ABSTRACT
The strive for proficient cosmetic facial appearance is growing in the past decades. Fillers for tissue augmentation are gaining wide popularity. Uncertified products based on oleic solutions are applied by untrained staff, thus growing the risk for certain complications such as infections, allergic and irritant contact dermatitis, and lipogranuloma formation. We present a series of three cases lipogranuloma after liquid vitamin E injection for lip augmentation. In all cases, painful edema at the injected area followed the procedure. The patients were presented with erythema, firm indurations of the lips and the perioral skin, and tenderness. Histological examination of skin biopsies showed round-ovoid cavities of varying sizes, resulting in a Swiss cheese-like appearance, consistent with a lipogranuloma. In this paper, we propose a protocol for treatment of this specific complication with systemic corticosteroids and a broad spectrum antibiotics.
Subject(s)
Cosmetic Techniques/adverse effects , Dermal Fillers/adverse effects , Granuloma, Foreign-Body/chemically induced , Lip Diseases/chemically induced , Rejuvenation , Vitamin E/adverse effects , Adolescent , Adrenal Cortex Hormones/therapeutic use , Adult , Anti-Bacterial Agents/therapeutic use , Biopsy , Dermal Fillers/administration & dosage , Drug Therapy, Combination , Female , Granuloma, Foreign-Body/diagnosis , Granuloma, Foreign-Body/drug therapy , Humans , Injections, Subcutaneous , Lip Diseases/diagnosis , Lip Diseases/drug therapy , Treatment Outcome , Vitamin E/administration & dosage , Young AdultABSTRACT
Among the numerous idiopathic immune-mediated diseases that can be drug-induced, such as pemphigus, psoriasis, lichen, etc, drug-induced lupus is the most widely commented upon and investigated. The terms drug-induced lupus (DIL) and drug-induced lupus erythematosus (DILE) are preferred, but other ones are also used--drug-related lupus, lupus-like syndrome, and lupus erythematosus medicamentosus. This review discusses the general issues in DILE, such as pathogenic mechanisms, clinical forms, and diagnostic criteria, and provides more detailed information for some of the implicated drugs: minocycline, statins, terbinafine, etc.
