ABSTRACT
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Subject(s)
Humans , Male , Middle Aged , Opsoclonus-Myoclonus Syndrome/pathology , Opsoclonus-Myoclonus Syndrome/therapy , Opsoclonus-Myoclonus Syndrome , Immunosuppressive Agents/therapeutic use , Combined Modality Therapy/methods , Opsoclonus-Myoclonus Syndrome/etiology , Positron-Emission Tomography/methods , Fluorodeoxyglucose F18/administration & dosage , Fluorodeoxyglucose F18/radiation effects , Immunohistochemistry , Pleura/cytologyABSTRACT
The objective of this study was to determine the prevalence of antibodies against alpha-fodrin (alpha-fodrin) of the immunoglobulin G (IgG) isotype in Sjögren's syndrome (SS), as defined by European Community Study Group (ESG) and ESG-modified criteria. We arrived at the prevalence and mean concentrations of IgG anti-alpha-fodrin antibodies using enzyme-linked immunosorbent assay (ELISA) in 507 patients with SS, primary SS (pSS), and secondary SS (sSS), classified according to either the ESG or the ESG-modified criteria. IgG anti-alpha-fodrin antibodies were detected in 6/507 (1.2%) and 4/228 (1.7%) of the SS group, according to the ESG or ESG-modified criteria, respectively. Similar prevalence was found for patients with pSS or sSS. Anti-Ro/SSA antibodies were present in 151/409 (36.9%) vs. 149/213 (70.0%) of the SS group, 85/195 (43.6%) vs. 83/101 (82.2%) of the pSS group, and 66/214 (30.8%) vs. 66/112 (58.9%) of the sSS group. Anti-La/SSB antibodies were detected in 77/403 (19.1%) vs. 73/212 (34.4%) of the SS group, 47/194 (24.2%) vs. 45/101 (44.5%) of the pSS group, and 30/209 (14.3%) vs. 28/111 (25.2%) of the sSS group. No clinical associations were found. Only two IgG anti-alpha-fodrin-positive sera were anti-Ro/SSA-negative. We conclude that IgG antibodies against alpha-fodrin are present in a small percentage of people with SS, pSS, and sSS. The lower prevalence in patients classified according to the ESG criteria reflects the lower specificity of these criteria. IgG anti-alpha-fodrin antibodies can be detected in some SS patients whose sera do not contain anti-Ro/SSA antibodies.
Subject(s)
Antibodies, Anti-Idiotypic/immunology , Carrier Proteins/analysis , Immunoglobulin G/analysis , Microfilament Proteins/analysis , Prevalence , Sjogren's Syndrome/epidemiology , Sjogren's Syndrome/immunology , Antibodies, Antinuclear/analysis , Enzyme-Linked Immunosorbent Assay , Humans , Sjogren's Syndrome/classification , Sjogren's Syndrome/physiopathology , Spain/epidemiologySubject(s)
HIV Infections/complications , Hypertension, Pulmonary/complications , Adult , Female , HumansABSTRACT
The cytopathologic features of the fine needle aspiration cytology of the local recurrence of a vulvar epithelioid sarcoma were documented. The cytologic findings included round polygonal cells with abundant eosinophilic cytoplasm and an eccentrically located nucleus. Despite their epithelioid aspect, the cells in the smears had a sarcomatous arrangement, consisting of isolated cells and loosely cohesive groups. The cytologic findings correlated well with the histologic features of the tumor, which consisted of nodules of eosinophilic epithelioid cells. We discuss the clinical characteristics and prognostic factors in this unusual, vulvar location of this soft tissue sarcoma.
Subject(s)
Neoplasm Recurrence, Local/pathology , Sarcoma/pathology , Vulvar Neoplasms/pathology , Biopsy, Needle , Fatal Outcome , Female , Humans , Middle Aged , Neoplasm Recurrence, Local/diagnosis , Sarcoma/diagnosis , Vulvar Neoplasms/diagnosisABSTRACT
A case of neurilemoma of the left breast in an 83-year-old man is presented, including the fine needle aspiration and biopsy diagnosis. A review of the literature did not reveal the existence of such a tumor in a man's breast. The aspirate yielded a cellular smear composed of clusters of spindle-shaped cells showing minimal atypia and Verocay bodies. The final diagnosis was established on the excised mass through histopathologic study.
Subject(s)
Breast Neoplasms/pathology , Neurilemmoma/pathology , Aged , Aged, 80 and over , Biopsy, Needle , Humans , MaleABSTRACT
The penetration of a gastric peptic ulcer into the liver was initially diagnosed by the cytologic examination of endoscopic brushings and later confirmed by an endoscopic biopsy of the stomach. One of the smears of the gastric brushing contained sparse groups of liver cells with mild atypia. The endoscopic biopsy specimen included liver parenchyma with signs of peptic hepatitis. The differential diagnostic considerations for a gastric brushing containing hepatoid cells are discussed.
Subject(s)
Liver/pathology , Peptic Ulcer Hemorrhage/pathology , Stomach Ulcer/pathology , Aged , Aged, 80 and over , Female , Humans , Stomach Ulcer/complicationsABSTRACT
Clinicoradiologic and pathologic data of a patient with a paraganglioma of the cauda equina are described. The peculiar aspect of this rare case is the gangliocyte differentiation with mature ganglion cells scattered in the tumor. The histologic and ultrastructural features are similar to other described cases of this tumor, with Zellballen pattern and neurosecretory granules. The immunohistochemical studies are quite typical with positive staining with neuroendocrine markers (N.S.E., G.F.A.P.). An interpretation of these findings is made.
Subject(s)
Cauda Equina/pathology , Cell Transformation, Neoplastic/pathology , Neurons/pathology , Paraganglioma/pathology , Peripheral Nervous System Neoplasms/pathology , Adult , Cauda Equina/cytology , Humans , MaleABSTRACT
The malignant schwannoma is a sarcoma which very rarely occurs on the face. This article describes the case of a woman with such a tumour and whose study and evolution shows that was no relation with the nervous trunk, neurofibroma or neurofibromatosis.