Female , Humans , Insect Bites and Stings/diagnosis , Male , Middle Aged , Mycosis Fungoides/drug therapy , Paraneoplastic Syndromes/diagnosis , Paraneoplastic Syndromes/drug therapy , Retrospective Studies , Tetrahydronaphthalenes/adverse effects , Tetrahydronaphthalenes/therapeutic useSubject(s)
Adnexal Diseases/pathology , Skin Neoplasms/diagnosis , Aged , Female , Humans , Male , Skin Neoplasms/pathologyABSTRACT
No disponible
Subject(s)
Humans , Female , Aged , Hemangiosarcoma/etiology , Breast Neoplasms/radiotherapy , Radiodermatitis/diagnosis , Radiation Injuries/diagnosisSubject(s)
Breast Neoplasms/etiology , Hemangiosarcoma/etiology , Neoplasms, Radiation-Induced/etiology , Neoplasms, Second Primary/etiology , Radiotherapy, Adjuvant/adverse effects , Skin Neoplasms/etiology , Aged , Breast Neoplasms/diagnosis , Breast Neoplasms/drug therapy , Breast Neoplasms/pathology , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Carcinoma, Ductal, Breast/radiotherapy , Carcinoma, Ductal, Breast/surgery , Combined Modality Therapy , Female , Hemangiosarcoma/diagnosis , Hemangiosarcoma/drug therapy , Hemangiosarcoma/pathology , Humans , Mastectomy, Segmental , Mastectomy, Simple , Neoplasms, Radiation-Induced/diagnosis , Neoplasms, Radiation-Induced/drug therapy , Neoplasms, Radiation-Induced/pathology , Neoplasms, Second Primary/diagnosis , Neoplasms, Second Primary/drug therapy , Neoplasms, Second Primary/pathology , Prognosis , Skin Neoplasms/diagnosis , Skin Neoplasms/drug therapy , Skin Neoplasms/pathology , Time FactorsABSTRACT
La enfermedad de Still del adulto es una enfermedad sistémica, poco frecuente, de etiología desconocida y que suele afectar a adultos jóvenes. Se caracteriza por la asociación de artralgias, fiebre alta en picos y un exantema característico. Las lesiones cutáneas están formadas por máculas eritematosas de color salmón, de aspecto urticariforme y que se distribuyen principalmente en el tronco y la raíz de extremidades. Estas lesiones son asintomáticas y aparecen en forma de erupción característicamente transitoria, de aparición vespertina y resolución posterior fugaz, siguiendo un curso paralelo al de la fiebre. Desde el punto de vista histológico se caracteriza por un infiltrado inflamatorio dérmico perivascular compuesto principalmente de linfocitos y con presencia de neutrófilos. El factor reumatoide y los anticuerpos antinucleares son negativos y en el hemograma se observa leucocitosis con neutrofilia. Otros posibles hallazgos en la enfermedad de Still del adulto son úlceras de garganta, linfadenopatías, esplenomagalia o disfunciónhepática entre otras. Presentamos los casos de cuatro mujeres con enfermedad de Still del adulto y describimos sus lesiones cutáneas, afectación sistémica, características histológicas y su evolución (AU)
Adult onset Stills disease (AOSD) is a rare systemic illness of unknown aetiology and which usually affects young adults. It is characterised by arthralgia,high peaking temperatures and a characteristic exanthema. Cutaneous lesions are salmon coloured erythematous urticariform macula found mainly on the trunk and extremities. These lesions are symptom free and appear as typically transitory evening eruptions with posterior fleeting resolution and follow a parallel course to the high temperature. Histologically, they show a perivascular inflammatory dermic infiltrate with lymphocitic predominance and containing some neutrophils. Rheumatoid factors and antinuclear antibodies are negative and leucocytosis with neutrophilia is seenon blood analysis. Other possible findings in AOSD are sore throat, lymphoadenopathies, splenomegalia or liver dysfunction, among others.AOSD in 4 females is presented describing cutaneous lesions, systemic involvement, histological results and evolution (AU)
Subject(s)
Humans , Female , Adult , Middle Aged , Still's Disease, Adult-Onset/diagnosis , Exanthema/etiology , Arthralgia/etiology , Fever/etiology , Diabetes Mellitus , Prednisone/therapeutic useABSTRACT
La enfermedad de Still del adulto es una enfermedad sistémica, poco frecuente, de etiología desconocida y que suele afectar a adultos jóvenes. Se caracterizapor la asociación de artralgias, fiebre alta en picos y un exantema característico. Las lesiones cutáneas están formadas por máculas eritematosas decolor salmón, de aspecto urticariforme y que se distribuyen principalmente en el tronco y la raíz de extremidades. Estas lesiones son asintomáticas y aparecenen forma de una erupción característicamente transitoria, de aparición vespertina y resolución fugaz, siguiendo un curso paralelo al de la fiebre. Desdeel punto de vista histológico se caracteriza por un infiltrado inflamatorio dérmico perivascular compuesto principalmente de linfocitos y con presencia deneutrófilos. El factor reumatoide y los anticuerpos antinucleares son negativos y en el hemograma se observa leucocitosis con neutrofilia. Otros posibleshallazgos en la enfermedad de Still del adulto son úlceras en la garganta, linfadenopatías, esplenomegalia o disfunción hepática entre otras.Presentamos los casos de cuatro mujeres con enfermedad de Still del adulto y describimos sus lesiones cutáneas, afectación sistémica, característicashistológicas y su evolución (AU)
Adult onset Stills disease (AOSD) is a rare systemic illness of unknown aetiology and which usually affects young adults. It is characterised by arthralgia,high peaking temperatures and a characteristic exanthema. Cutaneous lesions are salmon coloured erythematous urticariform macula located mainly onthe trunk and extremities. These lesions are symptom free and appear as typically transitory evening eruptions with posterior fleeting resolution and followa parallel course to the fever. Histologically, they show a perivascular inflammatory dermic infiltrate with lymphocitic predominance and containing someneutrophils. Rheumatoid factors and antinuclear antibodies are negative and leucocytosis with neutrophilia is seen on blood analysis. Other possible findingsin AOSD are sore throat, lymphoadenopathies, splenomegalia or liver dysfunction, among others (AU)
Subject(s)
Humans , Female , Adult , Middle Aged , Still's Disease, Adult-Onset/diagnosis , Still's Disease, Adult-Onset/drug therapy , Still's Disease, Adult-Onset/pathology , Prednisone/therapeutic use , Adrenal Cortex HormonesABSTRACT
Ossifying fibromyxoid tumors (OFT) of soft parts are very rare neoplasms recently described by Enzinger et al. (1). They usually present as well-circumscribed, slow-growing, asymptomatic subcutaneous masses. A characteristic finding is a fibrous capsule and an incomplete peripheral shell of mature bone. Although most cases behave as benign tumors, a high rate of local recurrences have been described. We describe a 43-year-old male with a perianal subcutaneous tumor of 10 years evolution. The histopathology was compatible with OFT. Due to the subcutaneous location of OFT, both the dermatologist and dermatopathologist need to know about this rare tumor.
Subject(s)
Fibroma/pathology , Ossification, Heterotopic/pathology , Skin Neoplasms/pathology , Soft Tissue Neoplasms/pathology , Adult , Humans , MaleABSTRACT
The immunosuppressive effect of cyclosporine A (CsA) was studied in six pigs that underwent orthotopic liver transplant (OLT). The drug was administered i.v. in low doses (1.5-4 mg/Kg-1/12 h-1) and associated with wide spectrum antibiotics. The mean survival of the animals was 23.4 +/- 11.2 days. All animals had fever, jaundice and hypertrichosis, and the preoperative corporal weight remained constant. Liver abscesses by E. coli were common autopsy findings. Livers also presented biliary regeneration and cholestasis with a slight lymphocytic infiltration. OLT in pigs without immunosuppressive treatment causes and elevation in serum gamma-GTP, GOT, LDH, alkaline phosphatase and bilirubin. In the post-mortem findings, the livers did not present abscesses but evidenced intense atrophy with hepatocellular necrosis and abundant lymphocytic infiltration.
