Solitons in a nonlinear model of spin transport in helical molecules.

We study an effective integrable nonlinear model describing an electron moving along the axis of a deformable helical molecule. The helical conformation of dipoles in the molecular backbone induces an unconventional Rashba-like interaction that couples the electron spin with its linear momentum. In addition, a focusing nonlinearity arises from the electron-lattice interaction, enabling the formation of a variety of stable solitons such as bright solitons, breathers, and rogue waves. A thorough study of the soliton solutions for both focusing and defocusing nonlinear interaction is presented and discussed.

Clinical and pathologic features of patients with non-epithelial ovarian cancer: retrospective analysis of a single institution 15-year experience

Purpose. Non-epithelial ovarian cancers (NEOCs) are rare diseases. Despite their overall good prognosis, the best management and current prognostic factors remain unclear. The objective of our study was to assess the clinical and pathological features of NEOC patients treated in our institution in the last 15 years and to explore risk factors for relapse and survival. Methods/patients. All patients with a pathological diagnosis of NEOC referred to the medical oncology department at Hospital Universitario Virgen del Rocio between 1999 and 2014 were included. Demographics, tumor characteristics, treatment procedures, and clinical follow-up were retrospectively collected. Risk factors for disease-free survival (DFS) and overall survival (OS) were assessed. Results. Fifty-seven patients were included, 33 (58 %) had a sex cord-stromal tumor (SCST) and 24 (42 %) had a germ-cell tumor (GCT). Median age, non-conservative surgery rates and DFS were lower in the GCT cohort; however, salvage chemotherapy led to a high proportion of complete responses in this group translating into a 90 % 3-year OS rate in both NEOC subtypes. The only identified risk factors statistically significant were stage and tumour relapse that associated, respectively, with DFS (HR = 8.84; 95 % CI 1.85-42) and OS (HR = 11.02; 95 % CI 1.76-68.7). Conclusions. Despite their rarity, NEOCs remain a highly curable group of neoplasm. In our series, a more conservative treatment approach in ovarian GCTs revealed comparable OS outcomes to SCST. No new risk factors that would help in patient stratification were identified (AU)

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Clinical and pathologic features of patients with non-epithelial ovarian cancer: retrospective analysis of a single institution 15-year experience.

PURPOSE: Non-epithelial ovarian cancers (NEOCs) are rare diseases. Despite their overall good prognosis, the best management and current prognostic factors remain unclear. The objective of our study was to assess the clinical and pathological features of NEOC patients treated in our institution in the last 15 years and to explore risk factors for relapse and survival. METHODS/PATIENTS: All patients with a pathological diagnosis of NEOC referred to the medical oncology department at Hospital Universitario Virgen del Rocio between 1999 and 2014 were included. Demographics, tumor characteristics, treatment procedures, and clinical follow-up were retrospectively collected. Risk factors for disease-free survival (DFS) and overall survival (OS) were assessed. RESULTS: Fifty-seven patients were included, 33 (58 %) had a sex cord-stromal tumor (SCST) and 24 (42 %) had a germ-cell tumor (GCT). Median age, non-conservative surgery rates and DFS were lower in the GCT cohort; however, salvage chemotherapy led to a high proportion of complete responses in this group translating into a 90 % 3-year OS rate in both NEOC subtypes. The only identified risk factors statistically significant were stage and tumour relapse that associated, respectively, with DFS (HR = 8.84; 95 % CI 1.85-42) and OS (HR = 11.02; 95 % CI 1.76-68.7). CONCLUSIONS: Despite their rarity, NEOCs remain a highly curable group of neoplasm. In our series, a more conservative treatment approach in ovarian GCTs revealed comparable OS outcomes to SCST. No new risk factors that would help in patient stratification were identified.

Lump solitons in a higher-order nonlinear equation in 2+1 dimensions.

We propose and examine an integrable system of nonlinear equations that generalizes the nonlinear Schrödinger equation to 2+1 dimensions. This integrable system of equations is a promising starting point to elaborate more accurate models in nonlinear optics and molecular systems within the continuum limit. The Lax pair for the system is derived after applying the singular manifold method. We also present an iterative procedure to construct the solutions from a seed solution. Solutions with one-, two-, and three-lump solitons are thoroughly discussed.

Single trial P300 detection in children using expert knowledge and SOM.

Preliminary results of an automatic system for single trial P300 visual evoked potential events detection are presented. For each single trial P300, several candidate events were generated, and then filtered, using 3 wave features. The surviving candidate events were fed into a SOM-based classifier. A context filter was applied before the final output. No stationary condition of the P300 is involved in the algorithms. Recordings of 27 assessment sessions, each with 120 trials, were visually inspected by experts to identify and mark the P300 events, which was accomplished in about one third of the trials. The dataset was divided in training (18) and testing (9) subsets. The system identifies the initial and end times of the P300; it obtained a sensitivity of 53.9%, a specificity of 64.0% and an accuracy of 61.2% in the testing dataset.

A balanced sleep/wakefulness classification method based on actigraphic data in adolescents.

Several research groups have developed automated sleep-wakefulness classifiers for night wrist actigraphic (ACT) data. These classifiers tend to be unbalanced, with a tendency to overestimate the detection of sleep, at the expense of poorer detection of wakefulness. The reason for this is that the measure of success in previous works was the maximization of the overall accuracy, disregarding the balance between sensitivity and specificity. The databases were usually sleep recordings, hence the over-representation of sleep samples. In this work an Artificial Neural Network (ANN), sleep-wakefulness classifier is presented. ACT data was collected every minute. An 11-min moving window was used as observing frame for data analysis, as applied in previous sleep ACT studies. However, our feature set adds new variables such as the time of the day, the median and the median absolute deviation. Sleep and Wakefulness data were balanced to improve the system training. A comparison with previous studies can still be done, by choosing the point in the ROC curve associated with the corresponding data balance. Our results are compared with a polysomnogram-based hypnogram as golden standard, rendering an accuracy of 92.8%, a sensitivity of 97.6% and a specificity of 73.4%. Geometric mean between sensitivity and specificity is 84.9%.

Coenzyme Q10 stability in pediatric liquid oral dosage formulations

Objective: To study the stability of Coenzyme Q10 (CoQ10), used as therapeutic agent in treatment of cardiovascular and mitochondrial diseases, in three liquid formulations: two soybean oil solutions (50 mg/ml), one of them with the addition of vitamin E and an O/W emulsion (20 mg/ml) for pediatric use. Furthermore, optimize and validate a stabilityindicating HPLC method for the analysis of CoQ10 in the studied formulations. Method: All samples were stored at 25°C. CoQ10 content of each formulation was analyzed in duplicate using fast microbore high performance liquid chromatography (Micro HPLC) at 0, 3, 6, 15, 30, 60 and 110 days. Results: All formulations stayed stable at 25°C during the 110 days of the study. However, the oil solutions presented greater content variations through all the study period. Conclusions: The CoQ10 emulsion can be stored for at least 110 days at 25 °C and it has proven to be safer when narrow dose adjustment is required. The proposed analytical method was suitable for the study of stability of different formulations meeting the validation parameters according to international guidelines (AU)

Objetivo: Estudiar la estabilidad de Coenzima Q10 (CoQ10), utilizada como agente terapéutico en el tratamiento de enfermedades cardiovasculares y mitocondriales en 2 soluciones con aceite de soja como vehículo (50 mg/ml), una de ellas con el agregado de vitamina E y una emulsión O/W (20 mg/ml) para uso pediátrico. Asimismo, optimizar y validar un método indicativo de estabilidad por HPLC aplicado al análisis de CoQ10 en las respectivas formulaciones estudiadas. Método: Todas las muestras fueron almacenadas a temperatura ambiente (25 °C) y su contenido fue analizado utilizando Micro HPLC. Cada muestra fue analizada por duplicado a los 0, 3, 6, 15, 30, 60 y 110 días. Resultados: La coenzima Q10 se mantuvo estable en las formulaciones durante los 110 días a una temperatura de 25°C. Sin embargo, se detectó una mayor variación en las concentraciones obtenidas para las dos soluciones en aceite de soja. Conclusiones: La emulsión O/W de CoQ10 puede ser almacenada por al menos 110 días a 25°C y demostró ser más segura cuando se requiere ajustar la dosis. El método analítico propuesto fue adecuado para realizar el estudio de estabilidad de las distintas formulaciones cumpliendo con los parámetros de validación acorde a las guías internacionales (AU)

Coenzyme Q10 stability in pediatric liquid oral dosage formulations.

OBJECTIVE, To study the stability of Coenzyme Q10 (CoQ10), used as therapeutic agent in treatment of cardiovascular and mitochondrial diseases, in three liquid formulations: two soybean oil solutions (50 mg/ml), one of them with the addition of vitamin E and an O/W emulsion (20 mg/ml) for pediatric use. Furthermore, optimize and validate a stabilityindicating HPLC method for the analysis of CoQ10 in the studied formulations. METHOD, All samples were stored at 25°C. CoQ10 content of each formulation was analyzed in duplicate using fast microbore high performance liquid chromatography (Micro HPLC) at 0, 3, 6, 15, 30, 60 and 110 days. RESULTS, All formulations stayed stable at 25°C during the 110 days of the study. However, the oil solutions presented greater content variations through all the study period. CONCLUSIONS, The CoQ10 emulsion can be stored for at least 110 days at 25 °C and it has proven to be safer when narrow dose adjustment is required. The proposed analytical method was suitable for the study of stability of different formulations meeting the validation parameters according to international guidelines.

Fine mapping of 10q and 18q for familial Alzheimer's disease in Caribbean Hispanics.

Familial Alzheimer's disease (AD [MIM 104300]) has been a focus of intense investigation, primarily in Caucasian families from Europe and North America families. Although the late-onset form of familial AD, beginning after age 65 years, has been linked to regions on chromosomes 10q and 12p, the specific genetic variants have not yet been consistently identified. Using a unique cohort of families of Caribbean Hispanics ancestry, we screened the genome using 340 markers on 490 family members from 96 families with predominantly late-onset AD. We observed the strongest support for linkage on 18q (LOD=3.14). However, 17 additional markers (chromosomes 1-6, 8, 10, 12, and 14) exceeded a two-point LOD score of 1.0 under the affecteds-only autosomal dominant model or affected sibpair model. As we previously reported the fine-mapping effort on 12p showing modest evidence of linkage, we focused our fine-mapping efforts on two other candidate regions in the current report, namely 10q and 18q. We added 31 family members and eight additional Caribbean Hispanic families to fine map 10q and 18q. With additional microsatellite markers, the evidence for linkage for 18q strengthened near 112 cM, where the two-point LOD score for D18S541 was 3.37 and the highest NPL score in that region was 3.65 (P=0.000177). This narrow region contains a small number of genes expressed in the brain. However, at 10q (134-138 cM), the NPL score decreased from 3.15 (P=0.000486) to 2.1 (P=0.0218), but two broad peaks remained overlapping with previously reported peaks. Our results provide modest support for linkage on 10q and 12p in this cohort of Caribbean Hispanic families with familial Alzheimer's disease, and strong evidence for a new locus on 18q.

Power requirements for vibrotactile piezo-electric and electromechanical transducers.

Human-machine information transfer through tactile excitation has addressed new applications in virtual reality, robotics, telesurgery, sensory substitution and rehabilitation for the handicapped in the past few years. Power consumption is an important factor in the design of vibrotactile displays, because it affects energy needs and the size, weight, heat dissipation and cost of the associated electronics. An experimental study is presented on the power required to reach tactile thresholds in electromechanical and piezo-electric transducers. Three different waveforms are considered, with an excitatory period formed by a burst of rectangular 50% duty cycle pulses (R50), rectangular low duty cycle pulses (RLO) and sinusoidal pulses (SIN). Ten different pulse repetition periods (RPs) were considered in the range 1/550-1/25 s. The voltage and current waveforms applied to the transducers at sensation thresholds in a group of 12 healthy subjects were sampled and stored in a digital oscilloscope. The average power was determined for each subject, and differences of two orders of magnitude were measured between the electromechanical and the piezo-electric transducer power consumption. Results show that, for the electromechanical transducer, a smaller power consumption of 25 microW was determined for RP = 1/25 s and the RLO waveform. In the case of the piezo-electric transducer, power of 0.21 microW was determined for SIN excitation and RP = 1/250 s. These results show the advantages of reducing power requirements for vibrotactile displays, which can be optimised by the choice of appropriate types of transducer, excitatory waveforms and pulse repetition periods.

Genetic design of biologically inspired receptive fields for neural pattern recognition.

This paper proposes a new method for the design, through simulated evolution, of biologically inspired receptive fields in feedforward neural networks (NNs). The method is intended to enhance pattern recognition performance by creating new neural architectures specifically tuned for a particular pattern recognition problem. It proposes a combined neural architecture composed of two networks in cascade: a feature extraction network (FEN) followed by a neural classifier. The FEN is composed of several layers with receptive fields constructed by additive superposition of excitatory and inhibitory fields. A genetic algorithm (GA) is used to select receptive field parameters to improve classification performance. The parameters are receptive field size, orientation, and bias as well as the number of different receptive fields in each layer. Based on a random initial population where each individual represents a different neural architecture, the GA creates new enhanced individuals. The method is applied to handwritten digit classification and face recognition. In both problems, results show strong dependency between NN classification performance and receptive field architecture. GA selected parameters of the receptive fields produced improvements in the classification performance on the test set up to 90.8% for the problem of handwritten digit classification and up to 84.2% for the face recognition problem. On the same test sets, results were compared advantageously to standard feedforward multilayer perceptron (MLP) NNs where receptive fields are not explicitly defined. The MLP reached a maximum classification performance of 84.9% and 77.5% in both problems, respectively.

Polysomnographic pattern recognition for automated classification of sleep-waking states in infants.

A robust, automated pattern recognition system for polysomnography data targeted to the sleep-waking state and stage identification is presented. Five patterns were searched for: slow-delta and theta wave predominance in the background electro-encephalogram (EEG) activity; presence of sleep spindles in the EEG; presence of rapid eye movements in an electro-oculogram; and presence of muscle tone in an electromyogram. The performance of the automated system was measured indirectly by evaluating sleep staging, based on the experts' accepted methodology, to relate the detected patterns in infants over four months of post-term age. The set of sleep-waking classes included wakefulness, REM sleep and non-REM sleep stages I, II, and III-IV. Several noise and artifact rejection methods were implemented, including filters, fuzzy quality indices, windows of variable sizes and detectors of limb movements and wakefulness. Eleven polysomnographic recordings of healthy infants were studied. The ages of the subjects ranged from 6 to 13 months old. Six recordings counting 2665 epochs were included in the training set. Results on a test set (2,369 epochs from five recordings) show an overall agreement of 87.7% (kappa 0.840) between the automated system and the human expert. These results show significant improvements compared with previous work.

Chromosome-12 mapping of late-onset Alzheimer disease among Caribbean Hispanics.

Linkage to chromosome 12p for familial Alzheimer disease (AD) has been inconsistent. Using 35 markers near the centromere of chromosome 12, we investigated 79 Caribbean Hispanic families with AD. Two-point linkage analysis using affected sib pairs yielded LOD scores of 3.15 at D12S1623 and 1.43 at D12S1042. The LOD score at D12S1623 decreased to 1.62 in families with late-onset (age >65 years) AD (LOAD), but the LOD score at D12S1042 was unchanged. Among families negative for the apolipoprotein E (APOE-epsilon 4) allele, the LOD score for D12S1623 was lower (1.01), whereas that for D12S1042 increased to 1.73. Among families positive for the APOE-epsilon 4 allele, none of the LOD scores reached 1. Multipoint affected-relative-pair analysis showed peaks at D12S1623 (nonparametric linkage [NPL] score 1.52; P=.028) and near D12S1042, at D12S1057 (NPL score 1.57; P=.027). NPL scores for both D12S1623 and D12S1057 increased in families affected with LOAD, but, in APOE-epsilon 4-negative families, only scores for the region flanking D12S1623 remained elevated (NPL score 1.74; P=.013). This study of Caribbean Hispanics with familial AD extends and provides modest evidence of linkage to loci on chromosome 12p. Linkage varied by age at onset of AD and by the presence or absence of the APOE-epsilon 4 allele.

Dynamical properties of min-max networks.

In this paper we study the dynamical behavior of a class of neural networks where the local transition rules are max or min functions. We prove that sequential updates define dynamics which reach the equilibrium in O(n2) steps, where n is the size of the network. For synchronous updates the equilibrium is reached in O(n) steps. It is shown that the number of fixed points of the sequential update is at most n. Moreover, given a set of p < or = n vectors, we show how to build a network of size n such that all these vectors are fixed points.

[Vascular ectasias of the gastric antrum as the cause of chronic digestive hemorrhage. Presentation of a case]. / Ectasias vasculares del anatro gástrico como causa de sangramiento digestivo crónico. Presentación de un caso.

Digestive hemorrhages are one of the syndromes, that frequently attracts the attention of the gastroenterologist-endoscopist. Sometimes it's not evident during upper endoscopy study and course with a contrast radiological scan. In the last years a vascular pathology has been seen which is responsible of high digestive hemorrhages. It is manifested by melaena and is originated by vascular ectasias, which are vascular dilatations present in the stomach or right colon during various accompanying pathologies like hepatic cirrhosis with portal hypertension, cardiac valvulopaties, etc. Here we present a 61 year old woman with a history of chronic hepatopathy of cirrhotic type and imprecise etiology (diagnosed since 1983). Approximately two years ago (1996-1997) she has been presenting digestive hemorrhages and she has been transfused in different occasions because she had severe anemia. Diffuse vascular ectasias in the distal region of the antrum and in part of the gastric body were observed during duodenoscopy and colonoscopy with signs of active hemorrhage and similar non-bleeding lesions in the colon. Pyruvic transaminase was normal; HBV and HCV -markers were -negative. Ultrasound analysis was normal. The diagnosis at the discharge from Hospital was Diffuse Vascular Ectasias of the Gastric Antrum and part of the gastric body, caecum and right colon, secondary to hepatic cirrhosis. She was admitted again at the hospital because of new upper digestive hemorrhages and surgery was indicated. Gastric resection was performed with promising results. This case is analyzed and the pathology is results.

[Functional classification of the elderly in primary health care: proposed method]. / Clasificación funcional del anciano en atención primaria de salud: propuesta de un método.

OBJECTIVE: To develop a method of functional classification of the elderly (FCE) in Primary Health Care and to define the age limit for considering someone "a frail elderly person." DESIGN: A descriptive study in two phases: a) the method's design by means of "brainwriting" and b) the evaluation of the method in a descriptive crossover study. SETTING: A rural medical consulting-room. PATIENTS AND OTHER PARTICIPANTS: The research team, in the design of the method; and the elderly population attending for health care (n = 131), in the method's evaluation. MEASUREMENTS AND MAIN RESULTS: The FCE method was based on the Katz (IK) and Lawton-Brodie (IL-B) indices and classified the patients as independent and at different levels of disability. Urinary incontinence (UI) was excluded from the IK. 85.4% of the patients were independent, which bore relation to age (p < 0.001), but not to gender. When UI was included in the IK, the number of people classified as disabled increased by 32% (CI 95%, 23-41%) over when it was not included. Yet 80% of patients with UI were independent. No differences in the percentage of disabled patients were observed when the cut-off age for detecting disabled patients varied from 75 to 80. CONCLUSIONS: The inclusion of UI as a negative factor in the IK gives rise to overestimates of the number of disabled people. In our study the data suggested that the age for considering an elderly person as 'frail' should be 80.

Histopathologic and humoral study of Balb/c mice inoculated with BCG by different routes.

With the aim of determining the distribution and humoral immunogenicity of the bacillus Calmette-Guérin (BCG) administered by the oral (O), intravenous (IV) and subcutaneous (SC) routes, we studied 54 male Balb/c mice weighing 17-22 g that had been inoculated with BCG (10(6) CFU) by the O (n = 18), IV (n = 18) and SC (n = 18) routes. At weekly intervals we determined the distribution of the microorganism using histopathological techniques including Ziehl-Neelsen staining. Serum samples of the same animals were analyzed by ELISA and Western blot to determine the antibody response to the microorganism. In all groups, distinctive histopathologic lesions harboring the microorganism were found. Using the SC route the lesions were located at the inoculation site, whereas there was systemic dissemination with the O and IV routes, being more prominent with the latter. Anti-BCG antibodies were detected by ELISA in all groups; this response was more intense in the IV group, followed by the SC and O groups. In the Western blot analysis, reactivity against multiple bands and the predominant recognition of a 65 kd band in all groups was observed.

[The exhaustive geriatric evaluation in primary care: an assessment of its utility]. / Evaluación geriátrica exhaustiva en atención primaria: valoración de su utilidad.

OBJECTIVE: To describe the preliminary results from evaluating the application of an exhaustive geriatric evaluation procedure within primary care. DESIGN: A descriptive crossover study of a non-random sample. SETTING: This was carried out in primary care at an out-station clinic serving a suburban population. PATIENTS AND OTHER PARTICIPANTS: Those people aged 70 and over who requested health-care at the clinic. All the 131 people who attended between February and December 1992 were included in the procedure. MEASUREMENTS AND MAIN RESULTS: The Exhaustive Geriatric Evaluation was applied as an instrument to diagnose hidden health problems. The instrument is composed of functional classification (Katz and Lawton-Brody scales), detection of risk factors which might lead to institutionalisation and an exhaustive clinical assessment (biomedical, psychological and socio-family). The diagnostic usefulness of the procedure is 2.4 +/- 0.21 new diagnoses per patient, for 98% of those to whom the complete new procedure was applied (62.6% of the patients included). Problems of hypoacusis (33.3%), senile memory lapses (41.6%) and urinary incontinence (26.2%) were found to a significant degree (p < 0.05) compared with the previously diagnosed morbidity. On the Katz and Lawton-Brody scales, 74% and 41.9% of patients, respectively, were independent. 55.7% of patients presented at least one risk factor leading to institutionalisation, with loneliness being the most common (35.8% of cases). CONCLUSIONS: The exhaustive geriatric evaluation is valid in primary care in looking after the elderly population, as it leads to the detection of functional and hidden bio-psychosocial problems.