ABSTRACT
AIM: Some literatures revealed that the high performance liquid chromatography (HPLC) method for single component or multicomponent analysis of montelukast sodium with other drugs. However, these methods deals with time consuming, so it is necessary to develop a cost-effective and less time consuming method for the estimation of doxofylline and montelukast sodium in combined pharmaceutical formulation. MATERIALS AND METHODS: The separation was performed on an inertsil C8 (5 µm, 4.6 × 250 mm) column in isocratic mode with the mobile phase consisting a mixture of methanol and sodium phosphate buffer (75:25 v/v, pH 6.5 adjusted with orthophosphoric acid). The mobile phase was pumped at a flow rate of 1 mL min(-1) and eluents were monitored at 230 nm. RESULTS: The selected chromatographic conditions were found to separate doxofylline (retention time = 3.4 min) and montelukast sodium (retention time = 5.5 min) with a resolution of 5.47. The proposed HPLC method was validated with respect to linearity, accuracy, repeatability, specificity, robustness, and ruggedness as per International Conference on Harmonisation guidelines Q2(R1), November 2005 (Validation of Analytical Procedures: Text and Methodology). The percentage recoveries for doxofylline and montelukast sodium ranged from 98.1% to 101.7% and 98.2 to 101.9%, respectively, which indicated that the above method was enough accurate and precise. CONCLUSIONS: Hence, it was concluded that the developed method is suitable for routine analysis of these combination due to its less analysis time.
ABSTRACT
Seeking a solution to bring down the prevalence of simple plantar ulcers in the field, Damien Foundation India Trust (DFIT), Chennai, developed a curriculum to teach the field staff of all its projects. The purpose was to make patients self-reliant in the care of their plantar ulcers in their homes. The strategy used was to make patients take care of their ulcers using tools found in their homes and surroundings and become responsible for the care of their limbs. This strategy was implemented in eight projects of DFIT and the programme was followed regularly for one year. Regular monitoring and evaluation showed that under this strategy the prevalence of plantar ulcers was reduced by about 50%.
Subject(s)
Attitude to Health , Foot Ulcer/therapy , Leprosy/psychology , Patient Education as Topic/methods , Self Care/methods , Allied Health Personnel/education , Curriculum , Female , Foot Ulcer/epidemiology , Humans , India/epidemiology , Male , Occupations/classification , PrevalenceABSTRACT
The effect of self-care learning by leprosy patients in prevention of disabilities was studied by adapting two strategies in two subcentres of a project in South India, one through patient education by trained field staff and the other through community education involving trained animators and health committees. One of the subcentres was taken as control where neither of the strategies was employed. In terms of results, though both the strategies were found to be effective in containing occurrence of new deformities among high risk patients and healing of trophic ulcers in hands and feet, strategy I i.e. self-care education of patients by concerned field personnel without prejudice to their routine work is recommended because of ease in diffusion of strategy.
