Extended Methodology for DFA and DCCA: Application of Automatic Search Procedure and Correlation Map to the Weierstrass-Mandelbrot Functions.

Detrended fluctuation analysis and detrended cross-correlation analysis are used in this study to identify and characterize correlated data. The objective of these two techniques is to separate different fluctuations from the contributions due to external trends by evaluating the autocorrelation and cross-correlation exponents, in order to determine if scale properties persist with the size of the series. Two new methodologies were extended from cross-correlation coefficients for local analysis, which we call the \textit{automatic search procedure.

Intrathecal IgM-synthesis does not correlate with the risk of relapse in patients with a primary demyelinating event.

The objective of this study was to investigate, whether the presence of oligoclonal immunoglobulin M bands (IgM-OCB) in cerebrospinal fluid (CSF) from patients with a clinically isolated syndrome (CIS), which is suggestive for the first clinical manifestation of multiple sclerosis (MS), anticipates the risk of a relapse during a retrospective study period of 21-106 months (mean 60 +/- 25). A relapse would lead to the diagnosis of clinically definite MS. Paired CSF and serum samples from 42 patients with a CIS and positive intrathecal IgG-synthesis were tested retrospectively for IgM-OCB, which are exclusively present in CSF, but not in the corresponding serum. Isoelectric focusing and affinity blot were used and clinical follow-up was based on telephone interviews. IgM-OCB were found in the CSF from 31 of 42 patients (74%). There was no correlation between the presence of IgM-OCB, the number of such bands or the IgM-Index on the one hand and the risk of a relapse during the follow-up in the cohort studied, on the other hand. These data do not support the idea that the presence of IgM-OCB in CSF might predict an unfavourable course in MS.

Antimyelin antibodies and the risk of relapse in patients with a primary demyelinating event.

AIM: To investigate whether the presence of serum antibodies against myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP) in patients with a clinically isolated syndrome (CIS) predicts the interval to develop more frequently and earlier a first relapse (clinically definite multiple sclerosis: CDMS) than seronegative patients. METHODS: Sera from 45 patients with a CIS and positive intrathecal IgG-synthesis were retrospectively tested for the presence of IgM antibodies against both MOG and MBP. Antibodies were detected by immunoblot using recombinant MOG (1-125) and human MBP antigen preparations. Clinical follow ups were performed retrospectively by telephone interviews and documented neurological examination. RESULTS: Using the Cox proportional hazards model there was no significant increased risk for developing CDMS in anti-MOG and anti-MBP positive patients compared with negative. However regarding the median of the time span between CIS and CDMS over the whole follow up, antibody positive patients (MOG/MBP +/+) developed significantly earlier relapses (median 5.5 months (range 3-20)) than the antibody negative ones (median 25.0 months (range 7-43); p<0.006). On testing sera from 56 apparently healthy students, quite high frequencies of anti-MOG and anti-MBP antibodies (21% and 28% respectively) were detected. This limited specificity of anti-MOG and anti-MBP antibodies has been seen earlier and restricts their diagnostic relevance in MS despite their role as a predictor of relapses after a CIS. CONCLUSIONS: This study confirms previous data only in a subanalysis indicating that patients with positive anti-MOG/MBP antibodies develop earlier relapses than patients who are antibody negative. However, the authors could not verify that the presence of these antibodies anticipates the overall risk of developing CDMS-according to study criteria-after a first demyelinating event within the study period of 21-106 months (mean 60 (SD 25)).

Proposal for modification of the TNM staging classification for cancer of the oral cavity. DOSAK.

AIM: The prognostic value of the TNM and pTNM classifications currently used for tumours of the oral cavity is unsatisfactory. A better classification should be aimed at as today's definition of T4 leads to overclassification of many tumours and today's definition of N3 results in too few lymph nodes in this group. Until 1987 the grade of fixation of lymph-nodes was part of the N-classification for oral cancer as it is currently used in the N-classification of breast cancer. METHODS: From 1987 to 1991 the DOSAK tumour registry has stored 1532 primary cases of cancer of the oral cavity from 23 hospitals. Crosstables were applied to outline the classification rule for clinical and histopathological T and N based on important factors (T: tumour diameter and thickness; N: lymph node diameter and grade of fixation; pT: histopathological tumour diameter and thickness; pN: number of lymph nodes involved by the tumour). A Cox model was calculated and combinations of similar prognostic estimates were summarized to the same clinical and histopathological T and N. It was aimed at separating categories and achieving equivalent clinical and histopathological T classifications and group frequencies. In a final step a clinical and histopathological stage grouping can be proposed. RESULTS: The gradation of the survival rates shows a marked separation between the T, N and stage categories. The distribution of T, N and stage categories was more uniform when applying the new classification.

A flaw in gerontological assessment: the weak relationship of elderly superficial life satisfaction to deep psychological well-being.

This study assessed the degree of relationship between superficial and deep psychological adjustment among elderly individuals. Eighty-six middle-class, Anglo persons averaging seventy-six years of age participated. Roughly one-half of the sample were "independent living," with the other half "congregate apartment dwelling." A similarly equal representation of both sexes was achieved. Superficial psychological well-being was measured using Cantril's Self-Anchoring Scale for life satisfaction, while deep psychological well-being was measured using portions of the Eriksonian-based Measures of Psychosocial Development. It was hypothesized that no more than a moderate correlation (.50) would be found to exist between shallow and deep psychological adjustment. This hypothesis was confirmed, suggesting that gerontologists need to cease relying on superficial psychological measures for elderly assessment, and implement more depth-oriented tests. It is argued that failure to do this promulgates an unfortunate tradition of shallow, inaccurate psychological measurement within gerontology.